Home > Nanotechnology Columns > Bergeson & Campbell, P.C. > Particle and Fibre Toxicology Publishes Results of MWCNT Inhalation Study in Mice
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Lynn L. Bergeson Managing Director Bergeson & Campbell, P.C. |
Abstract:
On August 9, 2013, Particle and Fibre Toxicology published a study entitled "Extrapulmonary transport of MWCNT following inhalation exposure."
August 16th, 2013
Particle and Fibre Toxicology Publishes Results of MWCNT Inhalation Study in Mice
On August 9, 2013, Particle and Fibre Toxicology published a study entitled "Extrapulmonary transport of MWCNT following inhalation exposure." See http://www.particleandfibretoxicology.com/content/10/1/38 The authors report that inhalation exposure studies of mice were conducted to determine if multi-walled carbon nanotubes (MWCNT) distribute to the tracheobronchial lymphatics, parietal pleura, respiratory musculature, and/or extrapulmonary organs. The study states that tracheobronchial lymph nodes were found to contain 1.08 and 7.34 percent of the lung burden at 1 day and 336 days post-exposure, respectively. On average, according to the study, there were 15,371 and 109,885 fibers per gram in liver, kidney, heart, and brain at 1 day and 336 days post-exposure, respectively. The burden of singlet MWCNT in the lymph nodes, diaphragm, chest wall, and extrapulmonary organs at 336 days post-exposure was significantly higher than at 1 day post-exposure. The abstract offers the following conclusions: "Inhaled MWCNT, which deposit in the lungs, are transported to the parietal pleura, the respiratory musculature, liver, kidney, heart and brain in a singlet form and accumulate with time following exposure. The tracheobronchial lymph nodes contain high levels of MWCNT following exposure and further accumulate over nearly a year to levels that are a significant fraction of the lung burden 1 day post-exposure." Although the authors are affiliated with the National Institute for Occupational Safety and Health (NIOSH), the study includes a disclaimer that the findings and conclusions in the study are those of the authors and do not necessarily represent the views of NIOSH.
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