Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Conceptual Nanomedical Lipofuscin Removal Strategy

Nanobotmodels Company with Frank Boehm create image and visualization of "defuscin" nanodevice.
Nanobotmodels Company with Frank Boehm create image and visualization of "defuscin" nanodevice.

Abstract:
(Y. Svidinenko and FJ Boehm - Apr/27/13)

Lipofuscin is a waxy heterogeneous substance that is comprised of aggregates of metabolic cellular waste end products, which reside within the lysosomes and cytosols of particular types of human cells. This substance can neither be degraded further via the typical complement of lysosomal enzymes, nor ejected from cells, but can be somewhat diluted through cell division and subsequent cellular growth. This autofluorescent pigment is considered to be a significant aging-associated "wear-and-tear" compound that is found in the liver, kidney, heart muscle, adrenals, nerve cells and ganglion cells. It is specifically arranged around the cell nucleus, and is a type of lipochrome.

Conceptual Nanomedical Lipofuscin Removal Strategy

Melitopol, Ukraine | Posted on April 29th, 2013

In a broader context, lipofuscin is often considered as one of several forms of undesirable proteinaceous agglomerations; others sometimes called ceroids, inclusion bodies, plaques, or aggresomes, contingent on their source and composition. It accumulates over time within aging cells to become manifest as a significant percentage of a cell's internal volume. As a consequence, it may impede normal cellular processes, affecting proteasomal activity and protein turnover, and is present as typical feature in neurodegenerative diseases as well as aging. Within the aging human brain, deposits of lipofuscin are not uniformly distributed, but rather, are concentrated at specific sites of functional interest. The prevailing thought is that the major source of lipofuscin is derived from the incomplete lysosomal degradation of cell membrane lipids and damaged mitochondria.

It is conceivable that the future development of nanomedical robotics, as described in the upcoming book: Nanomedical Device and Systems Design: Challenges, Possibilities, Visions (FJ Boehm - Editor), to be published on Nov/22/13 by CRC Press (Taylor & Francis) might enable the capacity for the therapeutic removal of lipofuscin from individual cells in massively parallel fashion. Conceptual dedicated autonomous nanodevices (~200 nm in diameter - where one nanometer is a billionth of a meter) might penetrate the cell membranes of neurons and other cells and undertake the removal of lipofuscin through various means, as described in the book excerpt below:

"Although entirely conceptual and seemingly impracticable currently (2013), advanced AI [Artificial Intelligence] involvement in the design/optimization of sophisticated nanomedical devices working in conjunction mature nanomanufacturing may indeed bring about much more complex, albeit far more rapid and efficient lipofuscin detection and removal. Advanced autonomous nanodevices might precisely locate lipofuscin granules by exploiting its strong fluorescence signatures (emission spectrum ranges from 450 to 700 nm)…. to match with onboard reference spectral profiles. The prospective armamentarium at the disposal of these autonomous diamondoid "defuscin" class nanodevices…. might allow for the complete eradication of lipofuscin aggregates utilizing a feedthrough digestive strategy. These entities may be propelled by arrays of oscillating piezoelectric "fins" or via integrated magnetic nanoparticles, which might be activated and controlled externally. The conical inlet port of the nanodevice would be lined with molecules that possess high affinities for A2E [a primary lipofuscin constituent] and other lipofuscin elements. Once a lipofuscin granule has been captured it would proceed to be drawn into the core, where it would be digested by potent encapsulated enzymes or nanomechanically minced into a liquid state and subsequently purged from the outlet port."

"The desired result of this defuscin mediated digestion would be the fragmentation and ideally dissolution of the chemical crosslinks that provide lipofuscin its refractive properties. Other defuscin-class nanodevice designs may include proboscises that serve dual purposes; as potential electrodes for highly localized hyperthermic interventions, following insertion into the lipofuscin mass, or hollow nanosyringes… for the injection of powerful cleaving enzymes. The nanomechanical segmentation or disassembly of individual lipofuscin granules at atomic/molecular resolution may be possible employing arrays of diamondoid "debriders" to reduce lipofuscin to its most elemental and harmless fractions. Larger fragments could subsequently be encapsulated for egress through the urinary or gastrointestinal tracts.

