Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > UCSB researchers discover living nanoscale 'necklace'

Abstract:
Researchers in physics and biology have made a discovery that could be instrumental in the production of miniaturized materials with many applications.

UC Santa Barbara researchers discover living nanoscale 'necklace'

Santa Barbara, CA – November 08, 2004

In an interdisciplinary endeavor at the University of California, Santa Barbara, a team of researchers in physics and biology have made a discovery at the nanoscale level that could be instrumental in the production of miniaturized materials with many applications. Dubbed a "living necklace," the finding was completely unexpected.

This discovery could influence the development of vehicles for chemical, drug, and gene delivery, enzyme encapsulation systems and biosensors, circuitry components, as well as templates for nanosized wires and optical materials. The findings are reported in the November 16 issue of the Proceedings of the National Academy of Sciences and published online the week of November 8.

The collaborating labs are those of Cyrus Safinya, professor of materials and physics and faculty member of the Biomolecular Science & Engineering Program, and Leslie Wilson, professor of biochemistry in the Department of Molecular, Cellular and Developmental Biology. The first author of the paper is Safinya's graduate student Daniel Needleman. Postdoctoral researchers Uri Raviv and Miguel Ojeda-Lopez from Safinya's group and Herbert Miller, a researcher in Wilson's group, completed the team.

UCSB - Schematics of higher-order assembly of nanometer-scale microtubules.
Schematics of higher-order assembly of nanometer-scale microtubules. Courtesy and Copyright © UCSB. Click to emlarge.

The scientists studied microtubules from the brain tissue of a cow to understand the mechanisms leading to their assembly and shape. Microtubules are nanometer-scale hollow cylinders derived from cell cytoskeleton. In an organism, microtubules and their assembled structures are critical components in a broad range of cell functions -- from providing tracks for the transport of cargo to forming the spindle structure in cell division. Their functions include the transport of neurotransmitters in neurons. The mechanism of their assembly within an organism has been poorly understood.

In the paper, the researchers report the discovery of a new type of higher order assembly of microtubules. Positively-charged large, linear molecules (tri-, tetra- and penta-valent cations) resulted in a tightly bundled hexagonal grouping of microtubules – a result that was predicted. But unexpectedly, the scientists found that small, spherical divalent cations caused the microtubules to assemble into a "necklace." They discovered distinct linear, branched and loop shaped necklaces.

Safinya and Needleman commented that from a formal theoretical physics perspective, the living necklace phase is the first experimental realization of a new type of membrane where the long microtubule molecules are oriented in the same direction but can diffuse within the living membrane.

They explained that the living necklace bundle is highly dynamic and that thermal fluctuations will cause it to change shape.

The scientists envision applications based on both the tight bundle and living necklace phases. For example, metallization of necklace bundles with different sizes and shapes would yield nanomaterials with controlled optical properties.

A more original application is in the area of using the assemblies – encased by a lipid bilayer – as drug or gene carriers where each nanotube may contain a distinct chemical, as noted by the team. In delivery applications the shape of the bundle determines its property. For example, the linear necklace phase with its higher surface to volume ratio would have a larger contact area and a faster delivery rate compared to the tight bundle phase.

The work was performed using state-of-the-art synchrotron x-ray scattering techniques at the Stanford Synchrotron Radiation Laboratory combined with sophisticated electron and optical microscopy at UCSB.


Cyrus Safinya can be reached by e-mail at safinya@mrl.ucsb.edu

Daniel Needleman can be reached at 805-893-7922 or by e-mail at needle@mrl.ucsb.edu

Contact:

Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220

Copyright © UCSB

If you have a comment, please us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Department of Molecular, Cellular and Developmental Biology

Related News Press

Possible Futures

Chemical cages: New technique advances synthetic biology February 10th, 2016

New thin film transistor may lead to flexible devices: Researchers engineer an electronics first, opening door to flexible electronics February 10th, 2016

Electron's 1-D metallic surface state observed: A step for the prediction of electronic properties of extremely-fine metal nanowires in next-generation semiconductors February 9th, 2016

Scientists create laser-activated superconductor February 8th, 2016

Molecular Machines

'Spermbots' could help women trying to conceive (video) January 15th, 2016

Scientists blueprint tiny cellular 'nanomachine' December 17th, 2015

Nano-walkers take speedy leap forward with first rolling DNA-based motor: Fastest DNA motor holds potential for disease diagnostics December 1st, 2015

Rice makes light-driven nanosubmarines: Speedy single-molecule submersibles are a first November 16th, 2015

Nanomedicine

Nanoparticle therapy that uses LDL and fish oil kills liver cancer cells February 9th, 2016

Leading bugs to the death chamber: A kinder face of cholesterol February 8th, 2016

UTHealth research looks at nanotechnology to help prevent preterm birth February 7th, 2016

Scientists take key step toward custom-made nanoscale chemical factories: Berkeley Lab researchers part of team that creates new function in tiny protein shell structures February 6th, 2016

Sensors

Scientists have put a high precision blood assay into a simple test strip: Researchers have developed a new biosensor test system based on magnetic nanoparticles February 3rd, 2016

Nanosheet growth technique could revolutionize nanomaterial production February 1st, 2016

New record in nanoelectronics at ultralow temperatures January 28th, 2016

NBC LEARN DEBUTS SIX-PART VIDEO SERIES, “NANOTECHNOLOGY: SUPER SMALL SCIENCE” Produced by NBC Learn in partnership with the National Science Foundation, and narrated by NBC News/MSNBC’s Kate Snow, series highlights leading research in nanotechnology January 25th, 2016

Nanoelectronics

Electron's 1-D metallic surface state observed: A step for the prediction of electronic properties of extremely-fine metal nanowires in next-generation semiconductors February 9th, 2016

The iron stepping stones to better wearable tech without semiconductors February 8th, 2016

Spin dynamics in an atomically thin semi-conductor February 1st, 2016

New type of nanowires, built with natural gas heating: UNIST research team developed a new simple nanowire manufacturing technique February 1st, 2016

Discoveries

Chemical cages: New technique advances synthetic biology February 10th, 2016

New thin film transistor may lead to flexible devices: Researchers engineer an electronics first, opening door to flexible electronics February 10th, 2016

Making sense of metallic glass February 9th, 2016

Electron's 1-D metallic surface state observed: A step for the prediction of electronic properties of extremely-fine metal nanowires in next-generation semiconductors February 9th, 2016

Announcements

Chemical cages: New technique advances synthetic biology February 10th, 2016

New thin film transistor may lead to flexible devices: Researchers engineer an electronics first, opening door to flexible electronics February 10th, 2016

Superconductivity: Footballs with no resistance - Indications of light-induced lossless electricity transmission in fullerenes contribute to the search for superconducting materials for practical applications February 9th, 2016

SUNY Poly and GLOBALFOUNDRIES Announce New $500M R&D Program in Albany To Accelerate Next Generation Chip Technology: Arrival of Second Cutting Edge EUV Lithography Tool Launches New Patterning Center That Will Generate Over 100 New High Tech Jobs at SUNY Poly February 9th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic