Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Guo Lab Shows Potential of RNA as Heat-resistant Polymer Material for Nanoarchitectures

Abstract:
A team of nanotechnology researchers at the University of Kentucky has discovered new methods to build heat resistant nanostructures and arrays using RNA.

Guo Lab Shows Potential of RNA as Heat-resistant Polymer Material for Nanoarchitectures

Lexington, KY | Posted on April 23rd, 2014

The research, led by Peixuan Guo, professor and William Farish Endowed Chair in Nanobiotechnology at the UK College of Pharmacy and Markey Cancer Center, is reported in an article titled "RNA as a Boiling-Resistant Anionic Polymer Material To Build Robust Structures with Defined Shape and Stoichiometry," coauthored by Emil F. Khisamutdinov and Daniel L. Jasinski.

The article, which will appear in a forthcoming edition of the journal ACS Nano, published by the American Chemical Society (ACS), was selected as an ACS "Editors' Choice" and prepublication data is available for free download as a PDF through open access at dx.doi.org/10.1021/nn5006254.

Chemical polymers have seen extensive use in a variety of industries — including clothing, piping, plastics, containers, bottles, cookware, tools and medical materials for drug delivery and tissue engineer materials — because of their high stability and ability to hold their global shape and size. However, on the microscopic scale, these polymers form into random micro-structures, making their size and shape difficult to control.

The Guo lab reports that RNA (ribonucleic acid) can be used as an anionic polymer material to build nanostructures with controllable shape and defined structure. The researchers have fabricated a new RNA triangle structure that utilizes RNA's intrinsic control over shape and size on the nano scale, while demonstrating strong stability.

Previously, RNA was seen as structurally fragile and easily dissociable at a range of temperatures from 35-70 degrees Celsius, making its application feasibility in an industrial setting very limited. Using the special RNA motif discovered in Guo's lab and a new methodology, the researchers demonstrated that they can build RNA nanostructures and patterned arrays that are resistant to 100 degrees Celsius, the boiling temperature of water.

The new RNA triangular nanoarchitechtures can be used to form arrays with a controllable repeat number of the scaffold, resembling monomer units in a polymerization reaction. Thus, the Guo lab was able to produce a honeycomb RNA structure with the new RNAs, allowing for the production of RNA sheets.

Experts say this breakthrough pushes the field of RNA nanotechnology forward, positioning RNA to be a new, unique type of polymer with advantages over conventional chemical polymers.

"This research shows great potential for building stable RNA nanoparticles with properties that could be more easily controlled than standard polymers," said Jessica Tucker, National Institute of Biomedical Imaging and Bioengineering program director for drug and gene delivery systems and devices. "The more control we have over the nanoparticles, the better we can tailor them for use in therapeutics for diseases ranging from cancer to diabetes."

The research was supported by National Institute of Biomedical Imaging and Bioengineering AND National Cancer Institute grants NIBIB EB003730 and NCI CA151648.

####

For more information, please click here

Contacts:
Keith Hautala

859-323-2396

Copyright © University of Kentucky

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Download article:

Related News Press

News and information

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

Nanospiked bacteria are the brightest hard X-ray emitters July 2nd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Producing spin-entangled electrons July 2nd, 2015

Imaging

NIST ‘How-To’ Website Documents Procedures for Nano-EHS Research and Testing July 1st, 2015

Ultra-stable JILA microscopy technique tracks tiny objects for hours July 1st, 2015

Bruker Introduces Second-Generation Inspire Nanochemical Imaging Solution: Featuring Unique PeakForce IR and IR EasyAlign Technology July 1st, 2015

Carnegie Mellon chemists characterize 3-D macroporous hydrogels: Methods will allow researchers to develop new 'smart' materials June 30th, 2015

Govt.-Legislation/Regulation/Funding/Policy

New technology using silver may hold key to electronics advances July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

NIST ‘How-To’ Website Documents Procedures for Nano-EHS Research and Testing July 1st, 2015

Ultra-stable JILA microscopy technique tracks tiny objects for hours July 1st, 2015

Molecular Nanotechnology

$8.5M Grant For Developing Nano Printing Technology: 4-D printing to advance chemistry, materials sciences and defense capabilities June 18th, 2015

Injectable electronics: New system holds promise for basic neuroscience, treatment of neuro-degenerative diseases June 8th, 2015

One step closer to a single-molecule device: Columbia Engineering researchers first to create a single-molecule diode -- the ultimate in miniaturization for electronic devices -- with potential for real-world applications May 25th, 2015

Nature inspires first artificial molecular pump: Simple design mimics pumping mechanism of life-sustaining proteins found in living cells May 19th, 2015

Discoveries

Freezing single atoms to absolute zero with microwaves brings quantum technology closer: Atoms frozen to absolute zero using microwaves July 2nd, 2015

New technology using silver may hold key to electronics advances July 2nd, 2015

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

Nanospiked bacteria are the brightest hard X-ray emitters July 2nd, 2015

Materials/Metamaterials

New technology using silver may hold key to electronics advances July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Proposed TSCA Nanomaterial Rule ‘Premature’, Says Former EPA Toxicologist July 1st, 2015

NEI Announces the Issuance of Multiple Patents on Self-Healing & Superhydrophobic Coatings June 30th, 2015

Announcements

Nanospiked bacteria are the brightest hard X-ray emitters July 2nd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Producing spin-entangled electrons July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

New micro-supercapacitor structure inspired by the intricate design of leaves: A team of scientists in Korea has devised a new method for making a graphene film for supercapacitors July 2nd, 2015

The quantum middle man July 2nd, 2015

Freezing single atoms to absolute zero with microwaves brings quantum technology closer: Atoms frozen to absolute zero using microwaves July 2nd, 2015

New technology using silver may hold key to electronics advances July 2nd, 2015

Nanobiotechnology

Engineering the world’s smallest nanocrystal July 2nd, 2015

Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015

Newly-Developed Biosensor in Iran Detects Cocaine Addiction June 23rd, 2015

Researchers first to show that Saharan silver ants can control electromagnetic waves over an extremely broad range of the electromagnetic spectrum—findings may lead to biologically inspired coatings for passive radiative cooling of objects June 19th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project