Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Carbon nanodots do an ultrafine job with in vitro lung tissue: New experiments highlight the role of charge and size when it comes to carbon nanodots that mimic the effect of nanoscale pollution particles on the human lung.

Dispersion behavior and agglomeration state of carbon nanodots and LSM images of co-cultures exposed to nanodots.

CREDIT
Estelle Durantie and Hana Barosova
Dispersion behavior and agglomeration state of carbon nanodots and LSM images of co-cultures exposed to nanodots. CREDIT Estelle Durantie and Hana Barosova

Abstract:
Epidemiological studies have established a strong correlation between inhaling ultrafine particles from incomplete combustion and respiratory and cardiovascular diseases. Still, relatively little is known about the mechanisms behind how air particulates affect human health. New work with carbon nanodots seeks to provide the first model of how ultrafine carbon-based particles interact with the lung tissues.

Carbon nanodots do an ultrafine job with in vitro lung tissue: New experiments highlight the role of charge and size when it comes to carbon nanodots that mimic the effect of nanoscale pollution particles on the human lung.

Washington, DC | Posted on September 12th, 2018

An international group of researchers created a 3D lung cell model system to investigate how carbon-based combustion byproducts behave as they interact with human epithelial tissue. In Biointerphases, an AVS journal from AIP Publishing, the investigators discovered that the surface properties of the carbon nanodot's properties and aggregation patterns affected their distribution in a lab-grown copy of the lung's barrier layer, the epithelium. The carbon nanodots served as representatives for air pollution particles.

"Localization and quantification of inhaled carbon nanoparticles at the cellular level has been very difficult," said Barbara Rothen-Rutishauser, an author on the paper, which is part of a special focus issue of the journal Biointerphases on Women in Biointerface Science. "We now have a model fluorescent particle that can try to answer questions about the fate of ultrafine particles in the lung."

At less than 100 nanometers in diameter, ultrafine particles have the small size and large relative surface area to wreak havoc on cells and potentially enter the bloodstream. Other groups' research has shown that ultrafine particles induce adverse effects on the lungs and cardiovascular system by increasing oxidative stress in the body.

Because of particle size, it is difficult for lab techniques to distinguish between carbon in pollutants from carbon in tissues. Therefore, little is known about surface charge and states of agglomeration, two key physical and chemical features that affect how carbon particles interact with living tissues.

To begin modeling ultrafine particles, Estelle Durantie, another author of the study, turned to fluorescent carbon nanodots doped with nitrogen and a combination of nitrogen and sulfur with different sizes and charges. The team then applied these nanodots to the top layer of a lab-grown epithelial tissue, where gas exchange typically happens in the lung.

Since regular fluorescent microscopes lack the resolution to visualize such small particles, the group used spectroscopy and UV light to detect and quantify nanodots as they migrated from the luminal compartment past their lung model's immune cells. As the researchers expected, charged particles tended to stick together before penetrating the gas-exchange barrier. While most of the neutrally charged nanodots passed through the tissue after only an hour, only 20 percent of the agglomerated charged particles infiltrated the epithelium.

Rothen-Rutishauser said she hopes to further improve nanodots so that they better mimic ultrafine particles. "What we're seeing is that translocation depends on aggregation state," Rothen-Rutishauser said. "We hope to continue trying out different sizes of nanodots, including other types of particles that get us closer to the real environment."

####

About American Institute of Physics
The AVS journal Biointerphases emphasizes quantitative characterization of biomaterials and biological interfaces. As an interdisciplinary journal, a strong foundation of chemistry, physics, biology, engineering, theory, and/or modelling is incorporated into originated articles, reviews, and opinionated essays.

For more information, please click here

Contacts:
Rhys Leahy

301-209-3090

Copyright © American Institute of Physics

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

The article, "Carbon nanodots: Opportunities and limitations to study their biodistribution at the human lung epithelial tissue barrier," is authored by Estelle Durantie, Hana Barosova, Barbara Drasler, Laura Rodriguez-Lorenzo, Dominic Urban, Dimitri Vanhecke, Dedy Septiadi, Liliane Ackermann-Hirschi, Alke Petri-Fink, and Barbara Rothen-Rutishauser. The article appears in Biointerphases Sept. 11, 2018 (DOI: 10.1116/1.5043373) and can be accessed at:

Related News Press

News and information

Arrowhead Pharmaceuticals Reports Inducement Grants under NASDAQ Marketplace Rule 5635(c)(4) June 22nd, 2019

