Nanotechnology Now - Press Release: Researchers from the California NanoSystems Institute at UCLA have created a new technique that greatly enhances digital microscopy images

Home > Press > Researchers from the California NanoSystems Institute at UCLA have created a new technique that greatly enhances digital microscopy images

The image sensor of the wavelength scanning super-resolution apparatus collects a “stack” of images of the sample.

Ozcan Lab

Abstract:
The development is significant because digital imagery has led to many advances in microscopy, but digital microscopic imaging can sometimes result in blurry, pixelated images.

Researchers from the California NanoSystems Institute at UCLA have created a new technique that greatly enhances digital microscopy images

Los Angeles, CA | Posted on January 27th, 2016

The new technique is called wavelength scanning pixel super-resolution. It uses a device that captures a stack of digital images of the same specimen, each with a slightly different wavelength of light. Then, researchers apply a newly devised algorithm that divides the pixels in each captured image into a number of smaller pixels, resulting in a much higher-resolution digital image of the specimen.

The research team was led by Aydogan Ozcan, Chancellor’s Professor of Electrical Engineering and Bioengineering at the UCLA Henry Samueli School of Engineering and Applied Science.The study appears in the journal Light: Science and Applications, which is published by the Nature Publishing Group.

“These results mean we can see and inspect large samples with finer details at the sub-micron level,” Ozcan said. “We have applied this method to lens-based conventional microscopes, as well as our lensless on-chip microscopy systems that create microscopic images using holograms, and it works across all these platforms.”

The benefits of this new method are wide-ranging, but especially significant in pathology, where rapid microscopic imaging of large numbers of tissue or blood cells is key to diagnosing diseases such as cancer. The specimens used in the study were blood samples, used to screen for various diseases, and Papanicolaou tests, which are used to screen for cervical cancer.

Ozcan said that wavelength scanning super-resolution works on both colorless and dye-stained samples. The entire apparatus fits on a desktop, so its size and convenience could be of great benefit to doctors and scientists using microscopes in resource-limited settings such as clinics in developing countries.

The first author of the study was UCLA graduate student Wei Luo; the other authors were graduate students Yibo Zhang and Alborz Feizi and postdoctoral scholar Zoltan Gorocs.

Some experiments for this research were conducted at the Nano and Pico Characterization Lab at the California NanoSystems Institute at UCLA.

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About UCLA
UCLA is an international leader in the breadth and quality of its academic, research, health care, cultural, continuing education and athletics programs. With more than 43,300 undergraduate and graduate students, it is the largest university in California. The UCLA College and 11 professional schools offer more than 5,000 courses, 124 undergraduate majors and 91 minors, 98 master’s programs, and 109 doctoral and professional programs. Seven alumni and six faculty have been awarded the Nobel Prize.

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Contacts:
Shaun Mason
Manager of Communications and Proposal Services
California NanoSystems Institute
University of California, Los Angeles
310-794-5346
Facebook: https://www.facebook.com/CNSI.UCLA?ref=hl
Twitter: @cnsi_ucla

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