Home > Press > DNA-Based Biosensor Helps Better Designing of Anticancer Drugs
Abstract:
Iranian researchers from Isfahan University of Technology produced a DNA-based biosensor to better understand the performance of anticancer drugs.
DNA-Based Biosensor Helps Better Designing of Anticancer Drugs
Tehran, Iran | Posted on January 10th, 2015Results of the research can be used by pharmacists in designing and producing new anticancer drugs.
The production of DNA-based biosensors has grown in recent years. However, very few studies have been carried out to understand interactions between the drugs and DNA, although the better understanding of mechanisms of interactions between drug and DNA results in the designing of new efficient drugs and their screening at laboratorial scale.
Mitomycin C (MMC) is one of the most important and commonly-used anticancer drugs. This drug is used in the treatment of stomach, pancreas and large intestine cancers. This research studies interaction of the drug and double string DNA (ds-DNA).
In this study, a biosensor has been designed and its surface has been modified with ds-DNA and carbon nanotubes. The researchers studied the possibility of using electrochemical method in the evaluation of anticancer properties of MMC as a sample of anticancer drugs by using voltammetric and electrochemical impedance spectroscopy.
Results of the research showed that MMC drug does not have any significant effect on DNA, and it needs to be activated to have interaction with DNA. According to the designed tests, this objective can be achieved by reducing the drug in an acidic media.
These types of research will result in the creation of fundamental changes in the diagnosis and determination of the amount of anticancer drugs, cancerous compounds and studying their mechanisms.
The results of the research have been published in Biosensors and Bioelectronics, vol. 59, issue 1, 2014, pp. 282-289.
####
For more information, please click here
Copyright © Fars News Agency
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Bookmark:
| Related News Press |
News and information
Quantum computer improves AI predictions April 17th, 2026
Flexible sensor gains sensitivity under pressure April 17th, 2026
A reusable chip for particulate matter sensing April 17th, 2026
Detecting vibrational quantum beating in the predissociation dynamics of SF6 using time-resolved photoelectron spectroscopy April 17th, 2026
Cancer
New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025
Ben-Gurion University of the Negev researchers several steps closer to harnessing patient's own T-cells to fight off cancer June 6th, 2025
Self-propelled protein-based nanomotors for enhanced cancer therapy by inducing ferroptosis June 6th, 2025
Nanomedicine
A fundamentally new therapeutic approach to cystic fibrosis: Nanobody repairs cellular defect April 17th, 2026
New molecular technology targets tumors and simultaneously silences two ‘undruggable’ cancer genes August 8th, 2025
New imaging approach transforms study of bacterial biofilms August 8th, 2025
Electrifying results shed light on graphene foam as a potential material for lab grown cartilage June 6th, 2025
Discoveries
Quantum computer improves AI predictions April 17th, 2026
Flexible sensor gains sensitivity under pressure April 17th, 2026
A reusable chip for particulate matter sensing April 17th, 2026
Detecting vibrational quantum beating in the predissociation dynamics of SF6 using time-resolved photoelectron spectroscopy April 17th, 2026
Announcements
A fundamentally new therapeutic approach to cystic fibrosis: Nanobody repairs cellular defect April 17th, 2026
UC Irvine physicists discover method to reverse ‘quantum scrambling’ : The work addresses the problem of information loss in quantum computing system April 17th, 2026
Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters
A fundamentally new therapeutic approach to cystic fibrosis: Nanobody repairs cellular defect April 17th, 2026
UC Irvine physicists discover method to reverse ‘quantum scrambling’ : The work addresses the problem of information loss in quantum computing system April 17th, 2026
 |
||
 |
||
| The latest news from around the world, FREE | ||
 |
||
|
|
||
| Premium Products | ||
 |
||
|
Only the news you want to read!
Learn More |
||
 |
||
|
Full-service, expert consulting
Learn More |
||
|
|
||