Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Highly sensitive dopamine detector uses 2D materials

Schematic of a highly selective dopamine detector using two-dimensional material.

CREDIT
Derrick Butler, Penn State
Schematic of a highly selective dopamine detector using two-dimensional material. CREDIT Derrick Butler, Penn State

Abstract:
A supersensitive dopamine detector can help in the early diagnosis of several disorders that result in too much or too little dopamine, according to a group led by Penn State and including Rensselaer Polytechnic Institute and universities in China and Japan.

Highly sensitive dopamine detector uses 2D materials

University Park, PA | Posted on August 7th, 2020

Dopamine is an important neurotransmitter that can be used to diagnose disorders such as Parkinson's disease, Alzheimer's disease and schizophrenia.

"If you can develop a very sensitive, yet simple-to-use and portable, detector that can identify a wide range of dopamine concentration, for instance in sweat, that could help in non-invasive monitoring of an individual's health," said Aida Ebrahimi, assistant professor of electrical engineering, Penn State, and a corresponding author on a paper published Aug. 7 in Science Advances.

Their work shows that by adding a small amount of manganese to a two-dimensional layered material called molybdenum disulfide, they can improve the sensitivity by many orders of magnitude compared to other reported results, while also achieving high specificity. Importantly, their detector is low-cost and flexible, and can detect dopamine in background media including buffer, serum and sweat, and in real-time.

"Regarding our method, electrochemical deposition is a new way of depositing these chemicals that is very simple and scalable," said Mauricio Terrones, Verne M. Willaman Professor of Physics, Materials Science and Chemistry and the second corresponding author. "The air force is interested in these neurotransmitters that are makers of stress. I envision this as a wearable sensor."

Humberto Terrones and his group, at RPI, performed the computational investigation that allowed them to explain how addition of manganese results in an improved response to dopamine. The experimental work was performed within the Center for Atomically Thin Multifunctional Coatings (ATOMIC) at Penn State.

"Combining the experimental results with computational studies proved to be very insightful, and I think we all learned much more throughout this project because of that," said Derrick Butler, a co-lead author on the paper and doctoral student at Penn State. "Developing these materials and applying them in a way that could improve the health and well-being of others makes the work especially enjoyable and rewarding."

His co-lead author, doctoral candidate Yu Lei, added, "One challenge is to develop a scalable method to bridge fundamental studies and practical applications. Our method is based on electrodeposition, which has been widely used in industry, thus providing a scalable route to functionalize MoS2 in a scalable way. Also, I believe this multidisciplinary team is the key to find the right way to functionalize MoS2 for ultrasensitive dopamine detection."

In further work, the group hopes to find other material combinations to detect a variety of other biomarkers with the specificity of their current sensor. Creating such a "toolkit" combining experimental investigations with computational methods will lead to new materials with multifunctional capabilities. This might be useful beyond human health, for example, for detecting noxious gases, water contamination or biodefense agents.

"In future, we can envision a combined sensor/actuator that can detect the dopamine and provide therapy at the same time. The sensors can be integrated with miniaturized chips for integration of sensing, actuating, control and data processing," Ebrahimi said.

###

In addition to Ebrahimi, Lei, Butler and the Terrones brothers, authors include Fu Zhang and Tomotaroh Granzier-Nakajiwa, former or current doctoral students at Penn State, and Kazinora Fujisawa, currently a post-doctoral scholar, Penn State. Their paper is titled "Single-Atom Doping of MoS2 with Manganese Enables Ultrasensitive Detection of Dopamine: Experimental and Computational Approach."

National Science Foundation, IUCRC-ATOMIC Center and Ebrahimi's Start-up fund provided support for this project.

