Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Chemistry breakthrough sheds new light on illness and health

Cells and tissue often outshine the contrast dyes used in medical imaging. A University of Copenhagen team of chemists have introduced a novel contrast dye that not only promises cleaner images, but also opens the door to motion pictures of what goes on inside cells.

Credit: University of Copenhagen/ Jes Andersen
Cells and tissue often outshine the contrast dyes used in medical imaging. A University of Copenhagen team of chemists have introduced a novel contrast dye that not only promises cleaner images, but also opens the door to motion pictures of what goes on inside cells.

Credit: University of Copenhagen/ Jes Andersen

Abstract:
From microscopes to MRI scanners, imaging technology is growing ever more vital in the world's hospitals, whether for the diagnosis of illness or for research into new cures. Imaging technology requires dyes or contrast agents of some sort. Current contrast agents and dyes are expensive, difficult to work with and far from ideal. Now, Danish chemists have discovered a new dye and proved its worth against any of the dyes currently available.

Chemistry breakthrough sheds new light on illness and health

Copenhagen, Denmark | Posted on May 12th, 2013

Thomas Just Sørensen and Bo Wegge Laursen are chemists at the University of Copenhagen, Denmark. In a series of publications in well-regarded scientific publications, they have shown that the aza-oxa-trangulenium dyes have the potential to outperform all fluorescent dyes currently used in imaging.

"Our dyes are ten times better, far cheaper and easier to use. The latter I believe, will lead to expanded opportunities and broadened use, by physicians and researchers in developing countries, for example." Says Thomas Just Sørensen.

Visual noise blocks correct diagnosis

It might seem odd, but one of the central challenges when taking pictures of cells and organs, is to avoid noise. The agents that make it possible to see microscopic biological structures are luminescent, but then, so is tissue. Consequently, the contrast agent's light risks being overpowered by "light noise". Just as the dial and hands of a watch might glow-in-the-dark, tissue becomes luminescent when exposed to light. Tissue and other organic structures luminesce, or lights up, for 10 nanoseconds after exposure to light. The light-life of an ordinary dye is the same - 10 nanoseconds. But triangulenium dyes produce light for an entire 100 nanoseconds.

The long life of the triangulenium dyes means that an image can be produced without background noise. Furthermore, the extra 90 nanoseconds opens the possibility of filming living images of the processes occurring within cells, for example when a drug attacks an illness.

Neither expensive, nor difficult or technically demanding

Medical image analysis departments currently devote an incredible amount of time to staining samples, because all samples must be treated with two agents. The use of triangulenium dyes necessitates only one dye. And in contrast with typical dyes, no specialized equipment is needed to see the dyes in tissue samples. A lens from a pair of polarized sunglasses and an ordinary microscope are all that are required.

Open Source dye despite obvious competitiveness

When one compares the advantages of triangulenium dyes against the three million Danish kroner per gram price tag of traditional dyes,(500.000$US)(320.000£) you would expect that the new dye would immediately out-compete its predecessors. However, up to now Sørensen and Laursen have had to give their dye away. "I know that our dye is better, but biologists and physicians don't. Therefore, we are giving the dye away to anyone that wants to perform a comparison test. Someone who needs to assess the health of sick people wouldn't dare to rely on an untested substance. Only when several researchers have shown triangulenium dyes to perform just as effectively as its predecessors can we hope for our substance to become more widely adopted," concludes Thomas Just Sørensen.

####

For more information, please click here

Contacts:
Jes Andersen

45-30-50-65-82

Copyright © University of Copenhagen

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Chemistry

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Imaging

National Synchrotron Light Source II Achieves 'First Light' October 23rd, 2014

News and information

Novel Rocket Design Flight Tested: New Rocket Propellant and Motor Design Offers High Performance and Safety October 23rd, 2014

MEMS & Sensors Technology Showcase: Finalists Announced for MEMS Executive Congress US 2014 October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Discoveries

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Announcements

Nanoparticle technology triples the production of biogas October 23rd, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Advancing thin film research with nanostructured AZO: Innovnano’s unique and cost-effective AZO sputtering targets for the production of transparent conducting oxides October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Tools

National Synchrotron Light Source II Achieves 'First Light' October 23rd, 2014

Advancing thin film research with nanostructured AZO: Innovnano’s unique and cost-effective AZO sputtering targets for the production of transparent conducting oxides October 23rd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE