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Abstract:
Market Outlook for Applications, Tools and Materials, and 40 Company Profiles

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Nanotechnology in Healthcare

Posted on July 7th, 2010

The advent of healthcare nanotechnology has had a vast impact in the fields of drug delivery and diagnostics. The role of nanotechnology in healthcare is very important in terms of eradicating diseases, especially in terms of treating cancer. Advanced technological developments in coatings and implants using nanotechnology is expected to increase the scope of the market in various applications.

This report covers different regional application markets, while evaluating them over the next five years. It provides information about the largest regional markets and factors influencing them, while defining the opportunities they present.

Key features of this report

• •Provides an analysis of market data (revenues) of healthcare nanotechnology applications in North America, Europe, Asia and Rest of World that includes Middle East, Africa, Russia, Latin America and Australia.

• Studies key market drivers and restraints for the main market and evaluation of respective sub segments with respect to market dynamics.

• Discusses drug delivery and formulations, biocompatible implants, regenerative medicine and wound care and diagnostics under the applications market along with related sub segments.

Scope of this report

• Understanding the existing and emerging applications of healthcare nanotechnology and their relative and forecast market sizes

• Understanding the product/technological developments on which the companies are focusing for their growth.

• Understanding the different nanotechnology based tools and their importance in the development of new products and applications

Key Market Issues

• Nanotechnology initiatives by developing countries are helping in the development of new products and applications.

• The delay in commercialization due to strict regulations and manufacturing difficulties is inhibiting product reach.

• Stability of nanoparticles inside the biological tissues is an important issue to be considered to reduce contamination by drugs.

• The development of biodegradable nanostructures will be a growth driver in future since they eliminate the issue of excretion.

Key findings from this report

• The healthcare nanotechnology market growth is largest in North America, at $4.75bn in 2009, followed by Europe at $3.65.

• The nanotechnology drug delivery market is expected to grow at a CAGR of 21.7% for the period 2009-14, to reach almost $16bn by 2014.

• Biocompatible implants and coatings and diagnostics comprise some of the major applications which are estimated to experience high growth between 2009 and 2014, 42% and 21.8% respectively.

Key questions answered

• What are the important healthcare nanotechnology markets and their growth over the period 2009-14?

• What are the major applications that have emerged in different areas such as drug formulations and delivery, biocompatible implants and coatings, regenerative medicines and wound care and diagnostics?

• In which areas are the companies focusing while forming strategic alliances with other industry players?

Companies mentioned

Abraxis BioSciences, AstraZeneca, Capsulution Nanoscience AG, Do-Coop, Elan Corporation, J.R. Nanotech, Liquidia Technologies, Merck KGaA, Novartis, Pioneer Surgical, Smith & Nephew, Star Pharma and Wyeth Pharmaceutical

