Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > VUB team develops breakthrough nanobody technology against liver inflammation

Abstract:
“During a previous research project financed by an ERC Starting Grant, my team discovered that a specific type of molecule, pannexins, played an important role in certain inflammatory diseases,” says Vinken. “Pannexins are tube-like molecules found in the cell membrane. In a healthy state, these tubes are closed, but when diseased, they open, allowing substances through, leading to inflammation and eventually cell death. By using nanobodies, the opening of these pannexin tubes is suppressed, interrupting the inflammatory reaction.”

VUB team develops breakthrough nanobody technology against liver inflammation

Brussels, Belgium | Posted on December 8th, 2023

Vinken received additional funding, an ERC Proof of Concept and an FWO research grant, to develop this nanobody technology. For this, he is working with Professor Nick Devoogdt and postdoc Timo De Groof from the Molecular Imaging and Therapy research group at VUB. Devoogdt and De Groof specialise in creating and visualising nanobodies.

“VUB has a long tradition of research into nanobodies,” says Devoogdt. “This tradition began with Professor Raymond Hamers. In 1989, with his wife, Cécile Casterman, and Serge Muyldermans, he discovered that camel blood contained a smaller sort of antibody. The discovery led to several spin-offs and various innovative therapeutic techniques. Through the work of Mathieu Vinken, we have discovered another promising research direction. Specifically, we have been able to show that nanobody technology works much better in the event of paracetamol overdose than the current remedy using acetylcysteine.”

“Nanobodies close pannexins with unprecedented efficiency,” says Vinken. Until now, research has been conducted in vitro and on a mouse model. In the next step, a clinical study will investigate possible side effects. The potential of pannexin-specific nanobodies to treat more complex disease states in combination with other agents will eventually be investigated. The findings were published on 11 October in the Journal of Nanobiotechnology. The team has also filed a patent application with a view to further (commercial) development of the technology and attracting investors or business partners for collaboration.

####

For more information, please click here

Contacts:
Sam Jaspers
Vrije Universiteit Brussel

Copyright © Vrije Universiteit Brussel

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Reference

Related News Press

News and information

Flexible electronics integrated with paper-thin structure for use in space January 17th, 2025

‘Brand new physics’ for next generation spintronics: Physicists discover a unique quantum behavior that offers a new way to manipulate electron-spin and magnetization to push forward cutting-edge spintronic technologies, like computing that mimics the human brain January 17th, 2025

Quantum engineers ‘squeeze’ laser frequency combs to make more sensitive gas sensors January 17th, 2025

How a milk component could eliminate one of the biggest challenges in treating cancer and other disease, including rare diseases: Nebraska startup to use nanoparticles found in milk to target therapeutics to specific cells January 17th, 2025

Possible Futures

Quantum engineers ‘squeeze’ laser frequency combs to make more sensitive gas sensors January 17th, 2025

How a milk component could eliminate one of the biggest challenges in treating cancer and other disease, including rare diseases: Nebraska startup to use nanoparticles found in milk to target therapeutics to specific cells January 17th, 2025

The National Space Society Congratulates SpaceX on Starship’s 7th Test Flight: Latest Test of the Megarocket Hoped to Demonstrate a Number of New Technologies and Systems January 17th, 2025

The National Space Society Congratulates Blue Origin on the Inaugural Flight of New Glenn: The Heavy Lift Reusable Rocket Will Open New Frontiers and Provide Healthy Competition January 17th, 2025

Nanomedicine

How a milk component could eliminate one of the biggest challenges in treating cancer and other disease, including rare diseases: Nebraska startup to use nanoparticles found in milk to target therapeutics to specific cells January 17th, 2025

Exosomes: A potential biomarker and therapeutic target in diabetic cardiomyopathy November 8th, 2024

NYU Abu Dhabi researchers develop novel covalent organic frameworks for precise cancer treatment delivery: NYU Abu Dhabi researchers develop novel covalent organic frameworks for precise cancer treatment delivery September 13th, 2024

Unveiling the power of hot carriers in plasmonic nanostructures August 16th, 2024

Discoveries

Autonomous AI assistant to build nanostructures: An interdisciplinary research group at TU Graz is working on constructing logic circuits through the targeted arrangement of individual molecules: Artificial intelligence should speed up the process enormously January 17th, 2025

‘Brand new physics’ for next generation spintronics: Physicists discover a unique quantum behavior that offers a new way to manipulate electron-spin and magnetization to push forward cutting-edge spintronic technologies, like computing that mimics the human brain January 17th, 2025

Quantum engineers ‘squeeze’ laser frequency combs to make more sensitive gas sensors January 17th, 2025

How a milk component could eliminate one of the biggest challenges in treating cancer and other disease, including rare diseases: Nebraska startup to use nanoparticles found in milk to target therapeutics to specific cells January 17th, 2025

Announcements

Quantum engineers ‘squeeze’ laser frequency combs to make more sensitive gas sensors January 17th, 2025

How a milk component could eliminate one of the biggest challenges in treating cancer and other disease, including rare diseases: Nebraska startup to use nanoparticles found in milk to target therapeutics to specific cells January 17th, 2025

The National Space Society Congratulates SpaceX on Starship’s 7th Test Flight: Latest Test of the Megarocket Hoped to Demonstrate a Number of New Technologies and Systems January 17th, 2025

The National Space Society Congratulates Blue Origin on the Inaugural Flight of New Glenn: The Heavy Lift Reusable Rocket Will Open New Frontiers and Provide Healthy Competition January 17th, 2025

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Autonomous AI assistant to build nanostructures: An interdisciplinary research group at TU Graz is working on constructing logic circuits through the targeted arrangement of individual molecules: Artificial intelligence should speed up the process enormously January 17th, 2025

Flexible electronics integrated with paper-thin structure for use in space January 17th, 2025

‘Brand new physics’ for next generation spintronics: Physicists discover a unique quantum behavior that offers a new way to manipulate electron-spin and magnetization to push forward cutting-edge spintronic technologies, like computing that mimics the human brain January 17th, 2025

Quantum engineers ‘squeeze’ laser frequency combs to make more sensitive gas sensors January 17th, 2025

Nanobiotechnology

How a milk component could eliminate one of the biggest challenges in treating cancer and other disease, including rare diseases: Nebraska startup to use nanoparticles found in milk to target therapeutics to specific cells January 17th, 2025

Exosomes: A potential biomarker and therapeutic target in diabetic cardiomyopathy November 8th, 2024

NYU Abu Dhabi researchers develop novel covalent organic frameworks for precise cancer treatment delivery: NYU Abu Dhabi researchers develop novel covalent organic frameworks for precise cancer treatment delivery September 13th, 2024

Nanobody inhibits metastasis of breast tumor cells to lung in mice: “In the present study we describe the development of an inhibitory nanobody directed against an extracellular epitope present in the native V-ATPase c subunit.” August 16th, 2024

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project