Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Made to measure viral drug delivery: Malvern’s Zetasizer Nano proves to be the perfect instrument for a student environment

Abstract:
While viruses are so often seen as the enemy, modern scientific techniques may soon be able to harness the strengths of a virus for drug delivery systems that are designed to treat diseases, rather than cause them. Using a Zetasizer Nano particle characterization system from Malvern Instruments, researchers at Indiana University's (IU) Molecular and Cellular Biochemistry Department have been studying self-assembled virus-based drug delivery systems that can be tuned to a particular size enabling the uptake of specific functional cargo.

Made to measure viral drug delivery: Malvern’s Zetasizer Nano proves to be the perfect instrument for a student environment

Malvern, UK | Posted on April 6th, 2011

Dr Stella Aniagyei, post doctoral research associate at the IU's Molecular and Cellular Biochemistry department explains: "Viruses tend to be nanosized, symmetrical and structurally consistent with a narrow size distribution. Despite this apparent biological simplicity, viruses are extremely good at delivering their own genome to living biological tissue. This makes them a prime target for biological engineers looking for an efficient transportation device that will deliver drug directly to infected cells."

"Here at IU's Nanocharacterization facility, the Malvern Zetasizer Nano is the ‘go to' instrument for characterization of assembled product," said Dr Aniagyei. "Structures closely resembling virus give a narrow size distribution. If they don't, then we know the process has gone off the biological path. We are currently looking at aggregation limits to move towards defining optimum ionic conditions for the assembly of nucleic acid binding to Gag proteins [one of the nine genes in the retrovirus RNA genome]."

Malvern's Zetasizer range uses light scattering techniques to measure hydrodynamic size, zeta potential and molecular weight of proteins and nanoparticles. According to Dr Aniagyei, "Malvern's Zetasizer Nano is very useful for protein characterization. The ease with which it can be used makes it the perfect instrument for the student environment. It definitely is one of the easiest instruments I've had to work with."

Indiana University (IU) is already in the spotlight having just received $900,000 from the Ovarian Cancer Research Fund, or OCRF, to help them prepare the new drug SGI-110 for clinical trials in patients whose once-thwarted ovarian cancer has returned. However, this work is not the only IU project at the cutting edge. Established on July 1 2009, the Department of Molecular and Cellular Biochemistry was the first science department created on the Indiana University Bloomington campus in 33 years. Linking biology, chemistry, and medical sciences, the department's main focus is on the priority areas of structural virology and virus assembly.

For more details about the Zetasizer Nano go to www.malvern.com/zetasizer

For more about the work of Indiana University's Molecular and Cellular Biochemistry department visit www.indiana.edu/~mcbdept

Malvern, Malvern Instruments and Zetasizer are registered trademarks of Malvern Instruments Ltd

####

About Malvern Instruments
Malvern Instruments is a market leader in measuring performance controlling material properties. These include particle size, particle shape, zeta potential, molecular weight, size and conformation, rheological properties and chemical distribution. Malvern delivers the systems, support and expertise that ensure the analytical integrity and productivity needed to drive research, development and manufacturing.

Malvern’s measurement solutions for scientists, technologists and engineers advance continually through customer collaboration. Complementary materials characterization systems deliver inter-related measurements that reflect the complexities of particulates and disperse systems, nanomaterials and macromolecules. Combining intelligently implemented technologies with in-depth industry applications knowledge and support, Malvern provides customers with the competitive advantage they demand.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Korea and Japan, a joint venture in India, a global distributor network and applications laboratories around the world.

For more information, please click here

Contacts:
For press information, please contact:
Trish Appleton
Kapler Communications Knowledge Centre, Wyboston Lakes, Great North Road
Wyboston, Bedfordshire, MK44 3BY, UK
Tel: +44 (0)1480 479280
Fax: +44 (0)1480 470343


USA contact:
Marisa Fraser
Malvern Instruments Inc.
117 Flanders Road
Westborough, MA 01581-1042 USA
Tel: +1 508 768 6400
Fax: +1 508 768 6403


Please send sales enquiries to:
Alison Vines
Malvern Instruments Ltd
Enigma Business Park, Grovewood Road
Malvern, Worcestershire WR14 1XZ UK
Tel: +44 (0) 1684 892456
Fax: +44 (0) 1684 892789

Copyright © Malvern Instruments

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Future electronic components to be printed like newspapers July 20th, 2018

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

Sirrus's Issued Patent Portfolio Continues To Accelerate July 18th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

Imaging

Oxford Instruments’ 22 Tesla superconducting magnet system commissioned at the UAM, making it the most intense magnetic field available outside a large international facility July 12th, 2018

Alzheimer's breakthrough: Brain metals that may drive disease progression revealed: In brains affected by Alzheimer's, researchers identify chemically reduced iron species, with mineral forms including a magnetic iron oxide June 22nd, 2018

Collaboration yields discovery of 12-sided silica cages June 20th, 2018

Powering the 21st Century with Integrated Photonics: UCSB-Led Team Selected for Demonstration of a Novel Waveguide Platform Which is Transparent Throughout the MWIR and LWIR Spectral Bands June 19th, 2018

Nanomedicine

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Announcements

Future electronic components to be printed like newspapers July 20th, 2018

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

Sirrus's Issued Patent Portfolio Continues To Accelerate July 18th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

Tools

The relationship between charge density waves and superconductivity? It's complicated July 19th, 2018

Oxford Instruments’ 22 Tesla superconducting magnet system commissioned at the UAM, making it the most intense magnetic field available outside a large international facility July 12th, 2018

Nanometrics to Announce Second Quarter Financial Results on July 31, 2018 July 12th, 2018

Nanometrics to Participate in the 10th Annual CEO Investor Summit 2018: Accredited investor and publishing research analyst event held concurrently with SEMICON West and Intersolar 2018 in San Francisco June 28th, 2018

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Future electronic components to be printed like newspapers July 20th, 2018

FEFU scientists reported on toxicity of carbon and silicon nanotubes and carbon nanofibers: Nanoparticles with a wide range of applying, including medicine, damage cells of microalgae Heterosigma akashivo badly. July 18th, 2018

In borophene, boundaries are no barrier: Rice U., Northwestern researchers make and test atom-thick boron's unique domains July 17th, 2018

Nano-kirigami: 'Paper-cut' provides model for 3D intelligent nanofabrication July 13th, 2018

Nanobiotechnology

UMBC researchers develop nanoparticles to reduce internal bleeding caused by blast trauma July 13th, 2018

Researchers identify cost-cutting option in treating nail fungus with nanotechnology: GW researcher Adam Friedman, M.D., studied the potential use of nitric oxide-releasing nanoparticles to improve onychomycosis treatment July 11th, 2018

New sensor technology enables super-sensitive live monitoring of human biomolecules July 3rd, 2018

Arrowhead Presents New Clinical Data on ARO-AAT at Alpha-1 National Education Conference July 1st, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project