The overarching premise here is that treated cells might be thus induced to a more robust state of health (perhaps functioning at more youthful levels) when this cellular burden is extricated."

Nanomedical Device and Systems Design: Challenges, Possibilities, Visions (November 22, 2013 by CRC Press)

This book endeavors to explore a significant range of conceptual nanomedical components, devices and systems, as well as to present some of the latest real world laboratory-based research, which may lead to the development of advanced and highly efficacious nanomedical technologies. This volume is trisegmented; the initial segment utilizes an envisaged conceptual exemplar nanodevice and system (Vascular Cartographic Scanning Nanodevice - VCSN), which the author has evolved, to explore various potential design considerations, which might enable specific functionalities of sophisticated autonomous nanomedical devices. The second segment is comprised of chapters that have been contributed by world class experts in the field, who present and articulate pioneering laboratory-based nanomedical research. The final segment investigates more highly conceptual nanomedical possibilities and visions relating to the implementation of advanced nanomedicine in remote regions and the developing world, as well as nanomedicine in space applications, human augmentation and longevity.

####

About Nanobotmodels
Our company Nanobotmodels was founded in 2007 and it goal is develop modern art-science-technology intersections. Nanotechnology boost medicine, engineering, biotechnology, electronics soon, so artwork and vision of the nanofuture will be very useful.

We are making hi-end nanotechnology and nanomedicine illustration and animation. You can imagine any interesting to you animation, illustration or presentation materials, and we can make real.

For more information, please click here

Contacts:
common questions: info(at)nanobotmodels.com
sales and image permissions: sales(at)nanobotmodels.com

Copyright © Nanobotmodels

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Transition from 3 to 2 dimensions increases conduction, MIPT scientists discover July 6th, 2015

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

BBC World Service to broadcast Forum discussion on graphene July 6th, 2015

Production of Zirconium Carbide Nanoparticles at Low Temperature without Thermal Operations July 5th, 2015

Possible Futures

BBC World Service to broadcast Forum discussion on graphene July 6th, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Harris & Harris Group Portfolio Company D-Wave Systems Announces 1,000 Qubit Processor and is Discussed in the Economist June 23rd, 2015

Global Nanoclays Market Analysis, Size, Growth, Trends And Segment Forecasts, 2015 To 2022: Grand View Research, Inc June 15th, 2015

Molecular Machines

Injectable electronics: New system holds promise for basic neuroscience, treatment of neuro-degenerative diseases June 8th, 2015

One step closer to a single-molecule device: Columbia Engineering researchers first to create a single-molecule diode -- the ultimate in miniaturization for electronic devices -- with potential for real-world applications May 25th, 2015

UCLA nanoscientists are first to model atomic structures of three bacterial nanomachines: Cryo electron microscope enables scientists to explore the frontiers of targeted antibiotics April 21st, 2015

Advances in molecular electronics: Lights on -- molecule on: Researchers from Dresden and Konstanz succeed in light-controlled molecule switching April 20th, 2015

Molecular Nanotechnology

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

$8.5M Grant For Developing Nano Printing Technology: 4-D printing to advance chemistry, materials sciences and defense capabilities June 18th, 2015

Injectable electronics: New system holds promise for basic neuroscience, treatment of neuro-degenerative diseases June 8th, 2015

One step closer to a single-molecule device: Columbia Engineering researchers first to create a single-molecule diode -- the ultimate in miniaturization for electronic devices -- with potential for real-world applications May 25th, 2015

Announcements

Transition from 3 to 2 dimensions increases conduction, MIPT scientists discover July 6th, 2015

A Stretchy Mesh Heater for Sore Muscles July 6th, 2015

BBC World Service to broadcast Forum discussion on graphene July 6th, 2015

Production of Zirconium Carbide Nanoparticles at Low Temperature without Thermal Operations July 5th, 2015

Life Extension/Cryonics

Indefinite Life Extension Activists Organize Online Demonstration February 26th, 2015

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

utsandiego.com November 22nd, 2012

Nanoparticles against aging October 3rd, 2012

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project