Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Carbon Nanotubes Continue To Show Promise in Battle Against Cancer

Abstract:
Carbon nanotubes, one of the original engineered nanomaterials, also may prove to be among the most versatile, as numerous teams of investigators continue to develop novel nanotube-based therapeutic and diagnostic tools. Over the past month, three new research papers have highlighted the potential of nanotubes as weapons against cancer.

Carbon Nanotubes Continue To Show Promise in Battle Against Cancer

Bethesda, MD | Posted on June 27th, 2009

Reporting its work in the journal Biomacromolecules, a group headed by James R. Baker, Jr., M.D., University of Michigan, describes its success in linking single-molecule nanoparticles known as dendrimers to the surface of multiwalled carbon nanotubes. The resulting combination nanomaterial is highly stable, readily disperses in water, and is biocompatible.

The dendrimers that Dr. Baker's group uses function as targeting agents that deliver the nanotubes specifically to tumor cells that overexpress high-affinity folic acid receptors. Although other research teams also have developed methods for targeting nanotubes to tumors, this approach holds particular promise because dendrimers also can be modified to carry drugs and imaging agents as well as targeting agents. As a result, explained Dr. Baker, who heads one of the 12 National Cancer Institute Cancer Nanotechnology Platform Partnerships, this current research provides a one-step method for adding multiple functions to carbon nanotubes without the need for developing complex new methods for modifying the nanotubes.

Efforts to develop carbon nanotubes for use in cancer applications also received a boost from work presented in a set of two papers published in the Journal of Biomedical Optics. In these papers, a team of investigators led by Alex Biris, Ph.D., and Vladimir P. Zharov, Ph.D., D.Sc., University of Arkansas at Little Rock, describes methods for detecting, tracking, and killing cancer cells in real time with carbon nanotubes.

In their first paper, the investigators demonstrate that they can use a technique known as Raman spectroscopy to track carbon nanotubes as they move through a living animal. "Until now, nobody has been able to fully understand and study in vivo and in real time how these nanoparticles travel through a living system," said Dr. Biris. "By using Raman spectroscopy, we showed that it is possible not only to monitor and detect nanomaterials moving through the circulation, but also to detect single cancer cells tagged with carbon nanotubes. In this way, we can measure their clearance rate and their biodistribution kinetics through the lymph and blood systems."

Dr. Zharov emphasized that in vivo Raman flow cytometry is promising for the detection and identification of a broad spectrum of various nanoparticles with strong Raman scattering properties, such as cells, bacteria, and even viruses. "Before any clinical application of nanoparticles, it is imperative to determine their pharmacological profiles," he said. "This tool will provide this function as a supplement or even as an alternative to the existing methods."

In this project, Drs. Biris and Zharov and colleague Ekaterina I. Galanzha, M.D., injected a single human cancer cell containing carbon nanotube material in the tail vein of a test rat. They were able to follow the circulation of the carbon nanotubes in the blood vessels to the rat's ear, tracking the cell through the rat's bloodstream, lymphatic system, and tissue with a Raman spectrometer.

In their second paper, Drs. Biris and Zharov show that once carbon nanotubes reach tumors and their location is pinpointed using another technique known as time-resolved infrared thermal imaging, the nanotubes can be turned into miniature heaters through laser irradiation. The hot nanotubes then bake the tumors to death from the inside out. This set of experiments demonstrates that the cancer-killing process affects only the nanotube-labeled cancer cells, which disintegrate and die within a matter of hours after treatment. The investigators believe that this approach could be particularly useful for treating small tumors, tumor margins, and micrometastases.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Multifunctional dendrimer-modified multiwalled carbon nanotubes: synthesis, characterization, and in vitro cancer cell targeting and imaging.”

View abstract 1 - “In vivo Raman flow cytometry for real-time detection of carbon nanotube kinetics in lymph, blood, and tissues.”

View abstract 2 - “Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imaging.”

Related News Press

News and information

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Gene therapy relieves back pain, repairs damaged disc in mice: Study suggests nanocarriers loaded with DNA could replace opioids May 17th, 2024

Shedding light on perovskite hydrides using a new deposition technique: Researchers develop a methodology to grow single-crystal perovskite hydrides, enabling accurate hydride conductivity measurements May 17th, 2024

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in cuprate superconductor May 17th, 2024

Govt.-Legislation/Regulation/Funding/Policy

International research team uses wavefunction matching to solve quantum many-body problems: New approach makes calculations with realistic interactions possible May 17th, 2024

Aston University researcher receives £1 million grant to revolutionize miniature optical devices May 17th, 2024

NRL charters Navy’s quantum inertial navigation path to reduce drift April 5th, 2024

Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024

Nanotubes/Buckyballs/Fullerenes/Nanorods/Nanostrings

Catalytic combo converts CO2 to solid carbon nanofibers: Tandem electrocatalytic-thermocatalytic conversion could help offset emissions of potent greenhouse gas by locking carbon away in a useful material January 12th, 2024

TU Delft researchers discover new ultra strong material for microchip sensors: A material that doesn't just rival the strength of diamonds and graphene, but boasts a yield strength 10 times greater than Kevlar, renowned for its use in bulletproof vests November 3rd, 2023

Tests find no free-standing nanotubes released from tire tread wear September 8th, 2023

Detection of bacteria and viruses with fluorescent nanotubes July 21st, 2023

Nanomedicine

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Advances in priming B cell immunity against HIV pave the way to future HIV vaccines, shows quartet of new studies May 17th, 2024

New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024

Discoveries

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Finding quantum order in chaos May 17th, 2024

Advances in priming B cell immunity against HIV pave the way to future HIV vaccines, shows quartet of new studies May 17th, 2024

Announcements

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Finding quantum order in chaos May 17th, 2024

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in cuprate superconductor May 17th, 2024

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project