Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > JPK reports on the use of the ForceRobot system to study the dynamics of biomacromolecules at Nanjing University

Professor Yi Cao, right, and two of his students with the JPK ForceRobot® system in the Institute of Biophysics at Nanjing University.
Professor Yi Cao, right, and two of his students with the JPK ForceRobot® system in the Institute of Biophysics at Nanjing University.

Abstract:
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the study of how force regulates the structures and conformational dynamics of biomacromolecules using AFM-based single molecule force spectroscopy, a project of Professor Yi Cao of Nanjing University.

JPK reports on the use of the ForceRobot system to study the dynamics of biomacromolecules at Nanjing University

Berlin, Germany | Posted on March 13th, 2014

Professor Yi Cao is a member of the Institute of Biophysics located in the Physics Department of Nanjing University. The main focus of his group is to study how force regulates the structures and conformational dynamics of biomacromolecules using AFM based single molecule force spectroscopy. As force has been revealed as an important signal that regulates many biologic processes (e.g. cell adhesion, muscle contraction, membrane fusion and etc.), their study will be helpful for the understanding of the mechanism underlying these processes. In order to study the conformational change of proteins under force, there is the need for a tool that allows the accurate application of force in the pN range and then to measure the change in distance at the nm resolution. AFM is an ideal tool to fulfil this criterion and Professor Cao thinks that JPK's AFM is one of the best AFMs for biological applications.

Professor Cao first got to know ForceRobot when he was a graduate student at the University of British Columbia in Canada. He notes "I saw the very first version of ForceRobot in a SPM conference in 2007. It was so amazing to get the experiments done automatically without attendance using the ForceRobot®. I thought that this could save a lot of tedious routine manipulation time. I was impressed that the machine can be controlled remotely through internet or smartphone, which means that the operator can leave experiments running when at home or away from the laboratory. I can change many experimental parameters using the Experimentplanner™. Then, when I come back to work, thousands of curves have been collected. All you need to do is to analyze them and think about the science related to these data. Subsequently, I bought a ForceRobot when I started my own research group in Nanjing University in 2010. The software is getting better and better, especially the data analysis function."

Continuing, Professor Cao said that "before using ForceRobot, I used a custom-built AFM (commercial heads and piezos). We need to spend quite a lot of time for instrumentation and sometimes the custom-built AFM gave us more flexibility for different kinds of experiments. With the advent of the ForceRobot, we have a system which greatly improves the quantity and quality of data."

For more details about JPK's ForceRobot® system and applications for the bio & nano sciences, please contact JPK on +49 30533112070, visit the web site: www.jpk.com or see more on Facebook: www.jpk.com/facebook and on You Tube: www.youtube.com/jpkinstruments.

####

About JPK Instruments
JPK Instruments AG is a world-leading manufacturer of nanoanalytic instruments - particularly atomic force microscope (AFM) systems and optical tweezers - for a broad range of applications reaching from soft matter physics to nano-optics, from surface chemistry to cell and molecular biology. From its earliest days applying atomic force microscope (AFM) technology, JPK has recognized the opportunities provided by nanotechnology for transforming life sciences and soft matter research. This focus has driven JPK’s success in uniting the worlds of nanotechnology tools and life science applications by offering cutting-edge technology and unique applications expertise. Headquartered in Berlin and with direct operations in Dresden, Cambridge (UK), Singapore, Tokyo and Paris (France), JPK maintains a global network of distributors and support centers and provides on the spot applications and service support to an ever-growing community of researchers.

For more information, please click here

Contacts:
JPK Instruments AG
Bouchéstrasse 12
Haus 2, Aufgang C
Berlin 12435
Germany
T +49 30533112070
F +49 30 5331 22555
http://www.jpk.com/



Talking Science Limited
39 de Bohun Court
Saffron Walden
Essex CB10 2BA
United Kingdom
T +44(0)1799 521881
M +44(0)7843 012997
http://www.talking-science.com/

Copyright © JPK Instruments

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Cambrios at CEATEC - Japan 2016 September 29th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Leti and Taiwanese Tech Organizations Sponsoring Workshop in Taipei on MEMS, IoT, Smart Lighting Applications, System Reliability & Security September 28th, 2016

Imaging

Leti and Taiwanese Tech Organizations Sponsoring Workshop in Taipei on MEMS, IoT, Smart Lighting Applications, System Reliability & Security September 28th, 2016

Oxford Instruments is ‘Bringing the Nanoworld Together’ in India once again - 22 - 23 November 2016 | IISc Bangalore September 21st, 2016

Bruker Introduces Complete Commercial AFM-Based SECM Solution: PeakForce SECM Mode Enables Previously Unobtainable Electrochemical Information September 20th, 2016

Nanomedicine

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

Discoveries

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

UNAM develops successful nano edible coating which increases life food September 27th, 2016

Announcements

Nanosensors could help determine tumors’ ability to remodel tissue: Measuring enzyme levels could help doctors select appropriate treatments September 29th, 2016

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Cambrios at CEATEC - Japan 2016 September 29th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Tools

Oxford Instruments systems now facilitate water purification technology September 27th, 2016

Dr Barbara Armbruster promoted to Worldwide Sales and Marketing Director for XEI Scientific September 27th, 2016

Oxford Instruments is ‘Bringing the Nanoworld Together’ in India once again - 22 - 23 November 2016 | IISc Bangalore September 21st, 2016

Bruker Introduces Complete Commercial AFM-Based SECM Solution: PeakForce SECM Mode Enables Previously Unobtainable Electrochemical Information September 20th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic