Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Nanoparticles in polluted air, smoke & nanotechnology products have serious impact on health: Trinity College Dublin scientists establish link between autoimmune diseases such as rheumatoid arthritis and nanoparticles

Abstract:
New groundbreaking research by scientists at Trinity College Dublin has found that exposure to nanoparticles can have a serious impact on health, linking it to rheumatoid arthritis and the development of other serious autoimmune diseases. The findings that have been recently published in the international journal 'Nanomedicine' have health and safety implications for the manufacture, use and ultimate disposal of nanotechnology products and materials. They also identified new cellular targets for the development of potential drug therapies in combating the development of autoimmune diseases.

Nanoparticles in polluted air, smoke & nanotechnology products have serious impact on health: Trinity College Dublin scientists establish link between autoimmune diseases such as rheumatoid arthritis and nanoparticles

Dublin, Ireland | Posted on June 11th, 2012

Environmental pollution including carbon particles emitted by car exhaust, smoking and long term inhalation of dust of various origins have been recognised as risk factors causing chronic inflammation of the lungs. The link between smoking and autoimmune diseases such as rheumatoid arthritis has also been established. This new research now raises serious concerns in relation to similar risks caused by nanotechnology products which if not handled appropriately may contribute to the generation of new types of airborne pollutants causing risks to global health.

In their research, the Nanomedicine and Molecular Imaging team at Trinity College Dublin's School of Medicine led by Professor of Molecular Medicine, Yuri Volkov investigated whether there was a common underlying mechanism contributing to the development of autoimmune diseases in human cells following their exposure to a wide range of nanoparticles containing different physical and chemical properties.

The scientists applied a wide range of nanomaterials including ultrafine carbon black, carbon nanotubes and silicon dioxide particles of different sizes, ranging from 20 to 400 nanometres, to human cells derived from the lining of the airway passages, and to the cells of so-called phagocytic origin − those cells that are most frequently exposed to the inhaled foreign particles or are tasked with cleaning up our body from them. At the same time, collaborating researchers from the Health Effects Laboratory Division, National Institute for Occupational Safety & Health (Morgantown, WV, USA) have conducted the studies in mice exposed to chronic inhalation of air contaminated with single walled carbon nanotubes.

The result was clear and convincing: all types of nanoparticles in both the TCD and US study were causing an identical response in human cells and in the lungs of mice, manifesting in the specific transformation of the amino acid arginine into the molecule called citrulline which can lead to the development of autoimmune conditions such as rheumatoid arthritis.

In the transformation to citrulline, human proteins which incorporate this modified amino acid as building blocks, can no longer function properly and are subject to destruction and elimination by the bodily defence system. Once programmed to get rid of citrullinated proteins, the immune system can start attacking its own tissues and organs, thereby causing the autoimmune processes which may result in rheumatoid arthritis.

Commenting on the significance of the findings, TCD's Professor Volkov says: "The research establishes a clear link between autoimmune diseases and nanoparticles. Preventing or interfering with the resulting citrullination process looks therefore as a promising target for the development of future preventative and therapeutic approaches in rheumatoid arthritis and possibly other autoimmune conditions."

####

For more information, please click here

Contacts:
Professor Yuri Volkov

353-863-732-946

Copyright © Trinity College Dublin

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

The paper's full title published in the 'Nanomedicine' journal (Future Medicine journals group) is "Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo":

Related News Press

News and information

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Gene therapy relieves back pain, repairs damaged disc in mice: Study suggests nanocarriers loaded with DNA could replace opioids May 17th, 2024

Shedding light on perovskite hydrides using a new deposition technique: Researchers develop a methodology to grow single-crystal perovskite hydrides, enabling accurate hydride conductivity measurements May 17th, 2024

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in cuprate superconductor May 17th, 2024

Discoveries

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Finding quantum order in chaos May 17th, 2024

Advances in priming B cell immunity against HIV pave the way to future HIV vaccines, shows quartet of new studies May 17th, 2024

Announcements

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Finding quantum order in chaos May 17th, 2024

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in cuprate superconductor May 17th, 2024

Environment

$900,000 awarded to optimize graphene energy harvesting devices: The WoodNext Foundation's commitment to U of A physicist Paul Thibado will be used to develop sensor systems compatible with six different power sources January 12th, 2024

Catalytic combo converts CO2 to solid carbon nanofibers: Tandem electrocatalytic-thermocatalytic conversion could help offset emissions of potent greenhouse gas by locking carbon away in a useful material January 12th, 2024

New catalyst could dramatically cut methane pollution from millions of engines: Researchers demonstrate a way to remove the potent greenhouse gas from the exhaust of engines that burn natural gas. July 21st, 2023

Billions of nanoplastics released when microwaving baby food containers: Exposure to plastic particles kills up to 75% of cultured kidney cells July 21st, 2023

Safety-Nanoparticles/Risk management

First human trial shows ‘wonder’ material can be developed safely: A revolutionary nanomaterial with huge potential to tackle multiple global challenges could be developed further without acute risk to human health, research suggests February 16th, 2024

New research may make future design of nanotechnology safer with fewer side effects: Study shows a promising strategy to reduce adverse reactions to nanoparticles by using complement inhibitors October 6th, 2023

Tests find no free-standing nanotubes released from tire tread wear September 8th, 2023

Billions of nanoplastics released when microwaving baby food containers: Exposure to plastic particles kills up to 75% of cultured kidney cells July 21st, 2023

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project