Table of Contents

Nanotechnology in Healthcare

Executive summary 16

Market overview 16

Healthcare nanotechnology market dynamics 16

Nanomaterials & nanotools for the healthcare market 17

Healthcare nanotechnology application market 18

Company profiles 19

Chapter 1 Market overview 22

Summary 22

Introduction 23

Market definition 23

Healthcare nanotechnology business processes 24

Healthcare nanotechnology applications 24

Healthcare nanotechnology application prospects 25

Opportunity matrix 26

Challenge matrix 28

Patent analysis 29

Chapter 2 Healthcare nanotechnology market dynamics 34

Summary 34

Introduction 35

Regional markets 36

North America 37

Europe 38

Asia 38

Competitive landscape 39

R&D activities by applications 41

New product launches 42

Collaborations & agreements 43

Market drivers 56

Nanotechnology research initiatives in developing nations 56

Innovations are increasing 56

Reduced toxicity 56

Market inhibitors 57

Delay in commercialization 57

Stability and other issues 57

Need for particle evaluation 57

Chapter 3 Nanomaterials & nanotools for the healthcare market 60

Summary 60

Introduction 61

Nanomaterials 61

Nanocapsules 61

Drivers 61

Inhibitors 62

Opportunities 62

Nanoporous materials 63

Drivers 63

Opportunities 63

Quantum dots 63

Drivers 64

Inhibitors 64

Opportunities 64

Nanotubes 65

Drivers 65

Nanowires 65

Drivers 66

Inhibitors 66

Opportunities 66

Dendrimers 67

Drivers 67

Opportunities 68

Monoclonal antibodies 68

Drivers 68

Inhibitors 69

Opportunities 69

Nanocomposites 69

Fullerenes 70

Nanofilms 70

Drivers 71

Inhibitors 71

Opportunities 71

Nanotools 72

Nanoarrays 72

Drivers 72

Inhibitors 73

Opportunities 73

Nanobiochip 74

Drivers 74

Opportunities 75

Nanolithography arrays 75

Drivers 75

Inhibitors 76

Opportunities 76

Computer-assisted drug discovery 77

Nanomass spectrometry 77

Drivers 77

Inhibitors 78

Opportunities 78

Congruent Force Intermolecular Test (nanotype) C-FIT 78

Chapter 4 Healthcare nanotechnology application market 82

Summary 82

Introduction 83

Drug formulation and delivery 83

Formulation 84

Drivers 85

Inhibitors 86

Opportunities 86

Fluorescently encoded microparticles 86

Nanoparticulate formulation/systems 88

Fluoropolymers as material platforms for drug therapy 88

DNA nanoparticle technology to produce DNA drugs 89

Drug profiling using smart materials 90

Supercritical fluids and water based nanomaterials 91

Dendrimer nanotechnology products 92

Potential healthcare nanotechnology drug formulation application 93

Drug delivery 93

Drivers 94

Inhibitors 95

Opportunities 95

Nanoencapsulation using nano-device platform 96

Smart materials for encapsulation 97

Antimicrobial nanoencapsulation 98

Nanoscale cochlear drug delivery 99

Drug delivery using nanoparticles 99

Nanocrystals for drug delivery 102

Drug delivery coatings 103

Nanopores 103

Nanocomposites 104

Nanotransponders 105

Potential applications of healthcare nanotechnology drug delivery 105

Biocompatible implants and coatings 106

Drivers 108

Nanofibers fight immune response 108

Improvement in biocompatibility 108

Optimized coatings 108

Improvement in dental implants 108

Inhibitors 108

Improvement of implant depends upon coatings 108

Possibility of mass poisoning 109

Opportunities 109

Improved brain implants 109

Improvement in process for better coatings 109

Helpful in orthopedic devices 109

Surface modification 109

Device coating 110

Drivers 112

Inhibitors 112

Opportunities 112

Sol-gel coatings 113

Biocompatible nanocoatings 113

Nanoscale plasma coating 113

Light-activated antimicrobials 113

Silver nanoparticles 114

Hydrophobic coatings 114

Multifunctional coatings 114

Anti-fouling nanocoatings 114

Passive hydroxyapatite coating 115

Other protective coatings 115

Implants 116

Drivers 116

Opportunities 117

Potential biocompatible implants applications 117

Life support devices using novel biocompatible polymers 117

Stimulation electrodes using nanotechnology 117

Noninvasive killing of cancer cells using localized heat 118

Artificial vascular grafts 118

Bone graft substitutes 118

Regenerative medicine and wound care 118

Regenerative medicine/tissue engineering 119

Drivers 120

Inhibitors 121

Opportunities 121

Potential applications of regenerative medicines 123

Wound care 124

Drivers 124

Opportunities 125

Nanosilver gels 125

Nanogold gels 125

Diagnostics 126

Drivers 127

Improved bioassays 127

Earlier diagnosis and effective monitoring 127

Opportunities 127

Treatment of ovarian cancer 127

Development of immunoassays 128

Quantum dots applications 128

Nanoemulsions in multimodal molecular imaging and targeted therapeutics 128

Nanoparticles for biochemical applications 129

Magnetic nanoparticles for medical diagnostic imaging 129

Encapsulation of radioactive nanoparticle 129

Genome sequencing 129

Nanobiosensors 130

Nanoarray biochips 130

Silicon-based chips/sensors for pH and pressure 130

Micro- and nano-replication for point-of-use analytical applications 131

Nanocells 131

Redox enzymes 131

Other potential diagnostics applications 132

Smart card diagnostics 132

Novel microfluidic technologies 132

Chapter 5 Company profiles 134

Summary 134

Abraxis BioScience, Inc. 135

Company overview 135

Products and services 135

Company strategy 136

Access Pharmaceuticals, Inc. 137

Company overview 137

Products and services 137

Company strategy 138

AstraZeneca 138

Company overview 138

Products and services 139

