Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > DNA origami to scale-up molecular motors

Mixing DNA-modified microtubules, DNA origami and kinesin linkers leads to star-like formations of microtubules that are connected by kinesin linkers. This network contracted dynamically when ATP energy was added. 
(Matsuda K. et al., Nano Letters, April 30, 2019)
Mixing DNA-modified microtubules, DNA origami and kinesin linkers leads to star-like formations of microtubules that are connected by kinesin linkers. This network contracted dynamically when ATP energy was added. (Matsuda K. et al., Nano Letters, April 30, 2019)

Abstract:
Researchers have successfully used DNA origami to make smooth-muscle-like contractions in large networks of molecular motor systems, a discovery which could be applied in molecular robotics.

DNA origami to scale-up molecular motors

Tokyo, Japan | Posted on June 13th, 2019

"We successfully demonstrated programmed self-assembly of a biomolecular motor system," write the researchers from Japan and Germany who conducted the study.

The biomolecular motor system, consisting of fibrous microtubules and motor protein kinesins, plays an essential role in cellular transportation systems. Scientists believe they can utilize the motors in molecular robotics but it remains difficult to assemble a larger system from the tiny molecules.

In the current study published in Nano Letters, the research team including Akira Kakugo of Hokkaido University, Akinori Kuzuya of Kansai University, and Akihiko Konagaya of Tokyo Institute of Technology developed a system combining DNA origami and microtubules. The DNA origami were formed from six DNA helices bundled together. Mixing the two components caused the microtubules to self-assemble around the DNA origami forming star-shaped structures. This self-assembly was made possible by the binding of complementary DNA strands attached to each component.

The team then designed a "kinesin linker" which is made of four kinesin motor proteins radiating from a central core protein. These kinesin linkers joined the microtubules together, causing multiple star-like assemblies to connect, forming a much larger hierarchical network.

When adenosine triphosphate (ATP), a molecule which stores and carries energy, was added to the system, the kinesin linkers moved, causing the microtubular network to dynamically contract within a matter of minutes. This resembled the contraction of smooth muscles according to the researchers.

This dynamic contraction only happened when the DNA origami were present, suggesting the importance of the hierarchical assembly within the microtubular network. "Further studies could lead to the use of DNA for controlled, programmable self-assembly and contraction of biomolecular motors. Such motors could find applications in molecular robotics and the development of microvalves for microfluidic devices," says Akira Kakugo.

Reference

Authors :
Kento Matsuda1, Arif Md. Rashedul Kabir2, Naohide Akamatsu3, Ai Saito1, Shumpei Ishikawa3, Tsuyoshi Matsuyama3, Oliver Ditzer4, Md. Sirajul Islam5, Yuichi Ohya3,5, Kazuki Sada1,2, Akihiko Konagaya6, Akinori Kuzuya3,5,*, and Akira Kakugo1,2,*
Title of original paper :
Artificial Smooth Muscle Model Composed of Hierarchically Ordered Microtubule Asters Mediated by DNA Origami Nanostructures.
Journal :
Nano Letters
DOI :
10.1021/acs.nanolett.9b01201 outer
Affiliations :
1Graduate School of Chemical Sciences and Engineering, Hokkaido University

2Faculty of Science, Hokkaido University

3Department of Chemistry and Materials Engineering, Kansai University

4Faculty of Chemistry and Food Chemistry, Technische Universität Dresden

5Organization for Research and Development of Innovative Science and Technology, Kansai University

6Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology

####

For more information, please click here

Contacts:
Further Information

Professor Akihiko Konagaya

School of Computing, Tokyo Institute of Technology

Email
Tel +81-45-924-5655

Contact

Public Relations Section, Tokyo Institute of Technology

Email
Tel +81-3-5734-2975

*Corresponding authors' email:

Copyright © Tokyo Institute of Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Lehigh University to lead ‘integrative partnerships’ for multi-university research collaboration in advanced optoelectronic material development: 5-year, $25 million NSF investment in IMOD, a revolutionary center for optoelectronic, quantum technologies September 10th, 2021

Engineering various sources of loss provides new features for perfect light absorption: "Loss is ubiquitous in nature, and by better understanding it, we make it more useful" September 10th, 2021

New substance classes for nanomaterials: Nano spheres and diamond slivers made of silicon and germanium: Potential applications as nano semiconductor materials September 10th, 2021

‘Anti-rust’ coating for plants protects against disease with cellulose nanofiber: Researchers from the University of Tsukuba find that coating soybean plant leaves with cellulose nanofiber offers resistance to infection by Asian soybean rust pathogen September 10th, 2021

Robotics

Leibniz Prize winner Professor Dr. Oliver G. Schmidt moves to Chemnitz University of Technology: President Professor Dr. Gerd Strohmeier refers to an 'absolute top transfer' September 10th, 2021

Actuator discovery outperforms existing technology: University of Houston researchers use organic semiconductor nanotubes to create new electrochemical actuator September 3rd, 2021

Videos/Movies

The National Space Society Joins the Progressive Policy Institute in Supporting Rapid Development of Space Solar Power: Orbiting Solar Power Stations Would Help to Save the Environment August 20th, 2021

Scientists create rechargeable swimming microrobots using oil and water July 16th, 2021

