Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Dark field imaging of rattle-type silica nanorattles coated gold nanoparticles in vitro and in vivo

SN @ GNs showed dark field imaging function of cell and animal tissue and significantly improved the biocompatibility of gold nanoparticles.

Credit: ©Science China Press
SN @ GNs showed dark field imaging function of cell and animal tissue and significantly improved the biocompatibility of gold nanoparticles.

Credit: ©Science China Press

Abstract:
In recent years, metal nanoparticles have showed great application prospect in the field of biological imaging, cancer diagnosis and treatment due to its unique optical scattering and optical absorption properties. In many metal materials, gold nanoparticles have caused concerns in the field because of its simple preparation, easy to modify advantages. However, the poor stability in physiological fluids environment and the potential toxicity of gold nanoparticles always restricts its application in the biological field.

Dark field imaging of rattle-type silica nanorattles coated gold nanoparticles in vitro and in vivo

China | Posted on April 29th, 2013

TANG Fangqiong and her group from Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences have been devoted to the controllable preparation of nanomaterials and biological applications. In recent years, they invented a method to fabricate silica nanoparticles with the special rattles-type structure named silica nanorattles (SNs) and developed the nanoparticles as drug delivery system, biological detection and catalytic. Their work, entitled "Dark field imaging of rattle-type silica nanorattles coated gold nanoparticles in vitro and in vivo", was published in Chinese Science Bulletin 2013, Vol 58(7).

In this paper, the gold nanoparticles were ingeniously hybridized into the hollow cavity of silica nanorattles. Then, a new type silica nanorattles coated gold nanoparticles (Silica nanorattles @ gold nanoparticles, SN @ GNs) was obtained. It has advantage as following, scale preparation, good stability in the physiological environment and reduce gold nanoparticles agglomeration. These particles remained the strong optical scattering of gold nanoparticles and plasma resonance properties which can be used in dark field imaging of cells and animal tissues in vivo (figure 1). And more important is the silica nanoshells significantly reduced the toxicity of gold nanoparticles in vivo, which increase the maximum tolerated dose to 200 mg/kg.

Above all, TANG group have developed a new type of composite nanoparticles combination of silica good biocompatibility and the optical properties of gold nanoparticles. It provides a new material and method for the application of nanomaterials in biological imaging and disease diagnosis. This research project was partially supported by a grant from the National High Technology Research and Development Program (2011 AA02A114) and the National Natural Science Foundation of China (61178035, 61178035 and 61171049).

####

About Science China Press
Science China Press Co., Ltd. (SCP) is a scientific journal publishing company of the Chinese Academy of Sciences (CAS). For 50 years, SCP takes its mission to present to the world the best achievements by Chinese scientists on various fields of natural sciences researches.

For more information, please click here

Contacts:
Corresponding author:

Tang Fangqiong


Copyright © Science China Press

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

See the article: LIU TianLong, TAN LongFei, TANG Fangqiong et al. Dark field imaging of rattle-type silica nanorattles coated gold nanoparticles in vitro and in vivo[J]. Chinese Science Bulletin, 2013, 58(7): 531-536

Related News Press

News and information

Texas A&M Chemist Says Trapped Electrons To Blame For Lack Of Battery Efficiency: Forget mousetraps — today’s scientists will get the cheese if they manage to build a better battery June 28th, 2016

Building a smart cardiac patch: 'Bionic' cardiac patch could one day monitor and respond to cardiac problems June 28th, 2016

New, better way to build circuits for world's first useful quantum computers June 28th, 2016

Yale researchers’ technology turns wasted heat into power June 27th, 2016

Imaging

Texas A&M Chemist Says Trapped Electrons To Blame For Lack Of Battery Efficiency: Forget mousetraps — today’s scientists will get the cheese if they manage to build a better battery June 28th, 2016

Discoveries

Texas A&M Chemist Says Trapped Electrons To Blame For Lack Of Battery Efficiency: Forget mousetraps — today’s scientists will get the cheese if they manage to build a better battery June 28th, 2016

Building a smart cardiac patch: 'Bionic' cardiac patch could one day monitor and respond to cardiac problems June 28th, 2016

New, better way to build circuits for world's first useful quantum computers June 28th, 2016

Yale researchers’ technology turns wasted heat into power June 27th, 2016

Announcements

Texas A&M Chemist Says Trapped Electrons To Blame For Lack Of Battery Efficiency: Forget mousetraps — today’s scientists will get the cheese if they manage to build a better battery June 28th, 2016

Building a smart cardiac patch: 'Bionic' cardiac patch could one day monitor and respond to cardiac problems June 28th, 2016

New, better way to build circuits for world's first useful quantum computers June 28th, 2016

Yale researchers’ technology turns wasted heat into power June 27th, 2016

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Texas A&M Chemist Says Trapped Electrons To Blame For Lack Of Battery Efficiency: Forget mousetraps — today’s scientists will get the cheese if they manage to build a better battery June 28th, 2016

Building a smart cardiac patch: 'Bionic' cardiac patch could one day monitor and respond to cardiac problems June 28th, 2016

New, better way to build circuits for world's first useful quantum computers June 28th, 2016

Yale researchers’ technology turns wasted heat into power June 27th, 2016

Tools

Texas A&M Chemist Says Trapped Electrons To Blame For Lack Of Battery Efficiency: Forget mousetraps — today’s scientists will get the cheese if they manage to build a better battery June 28th, 2016

FEI Launches Helios G4 DualBeam Series for Materials Science: The Helios G4 DualBeam Series features new capabilities to enable scientists and engineers to answer the most demanding and challenging scientific questions June 27th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Ultrathin, flat lens resolves chirality and color: Multifunctional lens could replace bulky, expensive machines June 25th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic