Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > PRINTed Nanoparticles Delivery Multiple Punches to Treat Prostate Cancer

Abstract:
Using technologies common to the semiconductor industry, a team of investigators at the University of North Carolina at Chapel Hill and Liquidia Technologies has created a polymer nanoparticle that can encapsulate large loads of therapeutic molecules that may have use in treating prostate cancer. The research, led by Joseph DeSimone, co-principal investigator of the Carolina Center for Cancer Nanotechnology, was published in the journal Nano Letters.

PRINTed Nanoparticles Delivery Multiple Punches to Treat Prostate Cancer

Bethesda, MD | Posted on January 19th, 2012

Dr. DeSimone and his colleagues developed their nanoparticles to deliver small interfering RNA (siRNA) molecules to tumors. siRNAs block or greatly reduce a cell's production of specific proteins by binding to the messenger RNA (mRNA) molecules that translate information from DNA into proteins. Because of their specificity for specific proteins, siRNAs are thought to hold promise as anticancer agents, but only if techniques can be developed to deliver large quantities of siRNAs to tumor cells.

With an eye on commercialization, the Carolina team created an siRNA delivery vehicle using the PRINT process, which was invented in Dr. DeSimone's laboratory and is now being developed for biomedical applications by Liquidia Technologies. PRINT uses soft lithography to mass produce polymeric nanoparticles under mild conditions suitable for use with biologically compatible materials. In this project, the team created nanoparticles consisting of a polymer core that safely encapsulates siRNA molecules and a lipid shell that promotes cell uptake.

Initial tests with cells engineered to produce a fluorescent protein and a nanoparticle containing an siRNA agent that would block production of this protein, the investigators showed that these particles were readily taken up by the cells. Once inside the cells, the polymeric nanoparticles released their siRNA payload, blocking production of the fluorescent protein.

Next, the investigators created a nanoparticle containing an siRNA designed to interfere with the production of a protein known as KIF11, which plays a role in prostate tumor growth. They then dosed three different prostate cancer cell lines with this formulation and found that all three cell lines experienced a dramatic drop in KIF11 levels, which in turn triggered cell death in all three cell lines. The researchers note that they are now performing animal studies with PRINTed nanoparticles loaded with siRNAs targeted to key tumor proteins.

####

About The National Cancer Institute (NCI)
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © The National Cancer Institute (NCI)

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - "Delivery of multiple siRNAs using lipid-coated PLGA nanoparticles for treatment of prostate cancer."

Related News Press

News and information

Hanging by a thread: Imaging and probing chains of single atoms: Scientists develop a method to visualize monoatomic chains and measure the strength and conductance of single-atom bonds May 14th, 2021

Nanophotonics enhanced coverslip for phase imaging in biology May 14th, 2021

New technology enables rapid sequencing of entire genomes of plant pathogens May 14th, 2021

Harvesting light like nature does:Synthesizing a new class of bio-inspired, light-capturing nanomaterials May 14th, 2021

Govt.-Legislation/Regulation/Funding/Policy

Hanging by a thread: Imaging and probing chains of single atoms: Scientists develop a method to visualize monoatomic chains and measure the strength and conductance of single-atom bonds May 14th, 2021

Nanophotonics enhanced coverslip for phase imaging in biology May 14th, 2021

New technology enables rapid sequencing of entire genomes of plant pathogens May 14th, 2021

Harvesting light like nature does:Synthesizing a new class of bio-inspired, light-capturing nanomaterials May 14th, 2021

Nanomedicine

Implantable 'living pharmacy' could control body's sleep/wake cycles: Project receives DARPA contract worth up to $33 million over 4 1/2 years May 13th, 2021

Tiny, Wireless, Injectable Chips Use Ultrasound to Monitor Body Processes May 12th, 2021

World's first fiber-optic ultrasonic imaging probe for future nanoscale disease diagnostics April 30th, 2021

Arrowhead Announces Improvement in Fibrosis after ARO-AAT Treatment in Patients with Alpha-1 Liver Disease April 28th, 2021

Discoveries

Emergence of a new heteronanostructure library May 14th, 2021

Hanging by a thread: Imaging and probing chains of single atoms: Scientists develop a method to visualize monoatomic chains and measure the strength and conductance of single-atom bonds May 14th, 2021

Nanophotonics enhanced coverslip for phase imaging in biology May 14th, 2021

You're so vein: Scientists discover faster way to manufacture vascular materials May 14th, 2021

Announcements

Emergence of a new heteronanostructure library May 14th, 2021

Nanophotonics enhanced coverslip for phase imaging in biology May 14th, 2021

New technology enables rapid sequencing of entire genomes of plant pathogens May 14th, 2021

Harvesting light like nature does:Synthesizing a new class of bio-inspired, light-capturing nanomaterials May 14th, 2021

Printing/Lithography/Inkjet/Inks/Bio-printing/Dyes

With a zap of light, system switches objects' colors and patterns: "Programmable matter" technique could enable product designers to churn out prototypes with ease May 6th, 2021

New 3D-Bioprinter + Bioink Use Living Cells Straight From Culture Plate: Cell models mimicking natural tissue topography herald new era for biomedical research April 13th, 2021

Weak force has strong impact on nanosheets: Rice lab finds van der Waals force can deform nanoscale silver for optics, catalytic use December 15th, 2020

Materials scientists learn how to make liquid crystal shape-shift September 25th, 2020

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project