Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > 3-D Nanostructures Capture Rare Tumor Cells in Blood

Abstract:
Perhaps the earliest sign that cancer is starting to spread is the appearance of so-called circulating tumor cells, or CTCs, in the blood stream. These are the forward army of a metastatic tumor, the cells that escape from the primary tumor and colonize other organs in the body. Having a fast, inexpensive method for capturing these rare cells from human blood could provide valuable information that would likely improve therapy, but current CTC assays are not quite up to this task.

3-D Nanostructures Capture Rare Tumor Cells in Blood

Bethesda, MD | Posted on November 18th, 2009

That situation may soon change. In a report published in the journal Angewandte Chemie International Edition, a research team at the California Institute of Technology's NanoSystems Biology Cancer Center, led by Hsian-Rong Tseng, Ph.D., describes a device made of millions of nanoscale silicon pillars that gently captured over 40% of the CTCs added to samples of human blood. The capture process takes a mere 45 minutes and leaves up to 90% of the trapped cells alive for further analysis.

Tseng and his colleagues prepared their device using the standard lithographic tools developed for making computer chips. After creating a forest of nanopillars on a silicon wafer, the investigators then coat the surface of the pillars with an antibody that recognizes a molecule on the surface of CTCs known as EpCAM, or epithelial-cell adhesion molecule. EpCAM plays a role in helping CTCs stick to the lining of blood vessels, enabling these metastatic cells to escape the blood stream and eventually colonize organs such as the liver and bone. When CTCs are applied to the device, they respond to the presence of the EpCAM antibody by sending out hair-like projections that appear to interact strongly with the silicon nanopillars and enhance the CTC capture efficiency. In contrast, CTCs captured on a flat silicon structure do not produce these projections.

This work, which is detailed in a paper titled, "Three-Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells," was supported by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. Investigators from MagArray Inc., also participated in this study. An abstract of this paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Gene therapy relieves back pain, repairs damaged disc in mice: Study suggests nanocarriers loaded with DNA could replace opioids May 17th, 2024

Shedding light on perovskite hydrides using a new deposition technique: Researchers develop a methodology to grow single-crystal perovskite hydrides, enabling accurate hydride conductivity measurements May 17th, 2024

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in cuprate superconductor May 17th, 2024

Possible Futures

Advances in priming B cell immunity against HIV pave the way to future HIV vaccines, shows quartet of new studies May 17th, 2024

International research team uses wavefunction matching to solve quantum many-body problems: New approach makes calculations with realistic interactions possible May 17th, 2024

Aston University researcher receives £1 million grant to revolutionize miniature optical devices May 17th, 2024

Gene therapy relieves back pain, repairs damaged disc in mice: Study suggests nanocarriers loaded with DNA could replace opioids May 17th, 2024

Nanomedicine

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Advances in priming B cell immunity against HIV pave the way to future HIV vaccines, shows quartet of new studies May 17th, 2024

New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024

Announcements

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Finding quantum order in chaos May 17th, 2024

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in cuprate superconductor May 17th, 2024

Nanobiotechnology

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Advances in priming B cell immunity against HIV pave the way to future HIV vaccines, shows quartet of new studies May 17th, 2024

New micromaterial releases nanoparticles that selectively destroy cancer cells April 5th, 2024

Good as gold - improving infectious disease testing with gold nanoparticles April 5th, 2024

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project