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Researchers at micromod Partikeltechnologie GmbH are using the Zetasizer Nano particle characterization system from Malvern Instruments, equipped with an MPT-2 Autotitrator and degasser, to determine particle size and to measure the zeta potential of nanoparticles as a function of pH.
micromod Partikeltechnologie GmbH develops and produces functional nano- and micro-particles for biochemical applications, with magnetic nanoparticles being the key products. The Zetasizer Nano is used in all new and enhanced product development, to create formulations with the appropriate release criteria in terms of particle size and surface potential, and for the quality control of finished products. Particle size is an important criterion for product release in accordance with the company's strict quality standards, which include ISO 9001:2008, and EN ISO 13485:2003 / AC 2007.
Dr. Cordula Grüttner from micromod Partikeltechnologie explains: "We use the Zetasizer Nano to measure the size distributions of particles from 15 nm to 2 microns in diameter. In the course of chemical or biochemical surface modification of particles, it is also important for us to follow the colloidal stability of the systems by measuring the size distribution, and to prevent aggregation of particles by selecting appropriate conditions. We test the quality of the surface modifications - which may involve introducing functional groups or coating the particles with biomolecules such as proteins and antibodies - by measuring zeta potential as a function of pH using the Autotitrator. This measurement additionally helps us in the application-specific development and optimization of surface particles in cooperation with our customers."
"We produce particles of many different materials including silicates, dextran-iron oxide composites, polystyrene and poly-lactic acid, and all have different physical properties. The ability to measure rapidly with no cleaning between measurements was a key factor in the choice of system, as was the provision of disposable cuvettes."
"We very much value the customer service and training opportunities from Malvern," concludes Cordula Grüttner, "In particular, the rapid diagnosis of any issues through direct internet connection with the Malvern customer service team has prevented us from suffering production downtime."
Zetasizer Nano particle characterization systems from Malvern Instruments measure particle size, zeta potential and molecular weight. Applications range from characterizing high concentration colloids and nanoparticles, through to measurement of dilute proteins and macromolecules in their native state, requiring as little as 12 microlitres of sample.
For more details about micromod Partikeltechnologie GmbH visit: www.micromod.de
For information on Malvern Zetasizer systems go to: www.malvern.com/zetasizer
Malvern, Malvern Instruments and Zetasizer are registered trademarks of Malvern Instruments Ltd
About Malvern Instruments
Malvern Instruments is a market leader in measuring performance controlling material properties. These include particle size, particle shape, zeta potential, molecular weight, size and conformation, rheological properties and chemical distribution. Malvern delivers the systems, support and expertise that ensure the analytical integrity and productivity needed to drive research, development and manufacturing.
Malvern’s measurement solutions for scientists, technologists and engineers advance continually through customer collaboration. Complementary materials characterization systems deliver inter-related measurements that reflect the complexities of particulates and disperse systems, nanomaterials and macromolecules. Combining intelligently implemented technologies with in-depth industry applications knowledge and support, Malvern provides customers with the competitive advantage they demand.
Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, China, Korea and Japan, a joint venture in India, a global distributor network and applications laboratories around the world.
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