Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > UCSB researchers discover living nanoscale 'necklace'

Abstract:
Researchers in physics and biology have made a discovery that could be instrumental in the production of miniaturized materials with many applications.

UC Santa Barbara researchers discover living nanoscale 'necklace'

Santa Barbara, CA – November 08, 2004

In an interdisciplinary endeavor at the University of California, Santa Barbara, a team of researchers in physics and biology have made a discovery at the nanoscale level that could be instrumental in the production of miniaturized materials with many applications. Dubbed a "living necklace," the finding was completely unexpected.

This discovery could influence the development of vehicles for chemical, drug, and gene delivery, enzyme encapsulation systems and biosensors, circuitry components, as well as templates for nanosized wires and optical materials. The findings are reported in the November 16 issue of the Proceedings of the National Academy of Sciences and published online the week of November 8.

The collaborating labs are those of Cyrus Safinya, professor of materials and physics and faculty member of the Biomolecular Science & Engineering Program, and Leslie Wilson, professor of biochemistry in the Department of Molecular, Cellular and Developmental Biology. The first author of the paper is Safinya's graduate student Daniel Needleman. Postdoctoral researchers Uri Raviv and Miguel Ojeda-Lopez from Safinya's group and Herbert Miller, a researcher in Wilson's group, completed the team.

UCSB - Schematics of higher-order assembly of nanometer-scale microtubules.
Schematics of higher-order assembly of nanometer-scale microtubules. Courtesy and Copyright © UCSB. Click to emlarge.

The scientists studied microtubules from the brain tissue of a cow to understand the mechanisms leading to their assembly and shape. Microtubules are nanometer-scale hollow cylinders derived from cell cytoskeleton. In an organism, microtubules and their assembled structures are critical components in a broad range of cell functions -- from providing tracks for the transport of cargo to forming the spindle structure in cell division. Their functions include the transport of neurotransmitters in neurons. The mechanism of their assembly within an organism has been poorly understood.

In the paper, the researchers report the discovery of a new type of higher order assembly of microtubules. Positively-charged large, linear molecules (tri-, tetra- and penta-valent cations) resulted in a tightly bundled hexagonal grouping of microtubules – a result that was predicted. But unexpectedly, the scientists found that small, spherical divalent cations caused the microtubules to assemble into a "necklace." They discovered distinct linear, branched and loop shaped necklaces.

Safinya and Needleman commented that from a formal theoretical physics perspective, the living necklace phase is the first experimental realization of a new type of membrane where the long microtubule molecules are oriented in the same direction but can diffuse within the living membrane.

They explained that the living necklace bundle is highly dynamic and that thermal fluctuations will cause it to change shape.

The scientists envision applications based on both the tight bundle and living necklace phases. For example, metallization of necklace bundles with different sizes and shapes would yield nanomaterials with controlled optical properties.

A more original application is in the area of using the assemblies – encased by a lipid bilayer – as drug or gene carriers where each nanotube may contain a distinct chemical, as noted by the team. In delivery applications the shape of the bundle determines its property. For example, the linear necklace phase with its higher surface to volume ratio would have a larger contact area and a faster delivery rate compared to the tight bundle phase.

The work was performed using state-of-the-art synchrotron x-ray scattering techniques at the Stanford Synchrotron Radiation Laboratory combined with sophisticated electron and optical microscopy at UCSB.


Cyrus Safinya can be reached by e-mail at safinya@mrl.ucsb.edu

Daniel Needleman can be reached at 805-893-7922 or by e-mail at needle@mrl.ucsb.edu

Contact:

Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220

Copyright © UCSB

If you have a comment, please us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Department of Molecular, Cellular and Developmental Biology

Related News Press

Possible Futures

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Superconducting circuits, simplified: New circuit design could unlock the power of experimental superconducting computer chips October 18th, 2014

Nanocoatings Market By Product Is Expected To Reach USD 8.17 Billion By 2020: Grand View Research, Inc. October 15th, 2014

Perpetuus Carbon Group Receives Independent Verification of its Production Capacity for Graphenes at 140 Tonnes per Annum: Perpetuus Becomes the First Manufacturer in the Sector to Allow Third Party Audit October 7th, 2014

Molecular Machines

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster: University of Leicester research team unlocks insights into creation of new nano-materials July 25th, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Nanomedicine

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Sensors

MEMS & Sensors Technology Showcase: Finalists Announced for MEMS Executive Congress US 2014 October 23rd, 2014

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Graphenea opens US branch October 16th, 2014

Nanoelectronics

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Materials for the next generation of electronics and photovoltaics: MacArthur Fellow develops new uses for carbon nanotubes October 21st, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Discoveries

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Announcements

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Advancing thin film research with nanostructured AZO: Innovnano’s unique and cost-effective AZO sputtering targets for the production of transparent conducting oxides October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE