Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Stain Your Brain: Nanoparticles Enable Brain Surgery

Image: dream designs / FreeDigitalPhotos.net
Image: dream designs / FreeDigitalPhotos.net

Abstract:
by Adrian Miller

Brain surgery is hard. Proverbially hard, in fact (writing this article might need a bit of thought, but, you know, it's not brain surgery). One of the most difficult parts for operating surgeons is distinguishing the tumorous growth from healthy brain tissue - the more precisely delineated the tumor is, the better the chances for a successful operation and recovery. Now, researchers have announced new work on a new system, using dye-loading nanoparticles, which could have a major impact on the success of brain surgery.

Stain Your Brain: Nanoparticles Enable Brain Surgery

Germany | Posted on January 20th, 2012

The most common current method to delineate between tumor and brain tissue is to use images of the brain taken before the operation begins - while this helps to guide the operating surgeon (who can also call on their ability to distinguish the tumor on sight), cancerous tissue can be completely indistinguishable from healthy brain tissue.

Early efforts to improve this basic method include the use of imaging systems during the surgery - which can distract the surgeon from the task at hand, by splitting their attention between the monitor and the patient, and which also call for high-cost, complex equipment - and the use of fluorescence tagging of brain tumors, raising the terrifying possibility of doctors performing this complex operation in the dark!

That's where Professor Raol Kopelman's University of Michigan research team come in - deciding that these current methods just won't cut it, they've developed a new system that uses dye-loaded nanoparticles to tag brain tumors for removal.

The Michigan team's system is designed to avoid the pitfalls of both these approaches - the use of a visible-light dye means no special detection equipment or lighting conditions are necessary. However, it is not without its own pitfalls - when the team published their initial findings in 2009, they reported one major problem that potentially made in vivo application impossible. The nanoparticles were loaded with dye in such a way that they produced too much non-specific staining - they just wouldn't show the tumor clearly enough.

Move forward three years, and things are looking much more promising; the combination of a new, covalently linkable dye derivative, a better nanoparticle synthesis procedure, and the introduction of PEG crosslinkers to improve stability in blood have resulted in a fair more stable system. Tests, both in vitro and in vivo, found no dye leaching, and tumors remain stained for long periods of time. One suspects that, although there may be some stops along the way, the final destination of this method will be the operating theater.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

R. Kopelman et al., Small ; DOI: 10.1002/smll.201101607

Related News Press

News and information

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

SUNY Polytechnic Institute Invites the Public to Attend its Popular Statewide 'NANOvember' Series of Outreach and Educational Events October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Imaging

National Synchrotron Light Source II Achieves 'First Light' October 23rd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Nanomedicine

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

RF Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials October 23rd, 2014

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Discoveries

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Nanoparticle technology triples the production of biogas October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Announcements

Iran to Hold 3rd Int'l Engineering Materials, Metallurgy Conference October 25th, 2014

Haydale Secures Exclusive Development and Supply Agreement with Tantec A/S: New reactors to be built and commissioned by Tantec A/S represent another step forward towards the commercialisation of graphene October 24th, 2014

QuantumWise guides the semiconductor industry towards the atomic scale October 24th, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

Iranian Scientists Apply Nanotechnology to Produce Surgery Suture October 23rd, 2014

Iranian, Malaysian Scientists Study Nanophotocatalysts for Water Purification October 23rd, 2014

Strengthening thin-film bonds with ultrafast data collection October 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE