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Home > Press > Nanotechnology Applied to Clinical Biomarker Medicine, L. Liotta

Lance Liotta
Professor
George Mason University
Lance Liotta
Professor
George Mason University

Abstract:
Lance Liotta, Professor at George Mason University, provides Nano World News with a preview of his upcoming presentation at NSTI Nanotech 2008, and he shares with regards developments related to the technology.

Nanotechnology Applied to Clinical Biomarker Medicine, L. Liotta

Cambridge, MA | Posted on March 23rd, 2008

There is a tremendous need to find novel biomarkers for sensitive and specific disease detection that will lead to a dramatic improvement in treatment outcome. Biomarkers are nucleic acids, small proteins, protein fragments, and metabolites indicative of a specific biological state that are associated with the risk of the contraction or presence of disease. Two major hurdles have prevented biomarker discovery from reaching clinical benefits: 1) biomarkers exist in exceedingly low concentrations within complex mixtures of high-abundance proteins such as albumin; 2) degradation of protein biomarkers can occur immediately following the collection of blood or body fluid as a result of endogenous or exogenous proteinases. We have introduced a charged based affinity bait molecule into N-isopropylacrylamide to produce a particle that will perform three independent functions within minutes, in one step, in solution: (a) molecular size sieving, (b) affinity capture of all solution-phase target molecules, and (c) complete protection of harvested proteins from enzymatic degradation. The captured analytes can be completely eluted from particles and are totally compatible with mass spectrometry analysis and immunoassays.

Development of Technology

This technology is being tuned to harvest and concentrate specific protein molecules out of biological fluids like blood, urine, etc. Interesting targets are known disease biomarkers like platelet derived growth factor (PDGF) or other analytes like human growth hormone (hGH) that are too rare or labile to be detected with regular clinics technology, or whose handling is currently too expensive.

Moreover, new kinds of baits are being explored, like classes of reactive dyes used in the past for affinity chromatography, in order to obtain a general affinity bait for proteins that is independent from protein charge.

The ability of hydrogel nanoparticles technology to perform a) molecular sieving, b) analytes concentration and c) protection from degradation in one step, very rapidly, and in solution is being extended to other realms beyond proteomics. Beads loaded with β-cyclodextrin are being obtained to exploit the known affinity of cyclodextrins for small metabolites to extend the use of particles to the field of metabolomics. Particles carrying boronic acid moieties are being designed and synthesized in order selectively target polysaccharides and glycopeptides in body fluids.

Dr. Liotta acknowledges the work of Dr. Alessandra Luchini, who was the author of the first publication on smart hydrohel particles: biomarker harvesting.

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About NSTI
The Nano Science and Technology Institute (NSTI) is chartered with the promotion and integration of nano and other advanced technologies through education, technology and business development. NSTI accomplishes this mission through its offerings of continuing education programs, scientific and business publishing and community outreach. NSTI produces the annual Nanotech conference and trade show, the most comprehensive international nanotechnology convention in the world. NSTI also produces the semi-annual Nanotech Venture, Nanotech Industrial Impact Workshop, Nano Impact Summit and the Nanotech Course Series in the US and Europe. NSTI was founded in 1997 as a result of the merger between various scientific societies, and is headquartered in Cambridge, Massachusetts with additional offices in California and Switzerland.

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