Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > JPK reports on the use of the ForceRobot system to study the dynamics of biomacromolecules at Nanjing University

Professor Yi Cao, right, and two of his students with the JPK ForceRobot® system in the Institute of Biophysics at Nanjing University.
Professor Yi Cao, right, and two of his students with the JPK ForceRobot® system in the Institute of Biophysics at Nanjing University.

Abstract:
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the study of how force regulates the structures and conformational dynamics of biomacromolecules using AFM-based single molecule force spectroscopy, a project of Professor Yi Cao of Nanjing University.

JPK reports on the use of the ForceRobot system to study the dynamics of biomacromolecules at Nanjing University

Berlin, Germany | Posted on March 13th, 2014

Professor Yi Cao is a member of the Institute of Biophysics located in the Physics Department of Nanjing University. The main focus of his group is to study how force regulates the structures and conformational dynamics of biomacromolecules using AFM based single molecule force spectroscopy. As force has been revealed as an important signal that regulates many biologic processes (e.g. cell adhesion, muscle contraction, membrane fusion and etc.), their study will be helpful for the understanding of the mechanism underlying these processes. In order to study the conformational change of proteins under force, there is the need for a tool that allows the accurate application of force in the pN range and then to measure the change in distance at the nm resolution. AFM is an ideal tool to fulfil this criterion and Professor Cao thinks that JPK's AFM is one of the best AFMs for biological applications.

Professor Cao first got to know ForceRobot when he was a graduate student at the University of British Columbia in Canada. He notes "I saw the very first version of ForceRobot in a SPM conference in 2007. It was so amazing to get the experiments done automatically without attendance using the ForceRobot®. I thought that this could save a lot of tedious routine manipulation time. I was impressed that the machine can be controlled remotely through internet or smartphone, which means that the operator can leave experiments running when at home or away from the laboratory. I can change many experimental parameters using the Experimentplanner™. Then, when I come back to work, thousands of curves have been collected. All you need to do is to analyze them and think about the science related to these data. Subsequently, I bought a ForceRobot when I started my own research group in Nanjing University in 2010. The software is getting better and better, especially the data analysis function."

Continuing, Professor Cao said that "before using ForceRobot, I used a custom-built AFM (commercial heads and piezos). We need to spend quite a lot of time for instrumentation and sometimes the custom-built AFM gave us more flexibility for different kinds of experiments. With the advent of the ForceRobot, we have a system which greatly improves the quantity and quality of data."

For more details about JPK's ForceRobot® system and applications for the bio & nano sciences, please contact JPK on +49 30533112070, visit the web site: www.jpk.com or see more on Facebook: www.jpk.com/facebook and on You Tube: www.youtube.com/jpkinstruments.

####

About JPK Instruments
JPK Instruments AG is a world-leading manufacturer of nanoanalytic instruments - particularly atomic force microscope (AFM) systems and optical tweezers - for a broad range of applications reaching from soft matter physics to nano-optics, from surface chemistry to cell and molecular biology. From its earliest days applying atomic force microscope (AFM) technology, JPK has recognized the opportunities provided by nanotechnology for transforming life sciences and soft matter research. This focus has driven JPK’s success in uniting the worlds of nanotechnology tools and life science applications by offering cutting-edge technology and unique applications expertise. Headquartered in Berlin and with direct operations in Dresden, Cambridge (UK), Singapore, Tokyo and Paris (France), JPK maintains a global network of distributors and support centers and provides on the spot applications and service support to an ever-growing community of researchers.

For more information, please click here

Contacts:
JPK Instruments AG
Bouchéstrasse 12
Haus 2, Aufgang C
Berlin 12435
Germany
T +49 30533112070
F +49 30 5331 22555
http://www.jpk.com/



Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA
United Kingdom
T +44(0)1799 521881
M +44(0)7843 012997
http://www.talking-science.com/

Copyright © JPK Instruments

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

Imaging

A new cheap and efficient method to improve SERS, an ultra-sensitive chemical detection technique October 28th, 2014

Molecular beacons shine light on how cells 'crawl' October 27th, 2014

National Synchrotron Light Source II Achieves 'First Light' October 23rd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Nanomedicine

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Production of Biocompatible Polymers in Iran October 30th, 2014

Amorphous Coordination Polymer Particles as alternative to classical nanoplatforms for nanomedicine October 30th, 2014

'Electronic skin' could improve early breast cancer detection October 29th, 2014

Discoveries

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

Announcements

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

Tools

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

A new cheap and efficient method to improve SERS, an ultra-sensitive chemical detection technique October 28th, 2014

New Compact SIMS at 61st AVS | Visit us on Booth 311 October 28th, 2014

New nanodevice to improve cancer treatment monitoring October 27th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE