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Home > Press > Rice University's nanosubs gain better fluorescent properties for tracking

Rice University scientists have created light-driven, single-molecule submersibles. A new version of the molecule strengthens its fluorescent response for better tracking. Atoms in red make up the light-activated motor.
CREDIT: Tour Group/Rice University
Rice University scientists have created light-driven, single-molecule submersibles. A new version of the molecule strengthens its fluorescent response for better tracking. Atoms in red make up the light-activated motor.

CREDIT: Tour Group/Rice University

Abstract:
The next generation of nanosubmarines being developed at Rice University has been upgraded with tags that fluoresce longer, which enables the submersibles to be tracked for greater periods while being driven through a solution.

Rice University's nanosubs gain better fluorescent properties for tracking

Houston, TX | Posted on June 17th, 2016

The single-molecule vehicles introduced by the Rice lab of chemist James Tour last year may someday be used to deliver drugs or other cargo. The new version built and tested with collaborators at Tel Aviv University in Israel is the subject of a recent paper in the American Chemical Society journal Organic Letters.

The first nanosub, USN-1, could be monitored but not imaged by a technique that would irradiate it with light for very short times. But that did not offer information about the submersible's trajectory, according to lead author Víctor García-Lopéz, a former Rice graduate student. The latest model, the 334-atom USN-2, can be viewed by single-molecule microscopy for at least 1.5 seconds, long enough for 30 frames of video.

"This makes it possible for us to track the trajectory of a single nanosubmersible," Tour said. "It should lead to a better understanding of how our vehicles move."

The lab attached cyclooctatetraene (COT) to the molecule's body and motor to keep them from bleaching, which quenches fluorescence. The light-driven motor developed by scientists in the Netherlands is a tail-like ligand that spins about a million times per second. The new subs, like the originals, are capable of moving 15 meters per second over nanoscale distances, based on the thrust provided by each turn of the rotating motor. Between the frequent collisions that stop their forward motion, Tour said, they are "the fastest-moving molecules ever seen in solution."

The nanosubmarines still can't be steered in the traditional sense, Tour said. The team is satisfied for the moment with achieving "enhanced diffusion" that lets them figure out how to move a one-molecule vehicle in a solution of similarly sized molecules.

"The next step is to track these nanosubmarines in solution and see if we can use them to deliver cargo or interact with cells," Tour said.

###

Co-authors are Rice visiting scholar Shunsuke Kuwahara of Toho University, Japan; Angel Martí, an associate professor of chemistry of bioengineering and of materials science and nanoengineering at Rice; and Jonathan Jeffet, a master's student, and Yuval Ebenstein, a senior lecturer in chemistry, at Tel Aviv University.

García-Lopéz is now a postdoctoral researcher at ETH Zurich in Switzerland. Tour is the T.T. and W.F. Chao Chair in Chemistry as well as a professor of computer science and of materials science and nanoengineering at Rice.

The National Science Foundation, the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Yamada Science Foundation, the Israel Science Foundation and the European Research Councils supported the research.

####

About Rice University
Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation's top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,910 undergraduates and 2,809 graduate students, Rice's undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for best quality of life and for lots of race/class interaction by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger's Personal Finance. To read "What they're saying about Rice," go to tinyurl.com/RiceUniversityoverview.

Follow Rice News and Media Relations via Twitter @RiceUNews.

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