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Home > Press > Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples

Abstract:
Ever heard of the water window? It consists of radiations in the 3.3 to 4.4 nanometre range, which are not absorbed by the water in biological tissues. New theoretical findings show that it is possible to develop coherent radiations within the water window. These could be the basis of an optimal technique to obtain a high-contrast image of the biological samples or to be used in high-precision spectroscopy. Now, a new theoretical study identifies the physical mechanism needed to efficiently generate the harmonic radiations—which are multiples of an incoming laser's frequency—at high laser intensities that occur beyond the saturation threshold of atoms and molecules. These findings, aimed at improving conventional methods of coherent radiation production to reach the water window, were recently published in the EPJ D by José Pérez-Hernández from the Centre for Pulsated Laser, CLPU, in Salamanca, Spain, and colleagues.

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples

Heidelberg, Germany and New York, NY | Posted on August 21st, 2014

When an intense and short laser pulse interacts with an atom or molecule, one of the resultant physical processes is the High-order Harmonic Generation (HHG) process, which is capable of changing the driving laser pulse into new harmonic frequencies. HHG also provides a direct way to synthesise atto-second pulses (10-18s range) and produce coherent radiation in the extreme UV range, dubbed XUV and EUV.

In previous similar work, studies focused on hydrogen as the atomic target. In the present work, the authors extend the study to argon atoms—a gas typically providing a high enough frequency conversion efficiency to detect the HHG. The authors use the same formalism as in hydrogen studies, consisting in mathematical equations combined with a quantum mechanical approach using numerical computation and providing a quantitative description of the HHG spectrum. The experimental confirmation of the reported prediction, however, still remains a challenge.

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Reference: Pérez-Hernández, J. A. et al. (2014). High order harmonic generation at high laser intensities beyond the tunnel regime. European Physical Journal D. DOI: 10.1140/epjd/e2014-50086-6:

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