Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Highly sensitive dopamine detector uses 2D materials

Schematic of a highly selective dopamine detector using two-dimensional material.

CREDIT
Derrick Butler, Penn State
Schematic of a highly selective dopamine detector using two-dimensional material. CREDIT Derrick Butler, Penn State

Abstract:
A supersensitive dopamine detector can help in the early diagnosis of several disorders that result in too much or too little dopamine, according to a group led by Penn State and including Rensselaer Polytechnic Institute and universities in China and Japan.

Highly sensitive dopamine detector uses 2D materials

University Park, PA | Posted on August 7th, 2020

Dopamine is an important neurotransmitter that can be used to diagnose disorders such as Parkinson's disease, Alzheimer's disease and schizophrenia.

"If you can develop a very sensitive, yet simple-to-use and portable, detector that can identify a wide range of dopamine concentration, for instance in sweat, that could help in non-invasive monitoring of an individual's health," said Aida Ebrahimi, assistant professor of electrical engineering, Penn State, and a corresponding author on a paper published Aug. 7 in Science Advances.

Their work shows that by adding a small amount of manganese to a two-dimensional layered material called molybdenum disulfide, they can improve the sensitivity by many orders of magnitude compared to other reported results, while also achieving high specificity. Importantly, their detector is low-cost and flexible, and can detect dopamine in background media including buffer, serum and sweat, and in real-time.

"Regarding our method, electrochemical deposition is a new way of depositing these chemicals that is very simple and scalable," said Mauricio Terrones, Verne M. Willaman Professor of Physics, Materials Science and Chemistry and the second corresponding author. "The air force is interested in these neurotransmitters that are makers of stress. I envision this as a wearable sensor."

Humberto Terrones and his group, at RPI, performed the computational investigation that allowed them to explain how addition of manganese results in an improved response to dopamine. The experimental work was performed within the Center for Atomically Thin Multifunctional Coatings (ATOMIC) at Penn State.

"Combining the experimental results with computational studies proved to be very insightful, and I think we all learned much more throughout this project because of that," said Derrick Butler, a co-lead author on the paper and doctoral student at Penn State. "Developing these materials and applying them in a way that could improve the health and well-being of others makes the work especially enjoyable and rewarding."

His co-lead author, doctoral candidate Yu Lei, added, "One challenge is to develop a scalable method to bridge fundamental studies and practical applications. Our method is based on electrodeposition, which has been widely used in industry, thus providing a scalable route to functionalize MoS2 in a scalable way. Also, I believe this multidisciplinary team is the key to find the right way to functionalize MoS2 for ultrasensitive dopamine detection."

In further work, the group hopes to find other material combinations to detect a variety of other biomarkers with the specificity of their current sensor. Creating such a "toolkit" combining experimental investigations with computational methods will lead to new materials with multifunctional capabilities. This might be useful beyond human health, for example, for detecting noxious gases, water contamination or biodefense agents.

"In future, we can envision a combined sensor/actuator that can detect the dopamine and provide therapy at the same time. The sensors can be integrated with miniaturized chips for integration of sensing, actuating, control and data processing," Ebrahimi said.

###

In addition to Ebrahimi, Lei, Butler and the Terrones brothers, authors include Fu Zhang and Tomotaroh Granzier-Nakajiwa, former or current doctoral students at Penn State, and Kazinora Fujisawa, currently a post-doctoral scholar, Penn State. Their paper is titled "Single-Atom Doping of MoS2 with Manganese Enables Ultrasensitive Detection of Dopamine: Experimental and Computational Approach."

National Science Foundation, IUCRC-ATOMIC Center and Ebrahimi's Start-up fund provided support for this project.

####

For more information, please click here

Contacts:
A'ndrea Elyse Messer

814-865-5689

@penn_state

Terrones can be contacted at
Ebrahimi can be contacted at

Copyright © Penn State

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

The National Space Society Congratulates Blue Origin and Jeff Bezos for the Spectacular First Crewed Flight of the New Shepard: Well-Tested Suborbital Tourist Rocket Soars to 63 Miles; Opens New Frontiers July 21st, 2021

Unconventional superconductor acts the part of a promising quantum computing platform: If it looks like a duck, swims like a duck and quacks like a duck, then it probably is a duck. July 16th, 2021

Unlocking efficient light-energy conversion with stable coordination nanosheets: Scientists design a high-performance, self-powered, UV photodetector using 2D nanosheets that show record photocurrent stability under air exposure July 16th, 2021

The virus trap: Hollow nano-objects made of DNA could trap viruses and render them harmless July 16th, 2021

2 Dimensional Materials

Putting functional proteins in their place: Using DNA-based assembly, scientists developed a method for creating designed and biologically active 2-D and 3-D protein arrays, which show promise for applications in structural biology, biomaterials, nanomedicine, and biocatalysis June 25th, 2021

Atomic-scale tailoring of graphene approaches macroscopic world June 18th, 2021

Changing a 2D material's symmetry can unlock its promise: Jian Shi Research Group engineers material into promising optoelectronic June 18th, 2021

Rice lab peers inside 2D crystal synthesis: Simulations could help molecular engineers enhance creation of semiconducting nanomaterials June 11th, 2021

Hexagonal boron nitride's remarkable toughness unmasked: 2D material resists cracking and description by century-old theory of fracture mechanics June 2nd, 2021

Wearable electronics

A molecule like a nanobattery: Chemical scientists decipher complex electronic structure of a three-nuclear metallorganic compound with the capacity of donating and receiving multiple electrons June 9th, 2021

New brain-like computing device simulates human learning: Researchers conditioned device to learn by association, like Pavlov's dog April 30th, 2021

