Home > Press > Polymeric Nanocarriers Improve Performance of Anticancer Drugs
Abstract:
Academic researchers in Iran used biodegradable polymers to produce drug nanocarriers able to carry and release a type of anticancer drug in cancerous cells.
The research was carried out to develop the applications of these types of drugs and produce and coat magnetic nanoparticles with biocompatible copolymers as an appropriate bed for doxorubicin anticancer drug.
According to the executor of the plan, the copolymer used in this research is biocompatible and non-toxic and can be degraded in the chemical atmosphere for the body. In addition, the loading of doxorubicin increases due to the ease of synthesis, the wide and controllable range of particle size, hydrophilicity and the ability to create physical and chemical bonds with the drug. These characteristics have resulted in an increase in the efficiency of the drug to the extent that significant increase is observed the release of this drug in cancerous cells in comparison with other reported products. This drug can be easily controlled due to its magnetic properties.
The mechanism of drug carrying nanosystems can be explained this way; nanoparticles can diffuse into the cell by passing through cellular blocks (such as membranes) due to their small size, and they increase the accumulation of the drug in the target tissue. This way, the toxicity of drugs decreases because only the target cells are affected. Therefore, no side effect is observed in other healthy tissues and the treatment period increases.
Results showed that due to their specific characteristics, including high LCST (low critical solution temperature), the copolymers are capable of loading and releasing the drugs in comparison with previous reported products such as poly (N-isopropylacrylamide). In addition, copolymers can be produced easily through this method and they do not require specific conditions. Moreover, they have acceptable compatibility with the environment and are degradable.
Results of the research have been published in Applied Surface Science, vol. 320, issue 1, 2014, pp. 301-308.
####
For more information, please click here
Copyright © Fars News Agency
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Related News Press |
News and information
Simulating magnetization in a Heisenberg quantum spin chain April 5th, 2024
NRL charters Navy’s quantum inertial navigation path to reduce drift April 5th, 2024
Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024
Good as gold - improving infectious disease testing with gold nanoparticles April 5th, 2024
Cancer
New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024
Super-efficient laser light-induced detection of cancer cell-derived nanoparticles: Skipping ultracentrifugation, detection time reduced from hours to minutes! October 6th, 2023
Nanomedicine
New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024
Good as gold - improving infectious disease testing with gold nanoparticles April 5th, 2024
Researchers develop artificial building blocks of life March 8th, 2024
Discoveries
Chemical reactions can scramble quantum information as well as black holes April 5th, 2024
New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024
Utilizing palladium for addressing contact issues of buried oxide thin film transistors April 5th, 2024
Materials/Metamaterials/Magnetoresistance
Nanoscale CL thermometry with lanthanide-doped heavy-metal oxide in TEM March 8th, 2024
Focused ion beam technology: A single tool for a wide range of applications January 12th, 2024
Announcements
NRL charters Navy’s quantum inertial navigation path to reduce drift April 5th, 2024
Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024
Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters
Simulating magnetization in a Heisenberg quantum spin chain April 5th, 2024
Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024
The latest news from around the world, FREE | ||
Premium Products | ||
Only the news you want to read!
Learn More |
||
Full-service, expert consulting
Learn More |
||