Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > MSU team developing new way to fight influenza

Abby Leary and Jim Wiley work with an aerosolization chamber used to innoculate the lung. (MSU photo by Kelly Gorham).
Abby Leary and Jim Wiley work with an aerosolization chamber used to innoculate the lung. (MSU photo by Kelly Gorham).

Abstract:
Montana State University scientists are researching the use of nanomaterials to develop a new way of fighting influenza and other respiratory infections caused by viruses.

MSU team developing new way to fight influenza

Bozeman, MT | Posted on February 22nd, 2010

If it works in humans the way it does in mice, people will prepare for a respiratory viral assault by inhaling an aerosol spray containing tiny protein cages that will activate an immune response in their lungs. This activated immune state will be good against any respiratory virus and last more than a month. People won't have to wait for scientists to analyze new viruses, develop vaccines against them, then distribute and administer the vaccine.

"It's like having a fire department at your house before the fire. If a fire starts, you don't have to call them and wait for them to arrive. They are already there," said Jim Wiley, assistant research professor in the Department of Veterinary Molecular Biology in MSU's College of Agriculture.

Wiley has been working on the protein cage nanomaterial approach for more than 2 1/2 years. A recent $275,000 grant from the National Institutes of Allergy and Infectious Diseases will allow his research team to continue another two years. The grant was made possible through the American Recovery and Reinvestment Act of 2009.

The hollow protein cages he uses in his research are prepared in MSU's Center for Bio-Inspired Nanomaterials, Wiley said. These protein cages are made by a heat-loving bacterium, and they are similar to one which the Center for Bio-Inspired Nanomaterials recently isolated from a bacterium that thrives in the thermal features of Yellowstone National Park. The cages are hollow spheres that carry nothing on the outside. They are so small that they have to be magnified 50,000 times to be seen under an electron microscope. A human hair is 7,000 to 10,000 times wider than these cages.

The cages alone are enough to set off an immune response in the lungs, Wiley said. If the approach works in humans, people who have prepared their lungs with nanomaterials might sniffle for a couple of days instead of being hospitalized. Rather than missing work for a few days with an influenza infection, they may only need to sleep a few extra hours at night.

"You would be able to prepare an entire population for an imminent respiratory viral infection, like the swine influenza infections that we just experienced," Wiley said.

Wiley and 10 co-authors from MSU, Utah State University and the University of Rochester Medical Center have already published a scientific paper on the nanomaterial approach, which is based upon activating "inducible Bronchus-Associated Lymphoid Tissue," or iBALT, in the lung. This iBALT is a naturally occurring tissue that is made in the lung as part of the normal immune response to an infection. The paper showed that the presence of iBALT accelerated the recovery of infected mice without causing lung damage or other harmful side effects. The acceleration effect of the treatment disappeared gradually after one month. The paper about it ran in the September 2009 edition of PLoS One, an online scientific journal from the Public Library of Science.

MSU co-authors of the paper were Laura Richert, Steve Swain, Ann Harmsen, Mark Jutila and Allen Harmsen in the Department of Veterinary Molecular Biology; Trevor Douglas, Chris Broomell and Mark Young in the Center for Bio-Inspired Nanomaterials. Douglas and Broomell are also in the Department of Chemistry and Biochemistry. Young is also in the Department of Plant Sciences and Plant Pathology.

In the current project, Wiley said he and his team are testing this iBALT-based therapy in animal models, whose response to influenza infection is close to that seen in humans. He doesn't know when this iBALT-based approach will be tested in humans, but said, "It certainly is promising as a treatment right at the moment."

He added that nanomaterials could be generated much faster than vaccines.

Wiley's current research team consists of Richert and four lab technicians: Abby Leary, Rebecca Pulman, Soo Han and Mark McAlpine. Richert is a doctoral student from Idaho.

"I have been excited to work on it," Richert said about the project. "It has been interesting from a non-traditional immunological standpoint."

Wiley said if iBALT-based therapies had been in place last year, people would have been better prepared for H1N1.

"If we had been able to develop a state of immune preparedness in the lungs or a partial activation state in the lungs, we could have at least given people some degree of protection," Wiley said.

MSU Technology Transfer Officer Nick Zelver said MSU has a patent on using protein cages to trigger the rapid production of lymphoid tissue in the lung. The technology could be used to prevent or treat a range of pulmonary diseases including influenza. It might counter bioterrorism threats, such as airborne microbes. The protein cage technology is available for licensing from MSU.

To see all MSU technologies available for licensing, go to tto.montana.edu/technologies

####

About Montana State University
Designated as one of 96 research universities with "very high research activity" by the Carnegie Foundation for the Advancement of Teaching, MSU offers significant opportunities for research, scholarship and creative work. This highest tier classification-out of 4,400 institutions-distinguishes MSU as the only institution in the five-state region of Montana, Wyoming, Idaho and North and South Dakota to achieve this level of research prominence.

For more information, please click here

Contacts:
Evelyn Boswell
(406) 994-5135

Copyright © Montana State University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A 'movie' of ultrafast rotating molecules at a hundred billion per second: A quantum wave-like nature was successfully observed in rotating nitrogen molecules July 4th, 2015

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Possible Futures

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Harris & Harris Group Portfolio Company D-Wave Systems Announces 1,000 Qubit Processor and is Discussed in the Economist June 23rd, 2015

Global Nanoclays Market Analysis, Size, Growth, Trends And Segment Forecasts, 2015 To 2022: Grand View Research, Inc June 15th, 2015

Healthcare Nanotechnology (Nanomedicine) Market Size To 2020 June 5th, 2015

Academic/Education

Oxford Instruments’ TritonXL Cryofree dilution refrigerator selected for the Oxford NQIT Quantum Technology Hub project June 30th, 2015

Rice University boots up powerful microscopes: New electron microscopes will capture images at subnanometer resolution June 29th, 2015

Six top Catalan research centres constitute ‘The Barcelona Institute of Science and Technology’ to pursue a joint scientific endeavour June 27th, 2015

Lancaster University revolutionary quantum technology research receives funding boost June 22nd, 2015

Nanomedicine

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Iranian Scientists Find Simple, Economic Method to Synthesize Antibacterial Nanoparticles July 2nd, 2015

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Announcements

A 'movie' of ultrafast rotating molecules at a hundred billion per second: A quantum wave-like nature was successfully observed in rotating nitrogen molecules July 4th, 2015

New Biosensor Produced in Iran to Detect Effective Drugs in Cancer Treatment July 4th, 2015

Clues to inner atomic life from subtle light-emission shifts: Hyperfine structure of light absorption by short-lived cadmium atom isotopes reveals characteristics of the nucleus that matter for high precision detection methods July 3rd, 2015

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Patents/IP/Tech Transfer/Licensing

GLOBALFOUNDRIES Completes Acquisition of IBM Microelectronics Business: Transaction adds differentiating technologies, world-class technologists, and intellectual property July 1st, 2015

NEI Announces the Issuance of Multiple Patents on Self-Healing & Superhydrophobic Coatings June 30th, 2015

Solegear Further Strengthens its Product Development Team: New Hire Seeks to Create New, Disruptive, Sustainable Materials June 17th, 2015

High-tech nanofibres could help nutrients in food hit the spot June 17th, 2015

Homeland Security

Iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd, 2015

New sensing tech could help detect diseases, fraudulent art, chemical weapons June 1st, 2015

UCLA nanoscientists are first to model atomic structures of three bacterial nanomachines: Cryo electron microscope enables scientists to explore the frontiers of targeted antibiotics April 21st, 2015

Optics, nanotechnology combined to create low-cost sensor for gases April 3rd, 2015

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Pioneering Southampton scientist awarded prestigious physics medal July 3rd, 2015

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

World’s 1st Full-Color, Flexible, Skin-Like Display Developed at UCF June 24th, 2015

Physicists fine-tune control of agile exotic materials: Tunable hybrid polaritons realized with graphene layer on hexagonal boron nitride June 24th, 2015

Nanobiotechnology

Groundbreaking research to help control liquids at micro and nano scales July 3rd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Nanometric sensor designed to detect herbicides can help diagnose multiple sclerosis June 23rd, 2015

Newly-Developed Biosensor in Iran Detects Cocaine Addiction June 23rd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project