Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > A New Postal Code for Cancer: Freiburg researchers find purely chemical way to target therapeutic nano-containers to cells

Immunofluorescence image shows nanoparticles targeted to endothelial cells. The red particles turn orange when overlapping with the green caveolin in the lipid rafts of the cells. Source: Julia Voigt / Prasad Shastri
Immunofluorescence image shows nanoparticles targeted to endothelial cells. The red particles turn orange when overlapping with the green caveolin in the lipid rafts of the cells.

Source: Julia Voigt / Prasad Shastri

Abstract:
Scientists have discovered that a polymer can provide a key to get into tumors: Prof. Prasad Shastri, Director of the Institute of Macromolecular Chemistry and core member of the cluster of excellence BIOSS Centre for Biological Signalling Studies at the University of Freiburg, and graduate students Julia Voigt and Jon Christensen have developed a new paradigm to home nanoparticles, containers that measure a few 100 nanometers in size, to endothelial cells.

A New Postal Code for Cancer: Freiburg researchers find purely chemical way to target therapeutic nano-containers to cells

Freiburg, Germany | Posted on February 12th, 2014

Using just charged polymers with the right affinity for cell lipids the team has developed nanoparticles that can recognize specific cell types simply by their chemical properties. "This is a remarkable discovery, as it allows for the first time to target a specific cell type purely through biophysical principles, and without using the traditional ligand-receptor approach" says Prof. Shastri who led the study. Until now researchers placed molecules on nanoparticles that can latch onto proteins on cell surface - called receptors.

These receptors act as an address or a biological postal code. However in tumors these addresses can change rapidly with time. To solve this lack of precision Shastri and team developed particles that are delivered to endothelial cells using a biophysical approach. "This delivery approach does not require a biological postal code for targeting of nanoparticles and is an important step forward in developing nanoparticle based systems for treating cancers" says Julia Voigt the lead author of the paper.

Cancers are very hungry tissues and they need constant nourishment. This is provided through their own supply of blood vessels. "By going after endothelial cells that make up these blood vessels, we can starve the tumor or kill it with one payload" says Jon Christensen who is a co-author on this study and works on tumor metastasis.

Nanoparticles are used to deliver therapeutics in treating cancers. These very small pills, cornerstones of nanomedicine, get injected into the body and reach the tumor cells via the bloodstream. When they find the targeted cells, they need to be eaten so that the drug can act within the cell. This mechanism is called receptor-mediated endocytosis. Shastri and his team looked to develop a new approach that targets a transport process that is dominant in endothelial cells. It turns out that a structure called caveolae is found in large amounts on endothelial cells. Caveolae are "lipid rafts" on the cell membrane and are one of the doors into the endothelial cells. Prof. Shastri and his team discovered that by decorating nano-pills made of lipids with negatively charged polymers, nanoparticles can preferentially enter through this door. "How exactly these charged polymers enable the nanoparticles to unlock this door we are not sure yet, but we feel confident that with further studies this method could usher in a new approach to delivery of drugs in general" says Shastri. This project was funded by supported by INTERREG and the cluster of excellence BIOSS Centre for Biological Signalling Studies.

Full bibliographic information

Julia Voigt, Jon Christensen, V. Prasad Shastri: Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolae. PNAS Online Early Edition 2014.

####

About Albert-Ludwigs-Universität Freiburg
The University of Freiburg was founded in 1457 as a classical comprehensive university, making it one of the oldest higher education institutions in Germany. Successful in the Excellence Initiative, the university also boasts an illustrious history with numerous Nobel Prize recipients. Brilliant scholars and creative thinking distinguish it today as a modern top-notch university well equipped for the challenges of the 21st century.

For more information, please click here

Contacts:
Nicolas Scherger


Prof. Dr. V. Prasad Shastri
Institute for Macromolecular Chemistry / BIOSS Centre for Biological Signalling Studies
University of Freiburg
Phone: 0761/203-6268

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

National Science Foundation Selects SUNY Poly CNSE for Expanded $2.1M Northeast Advanced Technological Education Center: NSF Center Locates to NanoCollege in Support of Flourishing Tech Industry in NYS September 1st, 2015

RUSNANOPRIZE Directorate Announces New Deadline for Nominations Submission – September 11, 2015 September 1st, 2015

$200K Awarded to Develop In Vitro Lung Test for Toxicity of Inhaled Nanomaterials: In Vitro Lung Test Designed to Protect Human Health and Replace Animal Testing September 1st, 2015

Hot electrons point the way to perfect light absorption: Physicists study how to achieve perfect absorption of light with the help of rough ultrathin films September 1st, 2015

Imaging

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

50 Years of Scanning Electron Microscopy from ZEISS: ZEISS celebrates the birth of the first commercial scanning electron microscope in 1965 August 26th, 2015

Announcing Oxford Instruments and School of Physics signing a Memorandum of Understanding August 26th, 2015

Kwansei Gakuin University in Hyogo, Japan, uses Raman microscopy to study crystallographic defects in silicon carbide wafers August 25th, 2015

Nanomedicine

Using DNA origami to build nanodevices of the future September 1st, 2015

Efficiency of Nanodrug Containing Antibiotics in Treatment of Infectious Diseases Evaluated August 31st, 2015

Researchers use DNA 'clews' to shuttle CRISPR-Cas9 gene-editing tool into cells August 30th, 2015

Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs August 29th, 2015

Discoveries

Hot electrons point the way to perfect light absorption: Physicists study how to achieve perfect absorption of light with the help of rough ultrathin films September 1st, 2015

Using DNA origami to build nanodevices of the future September 1st, 2015

Scientists 'squeeze' light one particle at a time: A team of scientists have measured a bizarre effect in quantum physics, in which individual particles of light are said to have been 'squeezed' -- an achievement which at least one textbook had written off as hopeless September 1st, 2015

Using ultrathin sheets to discover new class of wrapped shapes: UMass Amherst materials researchers describe a new regime of wrapped shapes August 31st, 2015

Announcements

$200K Awarded to Develop In Vitro Lung Test for Toxicity of Inhaled Nanomaterials: In Vitro Lung Test Designed to Protect Human Health and Replace Animal Testing September 1st, 2015

Hot electrons point the way to perfect light absorption: Physicists study how to achieve perfect absorption of light with the help of rough ultrathin films September 1st, 2015

Using DNA origami to build nanodevices of the future September 1st, 2015

Nanotech could rid cattle of ticks, with less collateral damage September 1st, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Hot electrons point the way to perfect light absorption: Physicists study how to achieve perfect absorption of light with the help of rough ultrathin films September 1st, 2015

Using DNA origami to build nanodevices of the future September 1st, 2015

Nanotech could rid cattle of ticks, with less collateral damage September 1st, 2015

Scientists 'squeeze' light one particle at a time: A team of scientists have measured a bizarre effect in quantum physics, in which individual particles of light are said to have been 'squeezed' -- an achievement which at least one textbook had written off as hopeless September 1st, 2015

Tools

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

Nanometrics to Participate in the Citi 2015 Global Technology Conference August 26th, 2015

50 Years of Scanning Electron Microscopy from ZEISS: ZEISS celebrates the birth of the first commercial scanning electron microscope in 1965 August 26th, 2015

Announcing Oxford Instruments and School of Physics signing a Memorandum of Understanding August 26th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic