Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Large-Scale Screening of Nanomaterial Toxicity and Activity

Abstract:
As researchers develop an ever-expanding toolkit of nanoparticles for use as drug and imaging agent delivery vehicles, there is a growing need to understand how a given nanoparticle's physical and chemical properties affect biological activity and toxicity. Now, two researchers working independently of one another have develop new methods for measuring the biological activity of nanomaterials in a highly systematic manner that enable them to draw important insights about nanomaterial biologic activity.

Large-Scale Screening of Nanomaterial Toxicity and Activity

Bethesda , MD | Posted on June 16th, 2008

Reporting its work in the Proceedings of the National Academy of Sciences of the United States of America, a research group lead by Ralph Weissleder, M.D., Ph.D., co-principal investigator of the MIT-Harvard Center of Cancer Nanotechnology Excellence, and Stuart Schreiber, Ph.D., of the Broad Institute of Harvard and MIT, describes its development of a broad panel of in vitro assays that measure a variety of nanoparticle properties. They then use a technique known as hierarchical clustering that identifies nanomaterials that have similar biological effects across a wide range of assays. This approach enabled the investigators to create strong structure-activity relationships that correlate nanoparticle properties to biological activities.

In the experiments reported in this paper, the investigators tested some 50 different nanomaterials. They used four different cell lines for their assays and measured biological activity at four different nanoparticle doses. The large amount of data generated by this type of extensive analysis enabled the researchers to identify different relationships with a high degree of statistical significance. This analysis clearly showed that there were definite correlations between the physical and chemical properties of a nanoparticle and biological activity. More importantly, the investigators found that the relationships identified using in vitro assays correlated with activity observed when the nanoparticles were administered to test animals.

Taking a similar approach, Nicholas Kotov, Ph.D., of the University of Michigan and Yurii Gun'ko, Ph.D., of Trinity College Dublin, led a team of investigators that developed a series of high-content screening assays for use in testing the cytotoxicity of a large number of quantum dots and gold nanoparticles. These assays, the researchers note, enabled them to distinguish subtle differences in cytotoxicity among similar nanomaterials, which should set the stage for conducting multiparametric analyses on large numbers of particles in a rapid and quantitative manner. The investigators are now working to modify their assay protocols to include biological properties such as transport across the cell membrane.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:


National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Perturbational Profiling of Nanomaterial Biologic Activity.”

View abstract - “High-Content Screening as a Universal Tool for Fingerprinting of Cytotoxicity of Nanoparticles.”

Related News Press

News and information

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Gene therapy relieves back pain, repairs damaged disc in mice: Study suggests nanocarriers loaded with DNA could replace opioids May 17th, 2024

Shedding light on perovskite hydrides using a new deposition technique: Researchers develop a methodology to grow single-crystal perovskite hydrides, enabling accurate hydride conductivity measurements May 17th, 2024

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in cuprate superconductor May 17th, 2024

Nanomedicine

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Advances in priming B cell immunity against HIV pave the way to future HIV vaccines, shows quartet of new studies May 17th, 2024

New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024

Announcements

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Finding quantum order in chaos May 17th, 2024

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in cuprate superconductor May 17th, 2024

Tools

First direct imaging of small noble gas clusters at room temperature: Novel opportunities in quantum technology and condensed matter physics opened by noble gas atoms confined between graphene layers January 12th, 2024

New laser setup probes metamaterial structures with ultrafast pulses: The technique could speed up the development of acoustic lenses, impact-resistant films, and other futuristic materials November 17th, 2023

Ferroelectrically modulate the Fermi level of graphene oxide to enhance SERS response November 3rd, 2023

The USTC realizes In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors November 3rd, 2023

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project