Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Guo Lab Shows Potential of RNA as Heat-resistant Polymer Material for Nanoarchitectures

Abstract:
A team of nanotechnology researchers at the University of Kentucky has discovered new methods to build heat resistant nanostructures and arrays using RNA.

Guo Lab Shows Potential of RNA as Heat-resistant Polymer Material for Nanoarchitectures

Lexington, KY | Posted on April 23rd, 2014

The research, led by Peixuan Guo, professor and William Farish Endowed Chair in Nanobiotechnology at the UK College of Pharmacy and Markey Cancer Center, is reported in an article titled "RNA as a Boiling-Resistant Anionic Polymer Material To Build Robust Structures with Defined Shape and Stoichiometry," coauthored by Emil F. Khisamutdinov and Daniel L. Jasinski.

The article, which will appear in a forthcoming edition of the journal ACS Nano, published by the American Chemical Society (ACS), was selected as an ACS "Editors' Choice" and prepublication data is available for free download as a PDF through open access at dx.doi.org/10.1021/nn5006254.

Chemical polymers have seen extensive use in a variety of industries including clothing, piping, plastics, containers, bottles, cookware, tools and medical materials for drug delivery and tissue engineer materials because of their high stability and ability to hold their global shape and size. However, on the microscopic scale, these polymers form into random micro-structures, making their size and shape difficult to control.

The Guo lab reports that RNA (ribonucleic acid) can be used as an anionic polymer material to build nanostructures with controllable shape and defined structure. The researchers have fabricated a new RNA triangle structure that utilizes RNA's intrinsic control over shape and size on the nano scale, while demonstrating strong stability.

Previously, RNA was seen as structurally fragile and easily dissociable at a range of temperatures from 35-70 degrees Celsius, making its application feasibility in an industrial setting very limited. Using the special RNA motif discovered in Guo's lab and a new methodology, the researchers demonstrated that they can build RNA nanostructures and patterned arrays that are resistant to 100 degrees Celsius, the boiling temperature of water.

The new RNA triangular nanoarchitechtures can be used to form arrays with a controllable repeat number of the scaffold, resembling monomer units in a polymerization reaction. Thus, the Guo lab was able to produce a honeycomb RNA structure with the new RNAs, allowing for the production of RNA sheets.

Experts say this breakthrough pushes the field of RNA nanotechnology forward, positioning RNA to be a new, unique type of polymer with advantages over conventional chemical polymers.

"This research shows great potential for building stable RNA nanoparticles with properties that could be more easily controlled than standard polymers," said Jessica Tucker, National Institute of Biomedical Imaging and Bioengineering program director for drug and gene delivery systems and devices. "The more control we have over the nanoparticles, the better we can tailor them for use in therapeutics for diseases ranging from cancer to diabetes."

The research was supported by National Institute of Biomedical Imaging and Bioengineering AND National Cancer Institute grants NIBIB EB003730 and NCI CA151648.

####

For more information, please click here

Contacts:
Keith Hautala

859-323-2396

Copyright © University of Kentucky

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download article:

Related News Press

News and information

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

Chemical interactions between silver nanoparticles and thiols: A comparison of mercaptohexanol again September 30th, 2014

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

Nanoparticles Used to Improve Quality of Bone Cement September 29th, 2014

'Pixel' engineered electronics have growth potential: Rice, Oak Ridge, Vanderbilt, Penn scientists lead creation of atom-scale semiconducting composites September 29th, 2014

Imaging

Iranian Scientists Determine Grain Size, Minimize Time of Nanocomposite Synthesis September 29th, 2014

Oxford Instruments launches 3rd annual Indian nanotechnology seminars in Kolkata and Delhi - sharing expertise with Nanotechnology researchers in India September 25th, 2014

Govt.-Legislation/Regulation/Funding/Policy

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

How things coil: Researchers discover that simulation technology designed for Hollywood can be used as a predictive tool for understanding fundamental engineering problems September 29th, 2014

UT Arlington researchers develop transparent nanoscintillators for radiation detection for medical safety and homeland security September 29th, 2014

'Pixel' engineered electronics have growth potential: Rice, Oak Ridge, Vanderbilt, Penn scientists lead creation of atom-scale semiconducting composites September 29th, 2014

Molecular Nanotechnology

Penn Team Studies Nanocrystals by Passing Them Through Tiny Pores September 26th, 2014

Nanoscale assembly line August 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster: University of Leicester research team unlocks insights into creation of new nano-materials July 25th, 2014

Discoveries

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

Chemical interactions between silver nanoparticles and thiols: A comparison of mercaptohexanol again September 30th, 2014

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

Nanoparticles Used to Improve Quality of Bone Cement September 29th, 2014

Materials/Metamaterials

How things coil: Researchers discover that simulation technology designed for Hollywood can be used as a predictive tool for understanding fundamental engineering problems September 29th, 2014

Iranian Scientists Determine Grain Size, Minimize Time of Nanocomposite Synthesis September 29th, 2014

Nanoparticles Used to Improve Quality of Bone Cement September 29th, 2014

Production of Anticorrosive Chromate Nanocoatings in Iran September 27th, 2014

Announcements

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

Chemical interactions between silver nanoparticles and thiols: A comparison of mercaptohexanol again September 30th, 2014

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

Nanoparticles Used to Improve Quality of Bone Cement September 29th, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

New Topical Hemostatic Agent: Neutral Self-Assembling Peptide Hydrogel September 30th, 2014

Chemical interactions between silver nanoparticles and thiols: A comparison of mercaptohexanol again September 30th, 2014

A Heartbeat Away? Hybrid "Patch" Could Replace Transplants: TAU researcher harnesses gold nanoparticles to engineer novel biocompatible cardiac patch September 30th, 2014

Nanoparticles Used to Improve Quality of Bone Cement September 29th, 2014

Nanobiotechnology

How things coil: Researchers discover that simulation technology designed for Hollywood can be used as a predictive tool for understanding fundamental engineering problems September 29th, 2014

Penn Team Studies Nanocrystals by Passing Them Through Tiny Pores September 26th, 2014

Graphene and Amaranthus Superparamagnets: Breakthrough nanoparticles discovery of Indian researcher September 23rd, 2014

New NIH/DOE Grant for Life Science Studies at NSLS-II: Funding will support operation of three powerful experimental stations designed to reveal detailed structures of proteins, viruses, and more September 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE