Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > FEI Unveils Broad Correlative Microscopy Solution Set for Cell Biologists: By combining imaging techniques and efficient workflows, cell biologists could gain a better understanding of the structure and function of cells to improve the treatment of disease

Abstract:
FEI (NASDAQ: FEIC) today announced a suite of solutions for correlative light and electron microscopy (CLEM). New methods in correlative microscopy from FEI bring data from different imaging techniques together automatically in minutes, giving cell biologists the precise information they need, when they need it. Scientists believe that correlating information from the cellular down to the molecular level will lead to breakthrough discoveries that improve their understanding and treatment of diseases, such as cancer, AIDS, and Parkinson's.

FEI Unveils Broad Correlative Microscopy Solution Set for Cell Biologists: By combining imaging techniques and efficient workflows, cell biologists could gain a better understanding of the structure and function of cells to improve the treatment of disease

Hillsboro, OR | Posted on November 26th, 2012

"Light microscopy encompasses a broad and varied set of techniques and methodologies, each with its own requirements for correlation. One workflow does not fit all," said Dominique Hubert, vice president and general manager of FEI's Life Sciences Business Unit. "We have developed a set of workflows that are flexible enough to cover a significant share of the possible applications. And we are committed to extending that coverage as the science develops."

Electron microscopy (EM) offers extremely high image resolution—1,000 or more times better than light microscopes. Light microscopes (LM) offer a wide variety of specialized techniques, such as fluorescent labeling, that can identify a single molecule or structure within a large, complex environment like the interior of a living cell. Correlating between the two techniques allows scientists to use LM to find the target and EM to explore its form and function. Correlative microscopy allows investigators to find a feature of interest faster in the EM, gain additional information about its structure down to the molecular scale, and understand relationships between the feature and its larger scale context.

The correlative microscopy solution set from FEI includes:

· Tecnai™ with iCorr™—a fully-integrated workflow in which the light microscope is incorporated into a transmission electron microscope (TEM) column.

· CorrSight™— an advanced light microscope dedicated to the different steps of correlative experiments, enabling researchers to image live cell dynamics and quickly fix those cells for EM.

· MAPS—a software solution that allows correlation between the electron microscope image and an image from any other source through a simple alignment procedure.

Oregon Health and Science University's Professor Joe Gray, based in Portland, Ore., states, "Biologists want to understand the molecular events and interactions that constitute the larger scale processes we observe in cells and tissues. This will require integration of information from multiple resolution scales, for example, ultrastructural analysis of cells that reside in specific microenvironmental niches. The iCorr system allows us to quickly find fluorescently stained cells of interest using fluorescence microscopy and followed by detailed structural analysis using electron microscopy."

Roger Wepf, director of electron microscopy at the Swiss Federal Institute of Technology in Zurich (ETH Zurich) adds, "With CorrSight, sample preparation for the electron microscope is integrated with the light microscope, using on-board fixation. We identify the target structure and prepare the sample on the CorrSight light microscope platform, then transfer the sample to the electron microscope and, with a few clicks of the mouse, navigate directly the target. This is exactly what we have been missing since it allows us to reduce manual, tedious work and improve reproducibility. CorrSight and MAPS will open new applications in correlative microscopy that were not possible before."

Hubert added, "At this point, we have only glimpsed the potential of correlative microscopy. It promises to open whole new avenues of investigation into the relationships between structure and function in biological systems at the finest scale. FEI is committed to leading the expansion of this applications space by developing correlative workflow solutions for the broadest range of techniques and methodologies."

For more information about the correlative solution set from FEI, please see www.fei.com/correlative-microscopy. For a demonstration of the Tecnai with iCorr, please go to http://fei.com/tecnai_icorr. Or visit FEI at the American Society for Cell Biology Annual Meeting, December 15-19, 2012, San Francisco, Calif., booth 513.

####

About FEI Company
FEI (Nasdaq: FEIC) is a leading diversified scientific instruments company. It is a premier provider of electron- and ion-beam microscopes and solutions for nanoscale applications across many industries: industrial and academic materials research, life sciences, semiconductors, data storage, natural resources and more. With more than 60 years of technological innovation and leadership, FEI has set the performance standard in transmission electron microscopes (TEM), scanning electron microscopes (SEM) and DualBeams™, which combine a SEM with a focused ion beam (FIB). Headquartered in Hillsboro, Ore., USA, FEI has over 2,300 employees and sales and service operations in more than 50 countries around the world. More information can be found at: www.fei.com.