Company strategy 139

AMAG Pharmaceuticals, Inc. 139

Company overview 139

Products and services 140

Company strategy 140

Aphios Corp. 140

Company overview 141

Products and services 141

Company strategy 142

Asklepios Biopharmaceutical Inc. 142

Company overview 143

Products and services 143

Company strategy 143

Capsulution Nanoscience AG 144

Company overview 144

Products and services 144

Company strategy 144

ConvaTec 145

Company overview 145

Products and services 145

Company strategy 146

Debiotech 146

Company overview 146

Products and services 146

Company strategy 147

Do-Coop Technologies Ltd. 147

Company overview 147

Products and services 147

Company strategy 148

Elan Corp. 148

Company overview 148

Products and services 148

Company strategy 149

Ferro Corp. 149

Company overview 149

Products and services 150

Company strategy 150

Flamel Technologies 150

Company overview 151

Products and services 151

Company strategy 151

GE Global Research 152

Company overview 152

Company strategy 152

GfE Medizintechnik GmbH 153

Company overview 153

Products and services 153

Company strategy 154

HemCon Medical Technologies, Inc. 154

Company overview 154

Company strategy 155

iCeutica Inc 155

Company overview 155

Products and services 156

Company strategy 156

Liquidia Technologies 157

Company overview 157

Company strategy 157

Luna Innovations Inc. 158

Company overview 158

Products and services 158

Company strategy 159

MagForce Nanotechnologies AG 159

Company overview 160

Products and services 160

Company strategy 161

Merck KGaA 161

Company overview 161

Products and services 162

Company strategy 162

MIV Therapeutics Inc 162

Company overview 163

Products and services 163

Company strategy 163

Nanomix 163

Company overview 164

Products and services 164

Company strategy 164

Nano Interface Technology, Inc 165

Company overview 165

Products and services 165

Company strategy 165

NanoCarrier Co., Ltd. 165

Company overview 166

Products and services 166

Company strategy 166

NanoDel Technologies 167

Company overview 167

Products and services 167

Company strategy 167

NanoHorizons Inc. 168

Company overview 168

Products and services 168

Company strategy 168

Nanoprobes, Inc. 169

Company overview 169

Products and services 169

Company strategy 169

Nanospectra Biosciences Inc. 170

Company overview 170

Products and services 170

Company strategy 170

Nanosphere, Inc. 171

Company overview 171

Products and services 171

Company strategy 172

Novartis AG 172

Company overview 173

Products and services 173

Company strategy 173

Pfizer 173

Company overview 173

Company strategy 174

PharmaSol GmbH 174

Company overview 174

Products and services 174

Company strategy 175

Pioneer Surgical Technology 175

Company overview 175

Products and services 175

Company strategy 176

pSivida 176

Company overview 176

Products and services 176

Company strategy 176

F. Hoffmann-La Roche Ltd. 177

Company overview 177

Products and services 177

Company strategy 177

Siemens Medical Solutions 178

Company overview 178

Products and services 179

Company strategy 179

Smith & Nephew 179

Company overview 179

Products and services 180

Company strategy 180

Starpharma Holdings Ltd. 181

Company overview 181

Products and services 181

Company strategy 182

T2 Biosystems Inc. 183

Company overview 183

Company strategy 183

Appendix 184

Patents 184

Glossary 218

List of Figures

Figure 1.1: Global healthcare nanotechnology market 23

Figure 1.2: Geographical patent share, 2003-08 30

Figure 1.3: Number of patents by region, 2003-09 30

Figure 1.4: Comparison of patent trends, 2004 vs 2009 31

Figure 2.5: Developmental strategies by major players, January 2007-November 2009 40

Figure 2.6: R&D activities by applications, Jan 2007-Nov 2009 41

Figure 2.7: New product launches, Jan 2007-Nov 2009 42

Figure 2.8: Collaborations & agreements by applications, Jan 2007-Nov 2009 43

Figure 2.9: Relative importance of features of healthcare nanotechnology 58

List of Tables

Table 2.1: Global healthcare nanotech market, by geography ($m), 2007-14 37

Table 2.2: Mergers & acquisitions in healthcare nanotech market, 2007-09 44

Table 2.3: New product launches in healthcare nanotech market, 2007-09 45

Table 2.4: New product launches in healthcare nanotech market, 2007-09 (ctd) 46

Table 2.5: R&D in healthcare nanotech market, 2007-09 47

Table 2.6: R&D in healthcare nanotech market, 2007-09 (ctd 1) 48

Table 2.7: R&D in healthcare nanotech market, 2007-09 (ctd 2) 49

Table 2.8: R&D in healthcare nanotech market, 2007-09 (ctd 3) 50

Table 2.9: R&D in healthcare nanotech market, 2007-09 (ctd 4) 51

Table 2.10: R&D in healthcare nanotech market, 2007-09 (ctd 5) 52

Table 2.11: R&D in healthcare nanotech market, 2007-09 (ctd 6) 53

Table 2.12: Collaborations & agreements in healthcare nanotech market, 2007-09 54

Table 2.13: Collaborations & agreements in healthcare nanotech market, 2007-09 (ctd) 55

Table 4.14: Global healthcare nanotech drug formulation and delivery market, by product ($m), 2007-14 83

Table 4.15: Global healthcare nanotech drug formulation and delivery market, by geography ($m), 2007-14 84

Table 4.16: Global healthcare nanotechnology drug formulation market, by product ($m), 2007-14 85

Table 4.17: Global healthcare nanotech fluorescently encoded microparticles market, by geography ($m), 2007-14 87

Table 4.18: Global healthcare nanotech nanoparticulate formulation/systems market, by geography ($m), 2007-14 88

