Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Researchers dismantle bacteria's war machinery: A nano-machine cell killer: EPFL researchers decipher the attack strategy of certain bacteria, including the infamous Staphylococcus aureus

© photos.com
© photos.com

Abstract:
This is a veritable mechanics of aggression on the nanoscale. Certain bacteria, including Staphylococcus aureus, have the ability to deploy tiny darts. This biological weapon kills the host cell by piercing the membrane. Researchers at EPFL have dismantled, piece by piece, this intriguing little machine and found an assembly of proteins that, in unfolding at the right time, takes the form of a spur. Published in Nature Chemical Biology, this discovery offers new insight into the fight against pathogens that are increasingly resistant to antibiotics.

Researchers dismantle bacteria's war machinery: A nano-machine cell killer: EPFL researchers decipher the attack strategy of certain bacteria, including the infamous Staphylococcus aureus

Lausanne, Switzerland | Posted on August 5th, 2013

To attack the host cell, the weapon must first attach. On the surface of the aggressor is a mechanism composed of seven proteins that are folded over and assembled into a ring. The researchers were able to show how, in time, these long molecules unfold to form a kind of spur.

The trigger is just another part of the machine - a peptide, or a small organic molecule. When exposed to the enzymes of the host organism, it detaches. The balance of the assembly adjusts: the proteins adopt a new form, spreading out in a circular motion to form a spur, which then pierces the membrane of the host cell.

Mechanical at the molecular level

No chemical reaction is involved in these biological weapons. This is a mechanical phenomenon, albeit on the molecular level. Matteo Dal Peraro, co-author of this study, also uses the term "nanomachine" to refer to this tool of aggression.

The EPFL researchers have worked on strains of Aeromonas hydrophila - a bacterium well-known among travelers for the intestinal disorders it causes. In Petri dishes the researchers could, at will, cause the formation of these darts, thereby exposing microorganisms to digestive enzymes. They were able to model precisely how each protein dynamically rearranges, once the peptide is missing, to form the spur.

Hinder the attack mechanism

For co-author Gisou Van der Goot, this discovery opens new therapeutic perspectives, for example in cases of nosocomial infection staphylococci. "We could imagine catheters coated with substitute peptides," she says. "They could prevent the formation of the ring and, thus, the spur. We would avoid many hospital infections."

The concept is to address the weaponry of the bacteria rather than the bacteria itself. This is particularly attractive at a time when multiple antibiotic resistances are becoming increasingly common. "This approach would have the advantage of not causing mutations, and thereby resistance, in pathogenic bacteria," says the researcher.

####

About Ecole Polytechnique Fédérale de Lausanne
EPFL is Europe’s most cosmopolitan technical university. It receives students, professors and staff from over 120 nationalities. With both a Swiss and international calling, it is therefore guided by a constant wish to open up; its missions of teaching, research and partnership impact various circles: universities and engineering schools, developing and emerging countries, secondary schools and gymnasiums, industry and economy, political circles and the general public.

For more information, please click here

Contacts:
Matteo Dal Peraro

41-798-083-220

Copyright © Ecole Polytechnique Fédérale de Lausanne

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Matteo T Degiacomi,Ioan Iacovache, Lucile Pernot, Mohamed Chami, Misha Kudryashev, Henning Stahlberg, F Gisou van der Goot & Matteo Dal Peraro, Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism, in Nature Chemical Biology (2013) doi:10.1038/nchembio.1312:

Related News Press

News and information

Promising Step Taken in Iran towards Treatment of Spinal Cord Injury August 3rd, 2015

Diagnosis of Salmonella Bacterium-Caused Food Poisoning by Biosensors August 3rd, 2015

Thin films offer promise for ferroelectric devices: Researchers at Tokyo Institute of Technology demystify the ferroelectric properties observed in hafnium-oxide-based thin films, revealing a potentially useful device material August 3rd, 2015

Kalam: versatility personified August 1st, 2015

Molecular Machines

Injectable electronics: New system holds promise for basic neuroscience, treatment of neuro-degenerative diseases June 8th, 2015

One step closer to a single-molecule device: Columbia Engineering researchers first to create a single-molecule diode -- the ultimate in miniaturization for electronic devices -- with potential for real-world applications May 25th, 2015

UCLA nanoscientists are first to model atomic structures of three bacterial nanomachines: Cryo electron microscope enables scientists to explore the frontiers of targeted antibiotics April 21st, 2015

Advances in molecular electronics: Lights on -- molecule on: Researchers from Dresden and Konstanz succeed in light-controlled molecule switching April 20th, 2015

Nanomedicine

Promising Step Taken in Iran towards Treatment of Spinal Cord Injury August 3rd, 2015

Diagnosis of Salmonella Bacterium-Caused Food Poisoning by Biosensors August 3rd, 2015

Gold-diamond nanodevice for hyperlocalised cancer therapy: Gold nanorods can be used as remote controlled nanoheaters delivering the right amount of thermal treatment to cancer cells, thanks to diamond nanocrystals used as temperature sensors August 1st, 2015

Heating and cooling with light leads to ultrafast DNA diagnostics July 31st, 2015

Discoveries

Promising Step Taken in Iran towards Treatment of Spinal Cord Injury August 3rd, 2015

Diagnosis of Salmonella Bacterium-Caused Food Poisoning by Biosensors August 3rd, 2015

Thin films offer promise for ferroelectric devices: Researchers at Tokyo Institute of Technology demystify the ferroelectric properties observed in hafnium-oxide-based thin films, revealing a potentially useful device material August 3rd, 2015

Self-assembling, biomimetic membranes may aid water filtration August 1st, 2015

Announcements

Promising Step Taken in Iran towards Treatment of Spinal Cord Injury August 3rd, 2015

Diagnosis of Salmonella Bacterium-Caused Food Poisoning by Biosensors August 3rd, 2015

Thin films offer promise for ferroelectric devices: Researchers at Tokyo Institute of Technology demystify the ferroelectric properties observed in hafnium-oxide-based thin films, revealing a potentially useful device material August 3rd, 2015

Advances and Applications in Biosensing, Sensor Power, and Sensor R&D to be Covered at Sensors Global Summit August 1st, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Promising Step Taken in Iran towards Treatment of Spinal Cord Injury August 3rd, 2015

Diagnosis of Salmonella Bacterium-Caused Food Poisoning by Biosensors August 3rd, 2015

Thin films offer promise for ferroelectric devices: Researchers at Tokyo Institute of Technology demystify the ferroelectric properties observed in hafnium-oxide-based thin films, revealing a potentially useful device material August 3rd, 2015

Self-assembling, biomimetic membranes may aid water filtration August 1st, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project