Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Scientists image nanoparticles in action

Deborah Kelly
Deborah Kelly

Abstract:
The macroscopic effects of certain nanoparticles on human health have long been clear to the naked eye. What scientists have lacked is the ability to see the detailed movements of individual particles that give rise to those effects.



For the first time, researchers at the Virginia Tech Carilion Research Institute have imaged nanoparticles in action in a liquid environment.

Scientists image nanoparticles in action

Roanoke, VA | Posted on April 25th, 2013

In a recently published study, scientists at the Virginia Tech Carilion Research Institute invented a technique for imaging nanoparticle dynamics with atomic resolution as these dynamics occur in a liquid environment. The results will allow, for the first time, the imaging of nanoscale processes, such as the engulfment of nanoparticles into cells.

"We were stunned to see the large-ranged mobility in such small objects," said Deborah Kelly, an assistant professor at the Virginia Tech Carilion Research Institute. "We now have a system to watch the behaviors of therapeutic nanoparticles at atomic resolution."

Nanoparticles are made of many materials and come in different shapes and sizes. In the new study, Kelly and her colleagues chose to make rod-shaped gold nanoparticles the stars of their new molecular movies. These nanoparticles, roughly the size of a virus, are used to treat various forms of cancer. Once injected, they accumulate in solid tumors. Infrared radiation is then used to heat them and destroy nearby cancerous cells.

To take an up-close look at the gold nanoparticles in action, the researchers made a vacuum-tight microfluidic chamber by pressing two silicon-nitride semiconductor chips together with a 150-nanometer spacer in between. The microchips contained transparent windows so the beam from a transmission electron microscope could pass through to create an atomic-scale image.

Using the new technique, the scientists created two types of visualizations. The first included pictures of individual nanoparticles' atomic structures at 100,000-times magnification - the highest resolution images ever taken of nanoparticles in a liquid environment.

The second visualization was a movie captured at 23,000-times magnification that revealed the movements of a group of nanoparticles reacting to an electron beam, which mimics the effects of the infrared radiation used in cancer therapies.

In the movie, the gold nanoparticles can be seen surfing nanoscale tidal waves.

"The nanoparticles behaved like grains of sand being concentrated on a beach by crashing waves," said Kelly. "We think this behavior may be related to why the nanoparticles become concentrated in tumors. Our next experiment will be to insert a cancer cell to study the nanoparticles' therapeutic effects on tumors."

The team is also testing the resolution of the microfluidic system with other reagents and materials, bringing researchers one step closer to viewing live biological mechanisms in action at the highest levels of resolution possible.

The study appeared in Chemical Communications in the article "Visualizing Nanoparticle Mobility in Liquid at Atomic Resolution," by Madeline Dukes, an applications scientist at Protochips Inc. in Raleigh, N.C.; Benjamin Jacobs, an applications scientist at Protochips; David Morgan, assistant manager of the Cryo-Transmission Electron Microscopy Facility at Indiana University Bloomington; Harshad Hegde, a computer scientist at the Virginia Tech Carilion Research Institute; and Kelly, who is also an assistant professor of biological sciences in the College of Science at Virginia Tech.

The Virginia Tech Carilion School of Medicine and Research Institute joins the basic science, life science, bioinformatics, and engineering strengths of Virginia Tech with the medical practice and medical education experience of Carilion Clinic. Virginia Tech Carilion is located in a new biomedical health sciences campus in Roanoke at 2 Riverside Circle.

Written by Ken Kingery.

####

For more information, please click here

Contacts:
Paula Byron

540-526-2027

Copyright © Virginia Tech

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Article - “Visualizing Nanoparticle Mobility in Liquid at Atomic Resolution,” by Madeline Duke:

Related News Press

News and information

Iranian Researchers Synthesize Stable Ceramic Nanopowders at Room Temperature September 20th, 2014

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

Imaging

IEEE International Electron Devices Meeting To Celebrate 60th Anniversary as The Leading Technical Conference for Advanced Semiconductor Devices September 18th, 2014

FEI Opens New Technology Center in Czech Republic: FEI expands its presence in Brno with the opening of a new, larger facility September 18th, 2014

New NPZ100-403 Piezo Stage from nPoint Inc. September 17th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Development of Algorithm for Accurate Calculation of Average Distance Travelled by Low-Speed Electrons without Energy Loss that Are Sensitive to Surface Structure September 11th, 2014

Microfluidics/Nanofluidics

Dolomite to launch Meros TCU-100 temperature controller at Lab-on-a-Chip & Microarray World Congress September 15th, 2014

First Colloid and Polymer Science Lecture awarded to Orlin D. Velev: Chemical engineer honored for outstanding research in colloid science September 12th, 2014

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique: Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets September 2nd, 2014

Nanomedicine

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

The Pocket Project will develop a low-cost and accurate point-of-care test to diagnose Tuberculosis: ICN2 holds a follow-up meeting of the Project on September 18th - 19th September 18th, 2014

New non-invasive technique could revolutionize the imaging of metastatic cancer September 17th, 2014

Recruiting bacteria to be technology innovation partners: September 17th, 2014

Discoveries

Iranian Scientists Separate Zinc Ion at Low Concentrations September 20th, 2014

Iranian Researchers Synthesize Stable Ceramic Nanopowders at Room Temperature September 20th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

New research points to graphene as a flexible, low-cost touchscreen solution September 19th, 2014

Announcements

Iranian Scientists Separate Zinc Ion at Low Concentrations September 20th, 2014

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

SouthWest NanoTechnologies (SWeNT) Receives NIST Small Business Innovation Research (SBIR) Phase 1 Award to Produce Greater than 99% Semiconducting Single-Wall Carbon Nanotubes September 19th, 2014

Toward optical chips: A promising light source for optoelectronic chips can be tuned to different frequencies September 19th, 2014

Tools

IEEE International Electron Devices Meeting To Celebrate 60th Anniversary as The Leading Technical Conference for Advanced Semiconductor Devices September 18th, 2014

FEI Opens New Technology Center in Czech Republic: FEI expands its presence in Brno with the opening of a new, larger facility September 18th, 2014

New NPZ100-403 Piezo Stage from nPoint Inc. September 17th, 2014

Researchers Create World’s Largest DNA Origami September 11th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE