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Home > Press > Made to measure viral drug delivery: Malvern’s Zetasizer Nano proves to be the perfect instrument for a student environment

Abstract:
While viruses are so often seen as the enemy, modern scientific techniques may soon be able to harness the strengths of a virus for drug delivery systems that are designed to treat diseases, rather than cause them. Using a Zetasizer Nano particle characterization system from Malvern Instruments, researchers at Indiana University's (IU) Molecular and Cellular Biochemistry Department have been studying self-assembled virus-based drug delivery systems that can be tuned to a particular size enabling the uptake of specific functional cargo.

Made to measure viral drug delivery: Malvern’s Zetasizer Nano proves to be the perfect instrument for a student environment

Malvern, UK | Posted on April 6th, 2011

Dr Stella Aniagyei, post doctoral research associate at the IU's Molecular and Cellular Biochemistry department explains: "Viruses tend to be nanosized, symmetrical and structurally consistent with a narrow size distribution. Despite this apparent biological simplicity, viruses are extremely good at delivering their own genome to living biological tissue. This makes them a prime target for biological engineers looking for an efficient transportation device that will deliver drug directly to infected cells."

"Here at IU's Nanocharacterization facility, the Malvern Zetasizer Nano is the ‘go to' instrument for characterization of assembled product," said Dr Aniagyei. "Structures closely resembling virus give a narrow size distribution. If they don't, then we know the process has gone off the biological path. We are currently looking at aggregation limits to move towards defining optimum ionic conditions for the assembly of nucleic acid binding to Gag proteins [one of the nine genes in the retrovirus RNA genome]."

Malvern's Zetasizer range uses light scattering techniques to measure hydrodynamic size, zeta potential and molecular weight of proteins and nanoparticles. According to Dr Aniagyei, "Malvern's Zetasizer Nano is very useful for protein characterization. The ease with which it can be used makes it the perfect instrument for the student environment. It definitely is one of the easiest instruments I've had to work with."

Indiana University (IU) is already in the spotlight having just received $900,000 from the Ovarian Cancer Research Fund, or OCRF, to help them prepare the new drug SGI-110 for clinical trials in patients whose once-thwarted ovarian cancer has returned. However, this work is not the only IU project at the cutting edge. Established on July 1 2009, the Department of Molecular and Cellular Biochemistry was the first science department created on the Indiana University Bloomington campus in 33 years. Linking biology, chemistry, and medical sciences, the department's main focus is on the priority areas of structural virology and virus assembly.

For more details about the Zetasizer Nano go to www.malvern.com/zetasizer

For more about the work of Indiana University's Molecular and Cellular Biochemistry department visit www.indiana.edu/~mcbdept

Malvern, Malvern Instruments and Zetasizer are registered trademarks of Malvern Instruments Ltd

####

About Malvern Instruments
Malvern Instruments is a market leader in measuring performance controlling material properties. These include particle size, particle shape, zeta potential, molecular weight, size and conformation, rheological properties and chemical distribution. Malvern delivers the systems, support and expertise that ensure the analytical integrity and productivity needed to drive research, development and manufacturing.

Malvern’s measurement solutions for scientists, technologists and engineers advance continually through customer collaboration. Complementary materials characterization systems deliver inter-related measurements that reflect the complexities of particulates and disperse systems, nanomaterials and macromolecules. Combining intelligently implemented technologies with in-depth industry applications knowledge and support, Malvern provides customers with the competitive advantage they demand.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Korea and Japan, a joint venture in India, a global distributor network and applications laboratories around the world.

For more information, please click here

Contacts:
For press information, please contact:
Trish Appleton
Kapler Communications Knowledge Centre, Wyboston Lakes, Great North Road
Wyboston, Bedfordshire, MK44 3BY, UK
Tel: +44 (0)1480 479280
Fax: +44 (0)1480 470343


USA contact:
Marisa Fraser
Malvern Instruments Inc.
117 Flanders Road
Westborough, MA 01581-1042 USA
Tel: +1 508 768 6400
Fax: +1 508 768 6403


Please send sales enquiries to:
Alison Vines
Malvern Instruments Ltd
Enigma Business Park, Grovewood Road
Malvern, Worcestershire WR14 1XZ UK
Tel: +44 (0) 1684 892456
Fax: +44 (0) 1684 892789

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