Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Nanodiamonds might prevent tooth loss after root canals: UCLA Dentistry research finds that the tiny particles strengthen the compound used to fill teeth and ward off infection

American Chemical Society/Dong-Keun Lee
A 3-D image of a tooth filled with nanodiamond-enhanced gutta percha, and an individual gutta percha point.
American Chemical Society/Dong-Keun Lee

A 3-D image of a tooth filled with nanodiamond-enhanced gutta percha, and an individual gutta percha point.

Abstract:
People undergoing root canals may have gained a powerful, if tiny, new ally. Researchers from the UCLA School of Dentistry have found that using nanodiamonds to fortify a material used in the procedure could significantly improve outcomes for patients.

Nanodiamonds might prevent tooth loss after root canals: UCLA Dentistry research finds that the tiny particles strengthen the compound used to fill teeth and ward off infection

Los Angeles, CA | Posted on October 19th, 2015

A paper on their research is published in the current issue of the peer-reviewed journal ACS Nano.

Nanodiamonds are tiny particles formed as byproducts of diamond refining and mining. Thousands of times smaller than the width of a human hair, they have been widely explored for use in dentistry, cancer therapy, imaging and regenerative medicine, among other applications.

Each year, more than 15 million root canal procedures are performed in the United States. Dentists' goal is to save their patients' teeth from infected dental "pulp" -- the part of the tooth that includes blood vessels and nerve tissue. During a root canal, inflamed dental pulp is removed and the empty space is then filled in with a polymer called gutta percha, which is used in part because it does not react within the body. But some root canals don't entirely remove the infection, and residual infection after root canals can lead to tooth loss.

In addition, traditional gutta percha has certain shortcomings, including a limited capacity to ward off infection and less-than-optimal rigidity.

To overcome those issues, the UCLA team developed and tested two types of reinforced gutta percha: One strengthened with nanodiamonds and another strengthened with nanodiamonds that had been pre-loaded with antibiotics.

To evaluate the first type, Sue Vin Kim and Adelheid Nerisa Limansubroto, study co-authors who are UCLA Dentistry students, filled actual teeth from human patients. Using conventional radiography and micro-computed tomography, or micro-CT, they showed that the nanodiamond-enhanced gutta percha could be used to fill the tooth. Like the traditional formulation, the nanodiamond-enhanced compound did leave small gaps in the canal -- where harmful bacteria could grow -- but the CT imaging showed that the enhanced material filled the space just as effectively as traditional gutta percha.

"Validating this novel material in teeth extracted from patients serves as a strong foundation for the potential translation of nanodiamond-reinforced gutta percha toward clinical testing," said Dean Ho, a senior author of the study and a professor of oral biology and medicine and co-director of UCLA Dentistry's Jane and Jerry Weintraub Center for Reconstructive Biotechnology.

In the research's second phase, the scientists tested nanodiamonds that had been loaded with amoxicillin, a broad-spectrum antibiotic used to combat infection. The drug-reinforced nanodiamonds, when combined with the gutta percha, effectively prevented bacteria growth.

"The nanodiamond-enhanced gutta percha combines many desirable properties into a single platform, including vastly improved mechanical characteristics and the ability to combat bacterial infection following a root canal," said Dong-Keun Lee, a postdoctoral scholar in Ho's lab.

The study involved UCLA researchers with expertise in a wide range of disciplines -- materials science, nanotechnology, drug delivery, toxicology, oral radiology, endodontics, microbiology and other fields.

"Through their ingenuity and collaboration, Professor Ho's team is poised to transform the way that dentistry is practiced," said Dr. No-Hee Park, dean of UCLA Dentistry and a co-author of the study.

During the next two years, the team plans optimize the formulation of the nanodiamond-reinforced gutta percha and begin clinical trials at UCLA.

###

Ho is also a professor of bioengineering and member of the UCLA Jonsson Comprehensive Cancer Center and the California NanoSystems Institute at UCLA. Other authors of the study were Albert Yen of the UCLA department of bioengineering and UCLA Dentistry; and Akrivoula Soundia, Yong Kim, Wenyuan Shi, Dr. Christine Hong, Dr. Sotirios Tetradis, Dr. Cun-Yu Wang and Dr. Mo Kang, all of UCLA Dentistry.

The study was supported by the National Cancer Institute, the National Science Foundation, the Wallace H. Coulter Foundation, the V Foundation for Cancer Research, the Society for Laboratory Automation and Screening, and Beckman Coulter Life Sciences.

