Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Chemistry breakthrough sheds new light on illness and health

Cells and tissue often outshine the contrast dyes used in medical imaging. A University of Copenhagen team of chemists have introduced a novel contrast dye that not only promises cleaner images, but also opens the door to motion pictures of what goes on inside cells.

Credit: University of Copenhagen/ Jes Andersen
Cells and tissue often outshine the contrast dyes used in medical imaging. A University of Copenhagen team of chemists have introduced a novel contrast dye that not only promises cleaner images, but also opens the door to motion pictures of what goes on inside cells.

Credit: University of Copenhagen/ Jes Andersen

Abstract:
From microscopes to MRI scanners, imaging technology is growing ever more vital in the world's hospitals, whether for the diagnosis of illness or for research into new cures. Imaging technology requires dyes or contrast agents of some sort. Current contrast agents and dyes are expensive, difficult to work with and far from ideal. Now, Danish chemists have discovered a new dye and proved its worth against any of the dyes currently available.

Chemistry breakthrough sheds new light on illness and health

Copenhagen, Denmark | Posted on May 12th, 2013

Thomas Just Sørensen and Bo Wegge Laursen are chemists at the University of Copenhagen, Denmark. In a series of publications in well-regarded scientific publications, they have shown that the aza-oxa-trangulenium dyes have the potential to outperform all fluorescent dyes currently used in imaging.

"Our dyes are ten times better, far cheaper and easier to use. The latter I believe, will lead to expanded opportunities and broadened use, by physicians and researchers in developing countries, for example." Says Thomas Just Sørensen.

Visual noise blocks correct diagnosis

It might seem odd, but one of the central challenges when taking pictures of cells and organs, is to avoid noise. The agents that make it possible to see microscopic biological structures are luminescent, but then, so is tissue. Consequently, the contrast agent's light risks being overpowered by "light noise". Just as the dial and hands of a watch might glow-in-the-dark, tissue becomes luminescent when exposed to light. Tissue and other organic structures luminesce, or lights up, for 10 nanoseconds after exposure to light. The light-life of an ordinary dye is the same - 10 nanoseconds. But triangulenium dyes produce light for an entire 100 nanoseconds.

The long life of the triangulenium dyes means that an image can be produced without background noise. Furthermore, the extra 90 nanoseconds opens the possibility of filming living images of the processes occurring within cells, for example when a drug attacks an illness.

Neither expensive, nor difficult or technically demanding

Medical image analysis departments currently devote an incredible amount of time to staining samples, because all samples must be treated with two agents. The use of triangulenium dyes necessitates only one dye. And in contrast with typical dyes, no specialized equipment is needed to see the dyes in tissue samples. A lens from a pair of polarized sunglasses and an ordinary microscope are all that are required.

Open Source dye despite obvious competitiveness

When one compares the advantages of triangulenium dyes against the three million Danish kroner per gram price tag of traditional dyes,(500.000$US)(320.000£) you would expect that the new dye would immediately out-compete its predecessors. However, up to now Sørensen and Laursen have had to give their dye away. "I know that our dye is better, but biologists and physicians don't. Therefore, we are giving the dye away to anyone that wants to perform a comparison test. Someone who needs to assess the health of sick people wouldn't dare to rely on an untested substance. Only when several researchers have shown triangulenium dyes to perform just as effectively as its predecessors can we hope for our substance to become more widely adopted," concludes Thomas Just Sørensen.

####

For more information, please click here

Contacts:
Jes Andersen

45-30-50-65-82

Copyright © University of Copenhagen

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

New TriboLab CMP Provides Cost-Effective Characterization of Chemical Mechanical Wafer Polishing Processes: Bruker Updates Industry-Standard CP-4 Platform for Most Flexible and Reliable Testing June 27th, 2017

Imaging

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Researchers developed nanoparticle based contrast agent for dual modal imaging of cancer June 21st, 2017

Cambridge Nanotherm partners with Inabata for global sales and distribution June 20th, 2017

Chemistry

Enhanced photocatalytic activity by Cu2O nanoparticles integrated H2Ti3O7 nanotubes June 21st, 2017

New carbon nitride material coupled with ruthenium enhances visible-light CO2 reduction in water June 15th, 2017

Discoveries

Physicists make quantum leap in understanding life's nanoscale machinery June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

Atomic imperfections move quantum communication network closer to reality June 25th, 2017

Research accelerates quest for quicker, longer-lasting electronics: UC Riverside-led research makes topological insulators magnetic well above room temperatures June 25th, 2017

Announcements

Bosch announces high-performance MEMS acceleration sensors for wearables June 27th, 2017

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

Picosun’s ALD solutions enable novel high-speed memories June 27th, 2017

Tools

Nanometrics to Participate in the 9th Annual CEO Investor Summit 2017: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2017 in San Francisco June 27th, 2017

NMRC, University of Nottingham chooses the Quorum Q150 coater for its reliable and reproducible film thickness when coating samples with iridium June 27th, 2017

New TriboLab CMP Provides Cost-Effective Characterization of Chemical Mechanical Wafer Polishing Processes: Bruker Updates Industry-Standard CP-4 Platform for Most Flexible and Reliable Testing June 27th, 2017

Researchers developed nanoparticle based contrast agent for dual modal imaging of cancer June 21st, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project