Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Stain Your Brain: Nanoparticles Enable Brain Surgery

Image: dream designs / FreeDigitalPhotos.net
Image: dream designs / FreeDigitalPhotos.net

Abstract:
by Adrian Miller

Brain surgery is hard. Proverbially hard, in fact (writing this article might need a bit of thought, but, you know, it's not brain surgery). One of the most difficult parts for operating surgeons is distinguishing the tumorous growth from healthy brain tissue - the more precisely delineated the tumor is, the better the chances for a successful operation and recovery. Now, researchers have announced new work on a new system, using dye-loading nanoparticles, which could have a major impact on the success of brain surgery.

Stain Your Brain: Nanoparticles Enable Brain Surgery

Germany | Posted on January 20th, 2012

The most common current method to delineate between tumor and brain tissue is to use images of the brain taken before the operation begins - while this helps to guide the operating surgeon (who can also call on their ability to distinguish the tumor on sight), cancerous tissue can be completely indistinguishable from healthy brain tissue.

Early efforts to improve this basic method include the use of imaging systems during the surgery - which can distract the surgeon from the task at hand, by splitting their attention between the monitor and the patient, and which also call for high-cost, complex equipment - and the use of fluorescence tagging of brain tumors, raising the terrifying possibility of doctors performing this complex operation in the dark!

That's where Professor Raol Kopelman's University of Michigan research team come in - deciding that these current methods just won't cut it, they've developed a new system that uses dye-loaded nanoparticles to tag brain tumors for removal.

The Michigan team's system is designed to avoid the pitfalls of both these approaches - the use of a visible-light dye means no special detection equipment or lighting conditions are necessary. However, it is not without its own pitfalls - when the team published their initial findings in 2009, they reported one major problem that potentially made in vivo application impossible. The nanoparticles were loaded with dye in such a way that they produced too much non-specific staining - they just wouldn't show the tumor clearly enough.

Move forward three years, and things are looking much more promising; the combination of a new, covalently linkable dye derivative, a better nanoparticle synthesis procedure, and the introduction of PEG crosslinkers to improve stability in blood have resulted in a fair more stable system. Tests, both in vitro and in vivo, found no dye leaching, and tumors remain stained for long periods of time. One suspects that, although there may be some stops along the way, the final destination of this method will be the operating theater.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

R. Kopelman et al., Small ; DOI: 10.1002/smll.201101607

Related News Press

News and information

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

National Space Society Welcomes Janet Ivey As New NSS Governor: Janet Ivey of Janet's Planet is NOW IN ORBIT as a member of the Board of Governors of the National Space Society August 27th, 2015

Imaging

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

50 Years of Scanning Electron Microscopy from ZEISS: ZEISS celebrates the birth of the first commercial scanning electron microscope in 1965 August 26th, 2015

Announcing Oxford Instruments and School of Physics signing a Memorandum of Understanding August 26th, 2015

Nanomedicine

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Glitter from silver lights up Alzheimer's dark secrets August 25th, 2015

Discoveries

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

CWRU researchers efficiently charge a lithium-ion battery with solar cell: Coupling with perovskite solar cell holds potential for cleaner cars and more August 27th, 2015

Successful boron-doping of graphene nanoribbon August 27th, 2015

Announcements

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

A new technique to make drugs more soluble August 28th, 2015

CWRU researchers efficiently charge a lithium-ion battery with solar cell: Coupling with perovskite solar cell holds potential for cleaner cars and more August 27th, 2015

Successful boron-doping of graphene nanoribbon August 27th, 2015

Researchers combine disciplines, computational programs to determine atomic structure August 26th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic