Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Immune cells get cancer-fighting boost from nanomaterials

Abstract:
Scientists at Yale University have developed a novel cancer immunotherapy that rapidly grows and enhances a patient's immune cells outside the body using carbon nanotube-polymer composites; the immune cells can then be injected back into a patient's blood to boost the immune response or fight cancer.

Immune cells get cancer-fighting boost from nanomaterials

New Haven, CT | Posted on August 13th, 2014

As reported Aug. 3 in Nature Nanotechnology, the researchers used bundled carbon nanotubes (CNTs) to incubate cytotoxic T cells, a type of white blood cell that is important to immune system functions. According to the researchers, the topography of the CNTs enhances interactions between cells and long-term cultures, providing a fast and effective stimulation of the cytotoxic T cells that are important for eradicating cancer.

The researchers modified the CNTs by chemically binding them to polymer nanoparticles that held Interleukin-2, a cell signaling protein that encourages T cell growth and proliferation. Additionally, in order to mimic the body's methods for stimulating cytotoxic T cell proliferation, the scientists seeded the surfaces of the CNTs with molecules that signaled which of the patient's cells were foreign or toxic and should be attacked.

Over the span of 14 days, the number of T cells cultured on the composite nanosystem expanded by a factor of 200, according to the researchers. Also, the method required 1,000 times less Interleukin-2 than conventional culture conditions. A magnet was used to separate the CNT-polymer composites from the T cells prior to injection.

"In repressing the body's immune response, tumors are like a castle with a moat around it," says Tarek Fahmy, an associate professor of biomedical engineering and the study's principal investigator. "Our method recruits significantly more cells to the battle and arms them to become superkillers."

According to Fahmy, previous procedures for boosting antigen-specific T cells required exposing the patient's harvested immune cells to other cells that stimulate activation and proliferation, a costly procedure that risks an adverse reaction to foreign cells. The Yale team's use of magnetic CNT-polymer composites eliminates that risk by using simple, inexpensive magnets.

"Modulatory nanotechnologies can present unique opportunities for promising new therapies such as T cell immunotherapy," says Tarek Fadel, lead author of the research and a Yale postdoc who is currently a staff scientist with the National Nanotechnology Coordination Office. "Engineers are progressing toward the design of the next generations of nanomaterials, allowing for further breakthrough in many fields, including cancer research."

Two additional Yale engineering faculty contributed to this article: Gary Haller, the Henry Prentiss Becton Professor of Engineering and Applied Science and a professor of chemistry; and Lisa Pfefferle, the C. Baldwin Sawyer Professor of Chemical and Environmental Engineering. Other authors include Fiona Sharp, Nalini Vudattu, Ragy Ragheb, Justin Garyu, Dongin Kim, Enping Hong, Nan Li, Sune Justesen, and Kevan Herold.

####

For more information, please click here

Contacts:
Jim Shelton
(203) 432-3881

Copyright © Yale University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Stanford breakthrough heralds super-efficient light-based computers: Light can transmit more data while consuming far less power than electricity, and an engineering feat brings optical data transport closer to replacing wires May 29th, 2015

Donuts, math, and superdense teleportation of quantum information May 29th, 2015

OSU researchers prove magnetism can control heat, sound: Team leverages OSC services to help confirm, interpret experimental findings May 29th, 2015

Two UCSB Professors Receive Early Career Research Awards: The Department of Energy’s award for young scientists acknowledges UC Santa Barbara’s standing as a top tier research institution May 29th, 2015

Nanotubes/Buckyballs/Fullerenes

Global Carbon Nanotubes (CNT) Market Expected To Reach USD 3.42 Billion By 2022 May 29th, 2015

SouthWest NanoTechnologies Introduces AgeNT™ Transparent Conductor System at SID Display Week, Booth #543 May 28th, 2015

Physicists precisely measure interaction between atoms and carbon surfaces May 28th, 2015

Basel physicists develop efficient method of signal transmission from nanocomponents May 23rd, 2015

Nanomedicine

New chip makes testing for antibiotic-resistant bacteria faster, easier: Researchers at the University of Toronto design diagnostic chip to reduce testing time from days to one hour, allowing doctors to pick the right antibiotic the first time May 28th, 2015

Arrowhead to Present at Jefferies 2015 Healthcare Conference May 27th, 2015

Seeing the action: UCSB researchers develop a novel device to image the minute forces and actions involved in cell membrane hemifusion May 27th, 2015

Nanotechnology identifies brain tumor types through MRI 'virtual biopsy' in animal studies: If results are confirmed in humans, tumor cells could someday be diagnosed by MRI imaging and treated with tumor-specific IV injections; new NIH grant will fund future study May 27th, 2015

Discoveries

Stanford breakthrough heralds super-efficient light-based computers: Light can transmit more data while consuming far less power than electricity, and an engineering feat brings optical data transport closer to replacing wires May 29th, 2015

Donuts, math, and superdense teleportation of quantum information May 29th, 2015

OSU researchers prove magnetism can control heat, sound: Team leverages OSC services to help confirm, interpret experimental findings May 29th, 2015

New technique speeds nanoMRI imaging: Multiplexing technique for nanoscale magnetic resonance imaging developed by researchers in Switzerland cuts normal scan time from two weeks to two days May 28th, 2015

Materials/Metamaterials

SouthWest NanoTechnologies Introduces AgeNT™ Transparent Conductor System at SID Display Week, Booth #543 May 28th, 2015

Physicists precisely measure interaction between atoms and carbon surfaces May 28th, 2015

Linking superconductivity and structure May 28th, 2015

Controlled Release of Anticorrosive Materials in Spot by Nanocarriers May 27th, 2015

Announcements

Stanford breakthrough heralds super-efficient light-based computers: Light can transmit more data while consuming far less power than electricity, and an engineering feat brings optical data transport closer to replacing wires May 29th, 2015

Donuts, math, and superdense teleportation of quantum information May 29th, 2015

OSU researchers prove magnetism can control heat, sound: Team leverages OSC services to help confirm, interpret experimental findings May 29th, 2015

Two UCSB Professors Receive Early Career Research Awards: The Department of Energy’s award for young scientists acknowledges UC Santa Barbara’s standing as a top tier research institution May 29th, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Stanford breakthrough heralds super-efficient light-based computers: Light can transmit more data while consuming far less power than electricity, and an engineering feat brings optical data transport closer to replacing wires May 29th, 2015

Donuts, math, and superdense teleportation of quantum information May 29th, 2015

OSU researchers prove magnetism can control heat, sound: Team leverages OSC services to help confirm, interpret experimental findings May 29th, 2015

Global Carbon Nanotubes (CNT) Market Expected To Reach USD 3.42 Billion By 2022 May 29th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project