Scientists take first snapshots of ultrafast switching in a quantum electronic device: They discover a short-lived state that could lead to faster and more energy-efficient computing devices July 16th, 2021

Rice lab peers inside 2D crystal synthesis: Simulations could help molecular engineers enhance creation of semiconducting nanomaterials June 11th, 2021

Possible Futures

‘Anti-rust’ coating for plants protects against disease with cellulose nanofiber: Researchers from the University of Tsukuba find that coating soybean plant leaves with cellulose nanofiber offers resistance to infection by Asian soybean rust pathogen September 10th, 2021

Leibniz Prize winner Professor Dr. Oliver G. Schmidt moves to Chemnitz University of Technology: President Professor Dr. Gerd Strohmeier refers to an 'absolute top transfer' September 10th, 2021

Ultrafast & ultrathin: new physics professor at TU Dresden makes mysterious quantum world visible September 10th, 2021

Stretching the capacity of flexible energy storage September 10th, 2021

Molecular Machines

Nanotech scientists create world's smallest origami bird March 17th, 2021

Controlling the speed of enzyme motors brings biomedical applications of nanorobots closer: Recent advances in this field have made micro- and nanomotors promising devices for solving many biomedical problems October 13th, 2020

Giant nanomachine aids the immune system: Theoretical chemistry August 28th, 2020

Kavli Lectures: The art of building small and innovating for industrial impact August 7th, 2020

Molecular Nanotechnology

Nanotech scientists create world's smallest origami bird March 17th, 2021

Light-controlled nanomachine controls catalysis: A molecular motor enables the speed of chemical processes to be controlled using light impulses November 23rd, 2020

Controlling the speed of enzyme motors brings biomedical applications of nanorobots closer: Recent advances in this field have made micro- and nanomotors promising devices for solving many biomedical problems October 13th, 2020

Big energy savings for tiny machines May 24th, 2019

Self Assembly

3D design leads to first stable and strong self-assembling 1D nanographene wires April 6th, 2021

DNA--Metal double helix: Single-stranded DNA as supramolecular template for highly organized palladium nanowires March 26th, 2021

Advancement creates nanosized, foldable robots March 19th, 2021

Building tough 3D nanomaterials with DNA: Columbia Engineers use DNA nanotechnology to create highly resilient synthetic nanoparticle-based materials that can be processed through conventional nanofabrication methods March 19th, 2021

Discoveries

Cheaper hydrogen production: Efficient water and urea electrolysis with bimetallic yolk-shell nanoparticles September 10th, 2021

Lehigh University to lead ‘integrative partnerships’ for multi-university research collaboration in advanced optoelectronic material development: 5-year, $25 million NSF investment in IMOD, a revolutionary center for optoelectronic, quantum technologies September 10th, 2021

New substance classes for nanomaterials: Nano spheres and diamond slivers made of silicon and germanium: Potential applications as nano semiconductor materials September 10th, 2021

‘Anti-rust’ coating for plants protects against disease with cellulose nanofiber: Researchers from the University of Tsukuba find that coating soybean plant leaves with cellulose nanofiber offers resistance to infection by Asian soybean rust pathogen September 10th, 2021

Announcements

‘Anti-rust’ coating for plants protects against disease with cellulose nanofiber: Researchers from the University of Tsukuba find that coating soybean plant leaves with cellulose nanofiber offers resistance to infection by Asian soybean rust pathogen September 10th, 2021

Leibniz Prize winner Professor Dr. Oliver G. Schmidt moves to Chemnitz University of Technology: President Professor Dr. Gerd Strohmeier refers to an 'absolute top transfer' September 10th, 2021

Ultrafast & ultrathin: new physics professor at TU Dresden makes mysterious quantum world visible September 10th, 2021

Stretching the capacity of flexible energy storage September 10th, 2021

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Engineering various sources of loss provides new features for perfect light absorption: "Loss is ubiquitous in nature, and by better understanding it, we make it more useful" September 10th, 2021

New substance classes for nanomaterials: Nano spheres and diamond slivers made of silicon and germanium: Potential applications as nano semiconductor materials September 10th, 2021

‘Anti-rust’ coating for plants protects against disease with cellulose nanofiber: Researchers from the University of Tsukuba find that coating soybean plant leaves with cellulose nanofiber offers resistance to infection by Asian soybean rust pathogen September 10th, 2021

Ultrafast & ultrathin: new physics professor at TU Dresden makes mysterious quantum world visible September 10th, 2021

Nanobiotechnology

Leibniz Prize winner Professor Dr. Oliver G. Schmidt moves to Chemnitz University of Technology: President Professor Dr. Gerd Strohmeier refers to an 'absolute top transfer' September 10th, 2021

Imaging single spine structural plasticity at the nanoscale level: Researchers at the Max Planck Florida Institute for Neuroscience (MPFI) have developed a new imaging technique capable of visualizing the dynamically changing structure of dendritic spines with unprecedented resol September 3rd, 2021

Arrowhead Pharmaceuticals to Participate in Upcoming September 2021 Conferences September 1st, 2021

Novel nanotechnology found to enhance fight against colorectal cancer and melanoma: A first-of-its-kind nanotherapeutic delivery system demonstrated remarkable efficacy against both early-stage and difficult-to-treat late-stage metastatic tumors August 13th, 2021

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project