Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > The brighter side of twisted polymers: Conjugated polymers designed with a twist produce tiny, brightly fluorescent particles with broad applications

This is fluorescence of the conjugated polymers in solution.
CREDIT
© 2017 Hubert Piwonski
This is fluorescence of the conjugated polymers in solution. CREDIT © 2017 Hubert Piwonski

Abstract:
A strategy to produce highly fluorescent nanoparticles through careful molecular design of conjugated polymers has been developed by KAUST researchers. Such tiny polymer-based particles could offer alternatives to conventional organic dyes and inorganic semiconductor quantum dots as fluorescent tags for medical imaging.

The brighter side of twisted polymers: Conjugated polymers designed with a twist produce tiny, brightly fluorescent particles with broad applications

Thuwal, Saudi Arabia | Posted on May 16th, 2017

Conjugated polymer-derived nanoparticles, called Pdots, are expected to transform several areas, including optoelectronics, bio-imaging, bio-sensing and nanomedicine, due to their intense fluorescence, high stability under exposure to light and low cytotoxicity. Their spectroscopic properties are tunable by tweaking the polymer structures. This makes it essential to consider their design at the molecular level.

Bio-imaging applications require nanoparticles small enough to be eliminated from the body and strongly emit light in the far-red to near-infrared range. However, current design and fabrication of Pdots have mostly relied on empirical approaches, hindering attempts to manufacture these ultrasmall nanoparticles.

To meet this challenge, Dr. Hubert Piwoski and Associate Professor Satoshi Habuchi came up with a systematic method that enhances the performance of Pdots. Habuchi explained that his team aimed to create Pdots of a smaller size and brighter fluorescence by using conjugated polymers, whose backbone of alternating single and multiple bonds enables so-called π electrons to move freely throughout the structure.

For the first time, the researchers opted for twisted, instead of planar, conjugated polymers as building blocks to generate their Pdots. Existing Pdots usually exhibit lower fluorescence intensity than their precursors as result of complex inter- and intra-chain photophysical interactions within particles.

According to Habuchi, this trial was a shot in the dark -- his team initiated the project without really knowing what would eventuate -- but they were still surprised by the fluorescence behaviors of these Pdots compared to their previously investigated analogues.

Preliminary results suggest that the newly synthesized nanoparticles were the smallest and brightest Pdots reported to date. "Therefore, we hypothesized that the twisted shape of the molecules is responsible for the very bright fluorescence due to the suppression of π-π interactions inside the particles," explained Habuchi.

The researchers validated their hypothesis by comprehensive photophysical and structural characterizations. "That was the most exciting moment of our project," added Habuchi, noting that this demonstration has opened a new door for the correct prediction of the fluorescence properties of Pdots.

"We are now trying to introduce functional groups into these Pdots for bioconjugation," Habuchi continued. The team is also designing and fabricating near-infrared-emitting nanoparticles.

####

For more information, please click here

Contacts:
Michelle D'Antoni

Copyright © King Abdullah University of Science and Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

RELATED JOURNAL ARTICLE:

Related News Press

News and information

Silk could improve sensitivity, flexibility of wearable body sensors August 20th, 2017

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Imaging

Industry’s First Dedicated Cryo-DualBeam System Automates Preparation of Frozen, Biological Samples: New Thermo Scientific Aquilos FIB/SEM protects sample integrity and enhances productivity for cryo-electron tomography workflow August 8th, 2017

Thermo Fisher Scientific Advances Cryo-EM Leadership to Drive Structural Biology Discoveries: New Thermo Scientific Krios G3i raises bar for performance, automation and time-to-results Breakthrough Thermo Scientific Glacios provides a cryo-EM entry path for a broader range of res August 8th, 2017

New Quattro Field Emission ESEM Emphasizes Versatility and Ease of Use: Thermo Scientific Quattro ESEM allows materials science researchers to study nanoscale structure in almost any material under a range of environmental conditions August 8th, 2017

Thermo Fisher Scientific’s New Talos F200i S/TEM Delivers Flexible, High-Performance Imaging: New compact S/TEM can be configured to meet specific imaging and analytical requirements for materials characterization in research laboratories August 8th, 2017

Possible Futures

Silk could improve sensitivity, flexibility of wearable body sensors August 20th, 2017

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Nanomedicine

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Freeze-dried foam soaks up carbon dioxide: Rice University scientists lead effort to make novel 3-D material August 16th, 2017

Gold shines through properties of nano biosensors: Researchers discover that fluorescence in ligand-protected gold nanoclusters is an intrinsic property of the gold particles themselves August 16th, 2017

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

Discoveries

Silk could improve sensitivity, flexibility of wearable body sensors August 20th, 2017

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Announcements

Silk could improve sensitivity, flexibility of wearable body sensors August 20th, 2017

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Silk could improve sensitivity, flexibility of wearable body sensors August 20th, 2017

The power of perovskite: OIST researchers improve perovskite-based technology in the entire energy cycle, from solar cells harnessing power to LED diodes to light the screens of future electronic devices and other lighting applications August 18th, 2017

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Researchers printed graphene-like materials with inkjet August 17th, 2017

Tools

Scientists from the University of Manchester and Diamond Light Source work with Deben to develop and test a new compression stage to study irradiated graphite at elevated temperatures August 15th, 2017

FRITSCH • Milling and Sizing! Innovations at POWTECH 2017 - Hall 2 • Stand 227 August 9th, 2017

Thermo Fisher Scientific Advances Cryo-EM Leadership to Drive Structural Biology Discoveries: New Thermo Scientific Krios G3i raises bar for performance, automation and time-to-results Breakthrough Thermo Scientific Glacios provides a cryo-EM entry path for a broader range of res August 8th, 2017

New Quattro Field Emission ESEM Emphasizes Versatility and Ease of Use: Thermo Scientific Quattro ESEM allows materials science researchers to study nanoscale structure in almost any material under a range of environmental conditions August 8th, 2017

Quantum Dots/Rods

New approach on research and design for CQD catalysts in World Scientific NANO August 2nd, 2017

Coupling a nano-trumpet with a quantum dot enables precise position determination July 14th, 2017

Graphene and quantum dots put in motion a CMOS-integrated camera that can see the invisible May 29th, 2017

Nanoparticles open new window for biological imaging: “Quantum dots” that emit infrared light enable highly detailed images of internal body structures April 10th, 2017

Nanobiotechnology

Gold nanostars and immunotherapy vaccinate mice against cancer: New treatment cures, vaccinates mouse in small proof-of-concept study August 18th, 2017

Freeze-dried foam soaks up carbon dioxide: Rice University scientists lead effort to make novel 3-D material August 16th, 2017

Gold shines through properties of nano biosensors: Researchers discover that fluorescence in ligand-protected gold nanoclusters is an intrinsic property of the gold particles themselves August 16th, 2017

Two Scientists Receive Grants to Develop New Materials: Chad Mirkin and Monica Olvera de la Cruz recognized by Sherman Fairchild Foundation August 16th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project