Table 4.19: Global healthcare nanotech fluoropolymers material platforms for drug therapy market, by geography ($m), 2007-14 89

Table 4.20: Global healthcare DNA nanoparticle technology to produce DNA drugs market, by geography ($m), 2007-14 90

Table 4.21: Global healthcare nanotech drug profiling using smart materials market, by geography ($m), 2007-14 91

Table 4.22: Global healthcare nanotech supercritical fluids and water based nanomaterials market, by geography ($m), 2007-14 91

Table 4.23: Global dendrimer nanotech products market by geography ($m), 2007-14 92

Table 4.24: Global healthcare nanotech drug delivery market by product ($m), 2007-14 94

Table 4.25: Global healthcare nanoencapsulation using nano-device platform market, by product ($m), 2007-14 96

Table 4.26: Global healthcare nanoencapsulation using nano-device platform market, by geography ($m), 2007-14 97

Table 4.27: Global market for smart materials encapsulating pharmaceuticals, by geography ($m), 2007-14 98

Table 4.28: Global healthcare nanotech antimicrobial nanoencapsulation, by geography ($m), 2007-14 98

Table 4.29: Global healthcare nanotech nanoscale cochlear drug delivery, by geography ($m), 2007-14 99

Table 4.30: Global healthcare nanotech drug delivery using nanoparticles market, by product ($m), 2007-14 100

Table 4.31: Global healthcare nanotech drug delivery using nanoparticles market, by geography ($m), 2007-14 100

Table 4.32: Global drug delivery using nanocrystals market, by geography ($m), 2007-14 102

Table 4.33: Global healthcare nanotech drug delivery coatings market, by geography ($m), 2007- 14 103

Table 4.34: Global healthcare nanopores market, by geography ($m), 2007-14 104

Table 4.35: Global healthcare nanocomposites market, by geography ($m), 2007-14 104

Table 4.36: Global healthcare nanotech nanotransponder market, by geography ($m), 2007-14 105

Table 4.37: Global healthcare nanotech biocompatible implants and coatings market, by products ($m), 2007-14 107

Table 4.38: Global healthcare nanotech biocompatible implants and coatings market, by geography ($m), 2007-14 107

Table 4.39: Global healthcare nanotech surface modification market, by geography ($m), 2007-14 110

Table 4.40: Global healthcare nanotech device coating market, by products ($m), 2007-14 111

Table 4.41: Global healthcare nanotech device coating market, by geography ($m), 2007-14 111

Table 4.42: Global healthcare nanotech implants market, by geography ($m), 2007-14 116

Table 4.43: Global healthcare nanotech regenerative medicine and wound care market, by products

($m), 2007-14 119

Table 4.44: Global healthcare nanotech regenerative medicine market, by product ($m), 2007-14 120

Table 4.45: Global healthcare nanotech wound care market, by products ($m), 2007-14 124

Table 4.46: Global healthcare nanotech diagnostics market, by products ($m), 2007-14 126

Table 4.47: Global healthcare nanotech diagnostics market, by geography ($m), 2007-14 127

Table 0.48: US patents 184

Table 0.49: US patents (ctd 1) 185

Table 0.50: US patents (ctd 2) 186

Table 0.51: US patents (ctd 3) 187

Table 0.52: US patents (ctd 4) 188

Table 0.53: US patents (ctd 5) 189

Table 0.54: US patents (ctd 6) 190

Table 0.55: US patents (ctd 7) 191

Table 0.56: US patents (ctd 8) 192

Table 0.57: US patents (ctd 9) 193

Table 0.58: US patents (ctd 10) 194

Table 0.59: US patents (ctd 11) 195

Table 0.60: US patents (ctd 12) 196

Table 0.61: US patents (ctd 13) 197

Table 0.62: US patents (ctd 14) 198

Table 0.63: US patents (ctd 15) 199

Table 0.64: US patents (ctd 16) 200

Table 0.65: US patents (ctd 17) 201

Table 0.66: US patents (ctd 18) 202

Table 0.67: US patents (ctd 19) 203

Table 0.68: Europe patents 204

Table 0.69: Europe patents (ctd 1) 205

Table 0.70: Europe patents (ctd 2) 206

Table 0.71: Europe patents (ctd 3) 207

Table 0.72: Europe patents (ctd 4) 208

Table 0.73: Europe patents (ctd 5) 209

Table 0.74: Europe patents (ctd 6) 210

Table 0.75: Europe patents (ctd 7) 211

Table 0.76: Europe patents (ctd 8) 212

Table 0.77: Europe patents (ctd 9) 213

Table 0.78: Europe patents (ctd 10) 214

Table 0.79: Europe patents (ctd 11) 215

Table 0.80: Japan patents 216

Table 0.81: Japan patents (ctd 1) 217

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