Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > MSU team developing new way to fight influenza

Abby Leary and Jim Wiley work with an aerosolization chamber used to innoculate the lung. (MSU photo by Kelly Gorham).
Abby Leary and Jim Wiley work with an aerosolization chamber used to innoculate the lung. (MSU photo by Kelly Gorham).

Abstract:
Montana State University scientists are researching the use of nanomaterials to develop a new way of fighting influenza and other respiratory infections caused by viruses.

MSU team developing new way to fight influenza

Bozeman, MT | Posted on February 22nd, 2010

If it works in humans the way it does in mice, people will prepare for a respiratory viral assault by inhaling an aerosol spray containing tiny protein cages that will activate an immune response in their lungs. This activated immune state will be good against any respiratory virus and last more than a month. People won't have to wait for scientists to analyze new viruses, develop vaccines against them, then distribute and administer the vaccine.

"It's like having a fire department at your house before the fire. If a fire starts, you don't have to call them and wait for them to arrive. They are already there," said Jim Wiley, assistant research professor in the Department of Veterinary Molecular Biology in MSU's College of Agriculture.

Wiley has been working on the protein cage nanomaterial approach for more than 2 1/2 years. A recent $275,000 grant from the National Institutes of Allergy and Infectious Diseases will allow his research team to continue another two years. The grant was made possible through the American Recovery and Reinvestment Act of 2009.

The hollow protein cages he uses in his research are prepared in MSU's Center for Bio-Inspired Nanomaterials, Wiley said. These protein cages are made by a heat-loving bacterium, and they are similar to one which the Center for Bio-Inspired Nanomaterials recently isolated from a bacterium that thrives in the thermal features of Yellowstone National Park. The cages are hollow spheres that carry nothing on the outside. They are so small that they have to be magnified 50,000 times to be seen under an electron microscope. A human hair is 7,000 to 10,000 times wider than these cages.

The cages alone are enough to set off an immune response in the lungs, Wiley said. If the approach works in humans, people who have prepared their lungs with nanomaterials might sniffle for a couple of days instead of being hospitalized. Rather than missing work for a few days with an influenza infection, they may only need to sleep a few extra hours at night.

"You would be able to prepare an entire population for an imminent respiratory viral infection, like the swine influenza infections that we just experienced," Wiley said.

Wiley and 10 co-authors from MSU, Utah State University and the University of Rochester Medical Center have already published a scientific paper on the nanomaterial approach, which is based upon activating "inducible Bronchus-Associated Lymphoid Tissue," or iBALT, in the lung. This iBALT is a naturally occurring tissue that is made in the lung as part of the normal immune response to an infection. The paper showed that the presence of iBALT accelerated the recovery of infected mice without causing lung damage or other harmful side effects. The acceleration effect of the treatment disappeared gradually after one month. The paper about it ran in the September 2009 edition of PLoS One, an online scientific journal from the Public Library of Science.

MSU co-authors of the paper were Laura Richert, Steve Swain, Ann Harmsen, Mark Jutila and Allen Harmsen in the Department of Veterinary Molecular Biology; Trevor Douglas, Chris Broomell and Mark Young in the Center for Bio-Inspired Nanomaterials. Douglas and Broomell are also in the Department of Chemistry and Biochemistry. Young is also in the Department of Plant Sciences and Plant Pathology.

In the current project, Wiley said he and his team are testing this iBALT-based therapy in animal models, whose response to influenza infection is close to that seen in humans. He doesn't know when this iBALT-based approach will be tested in humans, but said, "It certainly is promising as a treatment right at the moment."

He added that nanomaterials could be generated much faster than vaccines.

Wiley's current research team consists of Richert and four lab technicians: Abby Leary, Rebecca Pulman, Soo Han and Mark McAlpine. Richert is a doctoral student from Idaho.

"I have been excited to work on it," Richert said about the project. "It has been interesting from a non-traditional immunological standpoint."

Wiley said if iBALT-based therapies had been in place last year, people would have been better prepared for H1N1.

"If we had been able to develop a state of immune preparedness in the lungs or a partial activation state in the lungs, we could have at least given people some degree of protection," Wiley said.

MSU Technology Transfer Officer Nick Zelver said MSU has a patent on using protein cages to trigger the rapid production of lymphoid tissue in the lung. The technology could be used to prevent or treat a range of pulmonary diseases including influenza. It might counter bioterrorism threats, such as airborne microbes. The protein cage technology is available for licensing from MSU.

To see all MSU technologies available for licensing, go to tto.montana.edu/technologies

####

About Montana State University
Designated as one of 96 research universities with "very high research activity" by the Carnegie Foundation for the Advancement of Teaching, MSU offers significant opportunities for research, scholarship and creative work. This highest tier classification-out of 4,400 institutions-distinguishes MSU as the only institution in the five-state region of Montana, Wyoming, Idaho and North and South Dakota to achieve this level of research prominence.

For more information, please click here

Contacts:
Evelyn Boswell
(406) 994-5135

Copyright © Montana State University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

Possible Futures

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

New method for analyzing crystal structure: Exotic materials called photonic crystals reveal their internal characteristics with new method November 30th, 2016

Academic/Education

Oxford Nanoimaging report on how the Nanoimager, a desktop microscope delivering single molecule, super-resolution performance, is being applied at the MRC Centre for Molecular Bacteriology & Infection November 22nd, 2016

The University of Applied Sciences in Upper Austria uses Deben tensile stages as an integral part of their computed tomography research and testing facility October 18th, 2016

Enterprise In Space Partners with Sketchfab and 3D Hubs for NewSpace Education October 13th, 2016

New Agricultural Research Center Debuts at UCF October 12th, 2016

Nanomedicine

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Nanopolymer-modified protein array can pinpoint hard-to-find cancer biomarker November 17th, 2016

Nanotechnology Treatment Found to Inhibit Mesothelioma Tumor Growth November 16th, 2016

Announcements

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

Patents/IP/Tech Transfer/Licensing

Keystone Nano Announces The US FDA Has Awarded Orphan Drug Designation For Ceramides For The Treatment Of Liver Cancer November 8th, 2016

Leti to Tackle Tomorrow's Research Strategies with Stanford University’s SystemX Alliance: French R&D Center Is the First Research Institute to Join the Collaboration and Provides Bridges Between Academia and Industry, Leveraging Alliance’s Potential October 4th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

NIST Patents Single-Photon Detector for Potential Encryption and Sensing Apps September 16th, 2016

Homeland Security

Nanosensors on the alert for terrorist threats: Scientists interested in the prospects of gas sensors based on binary metal oxide nanocomposites November 5th, 2016

Nanobionic spinach plants can detect explosives: After sensing dangerous chemicals, the carbon-nanotube-enhanced plants send an alert November 2nd, 2016

Notre Dame researchers find transition point in semiconductor nanomaterials September 6th, 2016

Down to the wire: ONR researchers and new bacteria August 18th, 2016

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

'Back to the Future' inspires solar nanotech-powered clothing November 15th, 2016

2-D material a brittle surprise: Rice University researchers finds molybdenum diselenide not as strong as they thought November 14th, 2016

New Book by Nobel Laureate Tells Story of Chemistry’s New Field: Fraser Stoddart explains the mechanical bond and where it is taking scientists November 11th, 2016

Nanobiotechnology

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Making spintronic neurons sing in unison November 18th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project