####

For more information, please click here

Contacts:
Brianna Aldrich

310-206-0835

Copyright © UCLA

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

uSEE breakthrough unlocks the nanoscale world on standard biology lab equipment August 16th, 2019

Optofluidic chip with nanopore 'smart gate' developed for single molecule analysis: Programmable device enables on-demand delivery of individual biomolecules with feedback-controlled gating for high-throughput analysis August 16th, 2019

ULVAC Launches Revolutionary PZT Piezoelectric Thin-film Process Technology and HVM Solution for MEMS Sensors/Actuators: Enabling Reliable, High-quality Film Production for Next Generation Devices August 16th, 2019

RIT to upgrade Semiconductor and Microsystems Fabrication Laboratory through $1 million state grant: Upgrades to clean room will enhance university’s research capabilities in photonics, quantum technologies and smart systems August 16th, 2019

Govt.-Legislation/Regulation/Funding/Policy

uSEE breakthrough unlocks the nanoscale world on standard biology lab equipment August 16th, 2019

Optofluidic chip with nanopore 'smart gate' developed for single molecule analysis: Programmable device enables on-demand delivery of individual biomolecules with feedback-controlled gating for high-throughput analysis August 16th, 2019

Damaged hearts rewired with nanotube fibers: Texas Heart doctors confirm Rice-made, conductive carbon threads are electrical bridges August 14th, 2019

You're not so tough, h-BN: Rice University chemists find new path to make strong 2D material better for applications August 14th, 2019

Nanomedicine

uSEE breakthrough unlocks the nanoscale world on standard biology lab equipment August 16th, 2019

Optofluidic chip with nanopore 'smart gate' developed for single molecule analysis: Programmable device enables on-demand delivery of individual biomolecules with feedback-controlled gating for high-throughput analysis August 16th, 2019

RIT to upgrade Semiconductor and Microsystems Fabrication Laboratory through $1 million state grant: Upgrades to clean room will enhance university’s research capabilities in photonics, quantum technologies and smart systems August 16th, 2019

Probing the Origin of Alzheimer’s . . . with Transistors: Novel high-sensitivity detector could aid in early diagnosis August 15th, 2019

Discoveries

uSEE breakthrough unlocks the nanoscale world on standard biology lab equipment August 16th, 2019

Optofluidic chip with nanopore 'smart gate' developed for single molecule analysis: Programmable device enables on-demand delivery of individual biomolecules with feedback-controlled gating for high-throughput analysis August 16th, 2019

Probing the Origin of Alzheimer’s . . . with Transistors: Novel high-sensitivity detector could aid in early diagnosis August 15th, 2019

Damaged hearts rewired with nanotube fibers: Texas Heart doctors confirm Rice-made, conductive carbon threads are electrical bridges August 14th, 2019

Materials/Metamaterials

You're not so tough, h-BN: Rice University chemists find new path to make strong 2D material better for applications August 14th, 2019

A modified device fabrication process achieves enhanced spin transport in graphene August 6th, 2019

Rice lab produces simple fluorescent surfactants: Compounds show promise for use in medicine, manufacturing August 5th, 2019

Wood You Like Some Fresh Water? New treatment for wood makes a membrane to extract fresh water August 5th, 2019

Announcements

uSEE breakthrough unlocks the nanoscale world on standard biology lab equipment August 16th, 2019

Optofluidic chip with nanopore 'smart gate' developed for single molecule analysis: Programmable device enables on-demand delivery of individual biomolecules with feedback-controlled gating for high-throughput analysis August 16th, 2019

ULVAC Launches Revolutionary PZT Piezoelectric Thin-film Process Technology and HVM Solution for MEMS Sensors/Actuators: Enabling Reliable, High-quality Film Production for Next Generation Devices August 16th, 2019

RIT to upgrade Semiconductor and Microsystems Fabrication Laboratory through $1 million state grant: Upgrades to clean room will enhance university’s research capabilities in photonics, quantum technologies and smart systems August 16th, 2019

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

uSEE breakthrough unlocks the nanoscale world on standard biology lab equipment August 16th, 2019

Optofluidic chip with nanopore 'smart gate' developed for single molecule analysis: Programmable device enables on-demand delivery of individual biomolecules with feedback-controlled gating for high-throughput analysis August 16th, 2019

Probing the Origin of Alzheimer’s . . . with Transistors: Novel high-sensitivity detector could aid in early diagnosis August 15th, 2019

Damaged hearts rewired with nanotube fibers: Texas Heart doctors confirm Rice-made, conductive carbon threads are electrical bridges August 14th, 2019

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Damaged hearts rewired with nanotube fibers: Texas Heart doctors confirm Rice-made, conductive carbon threads are electrical bridges August 14th, 2019

You're not so tough, h-BN: Rice University chemists find new path to make strong 2D material better for applications August 14th, 2019

Researchers embrace imperfection to improve biomolecule transport August 8th, 2019

RIT awarded NSF funding to conceptualize Quantum Photonic Institute: RIT will develop plan for open-access Quantum Foundry for quantum photonic circuits August 7th, 2019

Dental

Novel nanoparticle-based approach detects and treats oral plaque without drugs August 17th, 2018

Dental plaque is no match for catalytic nanoparticles: Twice-daily rinses of FDA-approved nanoparticles broke apart oral biofilms and prevented tooth decay in a study led by Penn researchers August 8th, 2018

Detecting the birth and death of a phonon June 7th, 2018

MEET THE WOMAN BEHIND THE NANOTECHNOLOGY THAT REVOLUTIONIZED DENTAL CARE May 1st, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project