Next-gen solar cells spin in new direction: Phosphorene shows efficiency promise June 21st, 2019

Researchers report new understanding of thermoelectric materials: Discovery leads to promising new materials for converting waste heat to power June 21st, 2019

Millions with neurological diseases could find new option in implantable neurostimulation devices June 21st, 2019

Imaging

New Video Highlights Specific Topics Sought in Call for Papers for the 2019 IEEE International Electron Devices Meeting (IEDM) June 13th, 2019

2D crystals conforming to 3D curves create strain for engineering quantum devices June 7th, 2019

New Argonne coating could have big implications for lithium batteries May 14th, 2019

Better microring sensors for optical applications May 10th, 2019

Nanotubes/Buckyballs/Fullerenes/Nanorods

Making graphene-based desalination membranes less prone to defects, better at separating June 13th, 2019

Shaking hands with human or robot? Nanotubes make them alike as never before June 6th, 2019

Generating high-quality single photons for quantum computing: New dual-cavity design emits more single photons that can carry quantum information at room temperature May 17th, 2019

Self-powered wearable tech May 8th, 2019

Nanomedicine

Arrowhead Pharmaceuticals Reports Inducement Grants under NASDAQ Marketplace Rule 5635(c)(4) June 22nd, 2019

'Nanoemulsion' gels offer new way to deliver drugs through the skin: Novel materials made with FDA-approved components could deliver large payloads of active ingredients June 21st, 2019

Millions with neurological diseases could find new option in implantable neurostimulation devices June 21st, 2019

Arrowhead Pharmaceuticals Receives Orphan Drug Designation for ARO-APOC3 June 21st, 2019

Discoveries

'Nanoemulsion' gels offer new way to deliver drugs through the skin: Novel materials made with FDA-approved components could deliver large payloads of active ingredients June 21st, 2019

Next-gen solar cells spin in new direction: Phosphorene shows efficiency promise June 21st, 2019

Ice lithography: opportunities and challenges in 3D nanofabrication June 21st, 2019

Researchers report new understanding of thermoelectric materials: Discovery leads to promising new materials for converting waste heat to power June 21st, 2019

Announcements

Arrowhead Pharmaceuticals Reports Inducement Grants under NASDAQ Marketplace Rule 5635(c)(4) June 22nd, 2019

Ice lithography: opportunities and challenges in 3D nanofabrication June 21st, 2019

Researchers report new understanding of thermoelectric materials: Discovery leads to promising new materials for converting waste heat to power June 21st, 2019

Millions with neurological diseases could find new option in implantable neurostimulation devices June 21st, 2019

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

'Nanoemulsion' gels offer new way to deliver drugs through the skin: Novel materials made with FDA-approved components could deliver large payloads of active ingredients June 21st, 2019

Next-gen solar cells spin in new direction: Phosphorene shows efficiency promise June 21st, 2019

Ice lithography: opportunities and challenges in 3D nanofabrication June 21st, 2019

Electron-behaving nanoparticles rock current understanding of matter: Discovery will lead to new methods for materials design June 20th, 2019

Tools

Millions with neurological diseases could find new option in implantable neurostimulation devices June 21st, 2019

University of Aberdeen use the Deben CT5000 to observe compressive damage mechanisms in syntactic foam June 14th, 2019

2D crystals conforming to 3D curves create strain for engineering quantum devices June 7th, 2019

nPoint piezo driven nanopositioning flexure stages now available from Elliot Scientific June 4th, 2019

Environment

Good vibrations: Using piezoelectricity to ensure hydrogen sensor sensitivity May 24th, 2019

New surface treatment could improve refrigeration efficiency: A slippery surface for liquids with very low surface tension promotes droplet formation, facilitating heat transfer May 17th, 2019

Better microring sensors for optical applications May 10th, 2019

Transforming waste heat into clean energy: Researchers use supercomputers to explore new materials for thermoelectric generation May 2nd, 2019

Safety-Nanoparticles/Risk management

Plastic waste disintegrates into nanoparticles, study finds December 28th, 2018

Spectradyne Partners with Particle Technology Labs for Measurement Services December 6th, 2018

Study provides insight into how nanoparticles interact with biological systems: Findings can help scientists engineer nanoparticles that are ‘benign by design’ October 18th, 2018

TUBALL single wall carbon nanotubes: No ecotoxicity found, unlike other carbon nanotubes October 12th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project