Home > Press > Immunomodulatory effect of nanoparticles
![]() |
Abstract:
Polymeric nanoparticles for immunotherapy represent a dynamic research field. The possibility to control their size, charge, and other surface properties provides the opportunity to affect both uptake by immune cells and induction of immunity. Dendritic cells (DC), which represent the most potent antigen-presenting cells of the immune system, are one of the main targets of current NP-based immunotherapeutic approaches against tumors.
Researcher from the Max Planck Institute for Polymer Research in Mainz, Germany, now study the uptake of unfunctionalized, sulfonate- and phosphonate-functionalized polystyrene NP by immature DC (iDC) and mature DC (mDC). iDC display a higher time- and dose-dependent uptake of functionalized polystyrene NP mDC. Notably, NP induce an enhanced maturation of iDC resulting in a significantly enhanced T cell stimulatory capacity.
Considering the increasing use of nanomaterials in clinical studies, investigations on the effect of nanomaterials on cell morphology and functionality are critical for screening materials that can potentially be used in clinical settings. The results are important for the research on immunomodulatory properties of NP and their potential applications in immunotherapy.
####
For more information, please click here
Copyright © Wiley-VCH Materials Science Journals
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Related Links |
Link to the original paper on Wiley Online Library:
Related News Press |
News and information
New organic molecule shatters phosphorescence efficiency records and paves way for rare metal-free applications July 5th, 2024
Single atoms show their true color July 5th, 2024
New method cracked for high-capacity, secure quantum communication July 5th, 2024
Searching for dark matter with the coldest quantum detectors in the world July 5th, 2024
Nanomedicine
The mechanism of a novel circular RNA circZFR that promotes colorectal cancer progression July 5th, 2024
Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024
Advances in priming B cell immunity against HIV pave the way to future HIV vaccines, shows quartet of new studies May 17th, 2024
Discoveries
Efficient and stable hybrid perovskite-organic light-emitting diodes with external quantum efficiency exceeding 40 per cent July 5th, 2024
A New Blue: Mysterious origin of the ribbontail ray’s electric blue spots revealed July 5th, 2024
New organic molecule shatters phosphorescence efficiency records and paves way for rare metal-free applications July 5th, 2024
Single atoms show their true color July 5th, 2024
Announcements
New organic molecule shatters phosphorescence efficiency records and paves way for rare metal-free applications July 5th, 2024
Single atoms show their true color July 5th, 2024
New method cracked for high-capacity, secure quantum communication July 5th, 2024
Searching for dark matter with the coldest quantum detectors in the world July 5th, 2024
![]() |
||
![]() |
||
The latest news from around the world, FREE | ||
![]() |
![]() |
||
Premium Products | ||
![]() |
||
Only the news you want to read!
Learn More |
||
![]() |
||
Full-service, expert consulting
Learn More |
||
![]() |