FEI Safe Harbor Statement

This news release contains forward-looking statements that include statements regarding the performance capabilities and benefits of FEI’s correlative solution set: Tecnai with iCorr, CorrSight, and MAPS. Factors that could affect these forward-looking statements include but are not limited to failure of the product or technology to perform as expected and achieve anticipated results, unexpected technology problems and challenges, changes to the technology, the inability of FEI, its suppliers or project partners to make the technological advances required for the technology to achieve anticipated results, the inability of customers to develop and deploy the expected new applications and our ability to manufacture, ship and deliver the tools or software as expected. Please also refer to our Form 10-K, Forms 10-Q, Forms 8-K and other filings with the U.S. Securities and Exchange Commission for additional information on these factors and other factors that could cause actual results to differ materially from the forward-looking statements. FEI assumes no duty to update forward-looking statemen

For more information, please click here

Contacts:
Sandy Fewkes
(media contact)
MindWrite Communications, Inc
+1 408 224 4024


FEI
Fletcher Chamberlin
(investors and analysts)
Investor Relations
+1 503 726 7710

Copyright © FEI Company

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanobiotix: The Independent Data Monitoring Committee Recommends the Continuation of the Ongoing Phase II/III Trial of NBTXR3 in Soft Tissue Sarcoma March 23rd, 2017

Leti Presents Advances in Propagation Modeling and Antenna Design for mmWave Spectrum: Paper Is One of 15 that Leti Presented at European Conference on Antennas and Propagation March 19-24 March 23rd, 2017

Rice U. refines filters for greener natural gas: New study defines best materials for carbon capture, methane selectivity March 23rd, 2017

Artificial photosynthesis steps into the light: Rice University lab turns transition metals into practical catalyst for solar, other applications March 23rd, 2017

Imaging

Caught on camera -- chemical reactions 'filmed' at the single-molecule level March 22nd, 2017

Next-gen steel under the microscope March 18th, 2017

Novel nozzle saves crystals: Double flow concept widens spectrum for protein crystallography March 17th, 2017

JPK’s NanoWizard® AFM systems are used at the University of Sheffield to understand soft matter and biological systems at the molecular scale March 7th, 2017

Nanomedicine

Nanobiotix: The Independent Data Monitoring Committee Recommends the Continuation of the Ongoing Phase II/III Trial of NBTXR3 in Soft Tissue Sarcoma March 23rd, 2017

Nanoparticle paves the way for new triple negative breast cancer drug March 20th, 2017

Block copolymer micellization as a protection strategy for DNA origami March 17th, 2017

Nanocages for gold particles: what is happening inside? March 16th, 2017

Announcements

Nanobiotix: The Independent Data Monitoring Committee Recommends the Continuation of the Ongoing Phase II/III Trial of NBTXR3 in Soft Tissue Sarcoma March 23rd, 2017

Leti Presents Advances in Propagation Modeling and Antenna Design for mmWave Spectrum: Paper Is One of 15 that Leti Presented at European Conference on Antennas and Propagation March 19-24 March 23rd, 2017

Rice U. refines filters for greener natural gas: New study defines best materials for carbon capture, methane selectivity March 23rd, 2017

Artificial photosynthesis steps into the light: Rice University lab turns transition metals into practical catalyst for solar, other applications March 23rd, 2017

Tools

Caught on camera -- chemical reactions 'filmed' at the single-molecule level March 22nd, 2017

CRMGroup in Belgium uses a Deben three point bending stage in the development of new steel & coated steel products for automotive and other industrial applications March 21st, 2017

Next-gen steel under the microscope March 18th, 2017

Novel nozzle saves crystals: Double flow concept widens spectrum for protein crystallography March 17th, 2017

Events/Classes

Leti Presents Advances in Propagation Modeling and Antenna Design for mmWave Spectrum: Paper Is One of 15 that Leti Presented at European Conference on Antennas and Propagation March 19-24 March 23rd, 2017

Next-gen steel under the microscope March 18th, 2017

UC researchers use gold coating to control luminescence of nanowires: University of Cincinnati physicists manipulate nanowire semiconductors in pursuit of making electronics smaller, faster and cheaper March 17th, 2017

Harris & Harris Group Issues Its Financial Statements as of December 31, 2016, Posts Its Annual Shareholder Letter, And Will Host a Conference Call for Shareholders on Friday, March 17, 2017 March 15th, 2017

Nanobiotechnology

Nanobiotix: The Independent Data Monitoring Committee Recommends the Continuation of the Ongoing Phase II/III Trial of NBTXR3 in Soft Tissue Sarcoma March 23rd, 2017

Nanoparticle paves the way for new triple negative breast cancer drug March 20th, 2017

Block copolymer micellization as a protection strategy for DNA origami March 17th, 2017

Nanocages for gold particles: what is happening inside? March 16th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project