Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Researchers dismantle bacteria's war machinery: A nano-machine cell killer: EPFL researchers decipher the attack strategy of certain bacteria, including the infamous Staphylococcus aureus

© photos.com
© photos.com

Abstract:
This is a veritable mechanics of aggression on the nanoscale. Certain bacteria, including Staphylococcus aureus, have the ability to deploy tiny darts. This biological weapon kills the host cell by piercing the membrane. Researchers at EPFL have dismantled, piece by piece, this intriguing little machine and found an assembly of proteins that, in unfolding at the right time, takes the form of a spur. Published in Nature Chemical Biology, this discovery offers new insight into the fight against pathogens that are increasingly resistant to antibiotics.

Researchers dismantle bacteria's war machinery: A nano-machine cell killer: EPFL researchers decipher the attack strategy of certain bacteria, including the infamous Staphylococcus aureus

Lausanne, Switzerland | Posted on August 5th, 2013

To attack the host cell, the weapon must first attach. On the surface of the aggressor is a mechanism composed of seven proteins that are folded over and assembled into a ring. The researchers were able to show how, in time, these long molecules unfold to form a kind of spur.

The trigger is just another part of the machine - a peptide, or a small organic molecule. When exposed to the enzymes of the host organism, it detaches. The balance of the assembly adjusts: the proteins adopt a new form, spreading out in a circular motion to form a spur, which then pierces the membrane of the host cell.

Mechanical at the molecular level

No chemical reaction is involved in these biological weapons. This is a mechanical phenomenon, albeit on the molecular level. Matteo Dal Peraro, co-author of this study, also uses the term "nanomachine" to refer to this tool of aggression.

The EPFL researchers have worked on strains of Aeromonas hydrophila - a bacterium well-known among travelers for the intestinal disorders it causes. In Petri dishes the researchers could, at will, cause the formation of these darts, thereby exposing microorganisms to digestive enzymes. They were able to model precisely how each protein dynamically rearranges, once the peptide is missing, to form the spur.

Hinder the attack mechanism

For co-author Gisou Van der Goot, this discovery opens new therapeutic perspectives, for example in cases of nosocomial infection staphylococci. "We could imagine catheters coated with substitute peptides," she says. "They could prevent the formation of the ring and, thus, the spur. We would avoid many hospital infections."

The concept is to address the weaponry of the bacteria rather than the bacteria itself. This is particularly attractive at a time when multiple antibiotic resistances are becoming increasingly common. "This approach would have the advantage of not causing mutations, and thereby resistance, in pathogenic bacteria," says the researcher.

####

About Ecole Polytechnique Fédérale de Lausanne
EPFL is Europe’s most cosmopolitan technical university. It receives students, professors and staff from over 120 nationalities. With both a Swiss and international calling, it is therefore guided by a constant wish to open up; its missions of teaching, research and partnership impact various circles: universities and engineering schools, developing and emerging countries, secondary schools and gymnasiums, industry and economy, political circles and the general public.

For more information, please click here

Contacts:
Matteo Dal Peraro

41-798-083-220

Copyright © Ecole Polytechnique Fédérale de Lausanne

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Matteo T Degiacomi,Ioan Iacovache, Lucile Pernot, Mohamed Chami, Misha Kudryashev, Henning Stahlberg, F Gisou van der Goot & Matteo Dal Peraro, Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism, in Nature Chemical Biology (2013) doi:10.1038/nchembio.1312:

Related News Press

News and information

ICN2 researchers compute unprecedented values for spin lifetime anisotropy in graphene November 17th, 2017

Math gets real in strong, lightweight structures: Rice University researchers use 3-D printers to turn century-old theory into complex schwarzites November 16th, 2017

The stacked color sensor: True colors meet minimization November 16th, 2017

Nanometrics to Participate in the 6th Annual NYC Investor Summit 2017 November 16th, 2017

Molecular Machines

How to draw electricity from the bloodstream: A one-dimensional fluidic nanogenerator with a high power-conversion efficiency September 11th, 2017

First 3-D observation of nanomachines working inside cells: Researchers headed by IRB Barcelona combine genetic engineering, super-resolution microscopy and biocomputation to allow them to see in 3-D the protein machinery inside living cells January 27th, 2017

Micro-bubbles make big impact: Research team develops new ultrasound-powered actuator to develop micro robot November 25th, 2016

Scientists come up with light-driven motors to power nanorobots of the future: Researchers from Russia and Ukraine propose a nanosized motor controlled by a laser with potential applications across the natural sciences and medicine November 11th, 2016

Nanomedicine

Nanobiotix presented new clinical and pre-clinical data confirming NBTXR3’s significant potential role in Immuno-Oncology at SITC Annual Meeting November 14th, 2017

Arrowhead to Present at 29th Annual Piper Jaffray Healthcare Conference November 14th, 2017

A new way to mix oil and water: Condensation-based method developed at MIT could create stable nanoscale emulsions November 8th, 2017

Nanoshells could deliver more chemo with fewer side effects: In vitro study verifies method for remotely triggering release of cancer drugs November 8th, 2017

Discoveries

ICN2 researchers compute unprecedented values for spin lifetime anisotropy in graphene November 17th, 2017

Math gets real in strong, lightweight structures: Rice University researchers use 3-D printers to turn century-old theory into complex schwarzites November 16th, 2017

The stacked color sensor: True colors meet minimization November 16th, 2017

Counterfeits and product piracy can be prevented by security features, such as printed 3-D microstructures: Forgeries and product piracy are detrimental to society and industry -- 3-D microstructures can increase security -- KIT researchers develop innovative fluorescent 3-D stru November 15th, 2017

Announcements

ICN2 researchers compute unprecedented values for spin lifetime anisotropy in graphene November 17th, 2017

Math gets real in strong, lightweight structures: Rice University researchers use 3-D printers to turn century-old theory into complex schwarzites November 16th, 2017

The stacked color sensor: True colors meet minimization November 16th, 2017

Nanometrics to Participate in the 6th Annual NYC Investor Summit 2017 November 16th, 2017

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

ICN2 researchers compute unprecedented values for spin lifetime anisotropy in graphene November 17th, 2017

Math gets real in strong, lightweight structures: Rice University researchers use 3-D printers to turn century-old theory into complex schwarzites November 16th, 2017

The stacked color sensor: True colors meet minimization November 16th, 2017

Counterfeits and product piracy can be prevented by security features, such as printed 3-D microstructures: Forgeries and product piracy are detrimental to society and industry -- 3-D microstructures can increase security -- KIT researchers develop innovative fluorescent 3-D stru November 15th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project