Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Breakthrough in chemical crystallography

Abstract:
A research team led by Professor Makoto Fujita of the University of Tokyo, Japan, and complemented by Academy Professor Kari Rissanen of the University of Jyväskylä, Finland, has made a fundamental breakthrough in single-crystal X-ray analysis, the most powerful method for molecular structure determination. The team's breakthrough was reported in Nature on 28 March 2013 (published online 27 March 2013).

Breakthrough in chemical crystallography

Helsinki, Finland | Posted on April 8th, 2013

X-ray single-crystal diffraction (SCD) analysis has the intrinsic limitation that the target molecule must be obtained as single crystals. Now, Professor Fujita's team at the University of Tokyo together with Academy Professor Rissanen at the University of Jyväskylä have established a new protocol for SCD analysis that does not require the crystallisation of the target molecule. In this method, a very small crystal of a porous complex absorbs the target molecule from the solution, enabling the crystallographic analysis of the structure of the absorbed guest along with the host framework.

As the SCD analysis is carried out with only one crystal, smaller than 0.1 x 0.1 x 0.1 mm in size, the required amount of the target molecule can be as low as 80 ng. Fujita's and Rissanen's work reports the structure determination of a scarce marine natural product from only 5 µg of it. Many natural and synthetic compounds for which chemists have almost given up the hope of analysing crystallographically can now be easily and precisely characterised by this method.

Full bibliographic information

article: Nature 495, pp. 461-466 (28 March 2013), DOI:10.1038/nature11990, published online 27 March 2013

####

About Suomen Akatemia (Academy of Finland)
The Academy of Finland’s mission is to finance high-quality scientific research, act as a science and science policy expert, and strengthen the position of science and research.

The Academy works to contribute to the renewal, diversification and increasing internationalisation of Finnish research. Its operation covers the full spectrum of scientific disciplines.

The Academy supports and facilitates researcher training and careers in research, internationalisation as well as the practical application of research results. The Academy is keen to emphasise the importance of the impact of research and breakthrough research by encouraging researchers to submit boundary-crossing funding plans that involve risks but that also offer promise and potential for scientifically significant breakthroughs.

The Academy funds research annually with 327 million euros (year 2012). Each year the Academy receives funding applications worth 1.1 billion euros. Funding is provided for research projects, research programmes, Centres of Excellence in research, research posts, foreign visiting professors’ work in Finland, researcher training, international networking and research collaboration between universities, research institutes and business companies. Each year Academy-funded projects account for some 3,000 researcher FTEs at universities and research institutes.

For more information, please click here

Contacts:
Anita Westerback
+358 29 533 5132


method and applications:
Professor Makoto Fujita
University of Tokyo


crystallographic aspects:
Academy Professor Kari Rissanen
University of Jyväskylä

tel. +358 50 562 3721

Copyright © AlphaGalileo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

NanoSummit in Luxembourg: single wall carbon nanotubes have entered our lives as we approach a nanoaugmented future November 23rd, 2017

JPK reports on the exciting research in the School of Medicine at Sungkyunkwan University (SKKU), Suwon, South Korea using the NanoWizard® ULTRA Speed AFM to understand the binding of transcription factor Sox2 with super enhancers November 23rd, 2017

Precision NanoSystems to host nanomedicines roundtable November 23rd, 2017

Fine felted nanotubes : Research team of Kiel University develops new composite material made of carbon nanotubes November 22nd, 2017

Imaging

JPK reports on the exciting research in the School of Medicine at Sungkyunkwan University (SKKU), Suwon, South Korea using the NanoWizard® ULTRA Speed AFM to understand the binding of transcription factor Sox2 with super enhancers November 23rd, 2017

Discoveries

Fine felted nanotubes : Research team of Kiel University develops new composite material made of carbon nanotubes November 22nd, 2017

Quantum optics allows us to abandon expensive lasers in spectroscopy: Lomonosov Moscow State University scientists have invented a new method of spectroscopy November 21st, 2017

Nano-watch has steady hands November 21st, 2017

Nanoparticles could allow for faster, better medicine: Exposure of nanoparticles in the body allows for more effective delivery November 20th, 2017

Announcements

NanoSummit in Luxembourg: single wall carbon nanotubes have entered our lives as we approach a nanoaugmented future November 23rd, 2017

JPK reports on the exciting research in the School of Medicine at Sungkyunkwan University (SKKU), Suwon, South Korea using the NanoWizard® ULTRA Speed AFM to understand the binding of transcription factor Sox2 with super enhancers November 23rd, 2017

Precision NanoSystems to host nanomedicines roundtable November 23rd, 2017

Fine felted nanotubes : Research team of Kiel University develops new composite material made of carbon nanotubes November 22nd, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project