CEA-Leti Announces EU Project to Mimic Multi-Timescale Processing of Biological Neural Systems: Targeted Applications Include High-Dimensional Distributed Environmental Monitoring, Implantable Medical-Diagnostic Microchips, Wearable Electronics & Human/Computer Interfaces April 23rd, 2021

Govt.-Legislation/Regulation/Funding/Policy

The virus trap: Hollow nano-objects made of DNA could trap viruses and render them harmless July 16th, 2021

Scientists create rechargeable swimming microrobots using oil and water July 16th, 2021

Scientists take first snapshots of ultrafast switching in a quantum electronic device: They discover a short-lived state that could lead to faster and more energy-efficient computing devices July 16th, 2021

Stress-free path to stress-free metallic films paves the way for next-gen circuitry: Optimized sputtering technique helps minimize stress in tungsten thin films July 4th, 2021

Possible Futures

The National Space Society Congratulates Blue Origin and Jeff Bezos for the Spectacular First Crewed Flight of the New Shepard: Well-Tested Suborbital Tourist Rocket Soars to 63 Miles; Opens New Frontiers July 21st, 2021

Scientists create rechargeable swimming microrobots using oil and water July 16th, 2021

Scientists take first snapshots of ultrafast switching in a quantum electronic device: They discover a short-lived state that could lead to faster and more energy-efficient computing devices July 16th, 2021

Researchers discover a new inorganic material with lowest thermal conductivity ever reported July 16th, 2021

Sensors

Unlocking efficient light-energy conversion with stable coordination nanosheets: Scientists design a high-performance, self-powered, UV photodetector using 2D nanosheets that show record photocurrent stability under air exposure July 16th, 2021

Repairs using light signals: FAU research group develops smart microparticle that identifies defective parts in electrical appliances July 16th, 2021

A molecule like a nanobattery: Chemical scientists decipher complex electronic structure of a three-nuclear metallorganic compound with the capacity of donating and receiving multiple electrons June 9th, 2021

Using the environment to control quantum devices: A deeper understanding of how the environment impacts quantum behaviour is bringing quantum devices one step closer to widespread adoption June 1st, 2021

Discoveries

Repairs using light signals: FAU research group develops smart microparticle that identifies defective parts in electrical appliances July 16th, 2021

Removing the lead hazard from perovskite solar cells July 16th, 2021

Scientists create rechargeable swimming microrobots using oil and water July 16th, 2021

Scientists take first snapshots of ultrafast switching in a quantum electronic device: They discover a short-lived state that could lead to faster and more energy-efficient computing devices July 16th, 2021

Announcements

The National Space Society Congratulates Blue Origin and Jeff Bezos for the Spectacular First Crewed Flight of the New Shepard: Well-Tested Suborbital Tourist Rocket Soars to 63 Miles; Opens New Frontiers July 21st, 2021

Scientists create rechargeable swimming microrobots using oil and water July 16th, 2021

Scientists take first snapshots of ultrafast switching in a quantum electronic device: They discover a short-lived state that could lead to faster and more energy-efficient computing devices July 16th, 2021

Researchers discover a new inorganic material with lowest thermal conductivity ever reported July 16th, 2021

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

RUDN University chemists obtained an unusual planar nickel complex exhibiting magnetic properties July 16th, 2021

Repairs using light signals: FAU research group develops smart microparticle that identifies defective parts in electrical appliances July 16th, 2021

Scientists create rechargeable swimming microrobots using oil and water July 16th, 2021

Scientists take first snapshots of ultrafast switching in a quantum electronic device: They discover a short-lived state that could lead to faster and more energy-efficient computing devices July 16th, 2021

Homeland Security

Sensors developed at URI can identify threats at the molecular level: More sensitive than a dog's nose and the sensors don't get tired May 21st, 2021

UCF researchers generate attosecond light from industrial laser: The ultrafast measurement of the motion of electrons inside atoms, molecules and solids at their natural time scale is known as attosecond science and could have important implications in power generation, chemical- August 25th, 2020

RIT researchers build micro-device to detect bacteria, viruses: New process improves lab-on-chip devices to isolate drug-resistant strains of bacterial infection, viruses April 17th, 2020

Nanomaterial fabric destroys nerve agents in battlefield-relevant conditions: Metal-organic framework-based composites don’t need liquid water to work January 14th, 2020

Military

‘Flashed’ nanodiamonds are just a phase: Rice produces fluorinated nanodiamond, graphene, concentric carbon via flash Joule heating June 23rd, 2021

Novel liquid crystal metalens offers electric zoom June 17th, 2021

Magnetism drives metals to insulators in new experiment: Study provides new tools to probe novel spintronic devices June 4th, 2021

Implantable 'living pharmacy' could control body's sleep/wake cycles: Project receives DARPA contract worth up to $33 million over 4 1/2 years May 13th, 2021

Environment

Light-harvesting nanoparticle catalysts show promise in quest for renewable carbon-based fuels June 25th, 2021

Active platinum species: Catalytic high-temperature oxidations: Individual atom or metal cluster? June 16th, 2021

Wearable sensors that detect gas leaks April 19th, 2021

TPU scientists offer new plasmon energy-based method to remove CO2 from atmosphere March 19th, 2021

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

The National Space Society Congratulates Blue Origin and Jeff Bezos for the Spectacular First Crewed Flight of the New Shepard: Well-Tested Suborbital Tourist Rocket Soars to 63 Miles; Opens New Frontiers July 21st, 2021

The virus trap: Hollow nano-objects made of DNA could trap viruses and render them harmless July 16th, 2021

Removing the lead hazard from perovskite solar cells July 16th, 2021

Scientists create rechargeable swimming microrobots using oil and water July 16th, 2021

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project