####

For more information, please click here

Contacts:
A'ndrea Elyse Messer

814-865-5689

@penn_state

Terrones can be contacted at
Ebrahimi can be contacted at

Copyright © Penn State

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

The National Space Society Mourns the Passing of Robert Krone, Founder of the Kepler Space Institute: Krone's Visionary and Humanistic Approach to the Study of Space Communities and Settlement Was Unique September 22nd, 2021

Researchers reveal multi-path mechanism in electrochemical CO2 reduction September 17th, 2021

Scientists demonstrate pathway to forerunner of nanotubes that could lead to widespread industrial fabrication September 17th, 2021

2 Dimensional Materials

A simple way to get complex semiconductors to assemble themselves: Much like crystallizing rock candy from sugar syrup, the new method grows 2D perovskites precisely layered with other 2D materials to produce crystals with a wide range of electronic properties September 17th, 2021

Silver nanoparticles boost performance of microbial fuel cells September 17th, 2021

Wearable electronics

A molecule like a nanobattery: Chemical scientists decipher complex electronic structure of a three-nuclear metallorganic compound with the capacity of donating and receiving multiple electrons June 9th, 2021

New brain-like computing device simulates human learning: Researchers conditioned device to learn by association, like Pavlov's dog April 30th, 2021

CEA-Leti Announces EU Project to Mimic Multi-Timescale Processing of Biological Neural Systems: Targeted Applications Include High-Dimensional Distributed Environmental Monitoring, Implantable Medical-Diagnostic Microchips, Wearable Electronics & Human/Computer Interfaces April 23rd, 2021

Threads that sense how and when you move? New technology makes it possible: Engineers created thread sensors that can be attached to skin to measure movement in real time, with potential implications for tracking health and performance January 29th, 2021

Govt.-Legislation/Regulation/Funding/Policy

A simple way to get complex semiconductors to assemble themselves: Much like crystallizing rock candy from sugar syrup, the new method grows 2D perovskites precisely layered with other 2D materials to produce crystals with a wide range of electronic properties September 17th, 2021

Scientists demonstrate pathway to forerunner of nanotubes that could lead to widespread industrial fabrication September 17th, 2021

Lehigh University to lead ‘integrative partnerships’ for multi-university research collaboration in advanced optoelectronic material development: 5-year, $25 million NSF investment in IMOD, a revolutionary center for optoelectronic, quantum technologies September 10th, 2021

Stretching the capacity of flexible energy storage September 10th, 2021

Possible Futures

The National Space Society Mourns the Passing of Robert Krone, Founder of the Kepler Space Institute: Krone's Visionary and Humanistic Approach to the Study of Space Communities and Settlement Was Unique September 22nd, 2021

Ultrasound at the nanometre scale reveals the nature of force September 17th, 2021

A simple way to get complex semiconductors to assemble themselves: Much like crystallizing rock candy from sugar syrup, the new method grows 2D perovskites precisely layered with other 2D materials to produce crystals with a wide range of electronic properties September 17th, 2021

Getting to the root of tooth replantation challenges: Researchers from Tokyo Medical and Dental University (TMDU) report a delivery system that promotes healing in tooth replantation in rats September 17th, 2021

Sensors

Engineering various sources of loss provides new features for perfect light absorption: "Loss is ubiquitous in nature, and by better understanding it, we make it more useful" September 10th, 2021

Leibniz Prize winner Professor Dr. Oliver G. Schmidt moves to Chemnitz University of Technology: President Professor Dr. Gerd Strohmeier refers to an 'absolute top transfer' September 10th, 2021

Ultrafast & ultrathin: new physics professor at TU Dresden makes mysterious quantum world visible September 10th, 2021

Engineers develop prototype of electronic nose September 3rd, 2021

Discoveries

The National Space Society Mourns the Passing of Robert Krone, Founder of the Kepler Space Institute: Krone's Visionary and Humanistic Approach to the Study of Space Communities and Settlement Was Unique September 22nd, 2021

Researchers reveal multi-path mechanism in electrochemical CO2 reduction September 17th, 2021

Scientists demonstrate pathway to forerunner of nanotubes that could lead to widespread industrial fabrication September 17th, 2021

Silver nanoparticles boost performance of microbial fuel cells September 17th, 2021

Announcements

The National Space Society Mourns the Passing of Robert Krone, Founder of the Kepler Space Institute: Krone's Visionary and Humanistic Approach to the Study of Space Communities and Settlement Was Unique September 22nd, 2021

Researchers reveal multi-path mechanism in electrochemical CO2 reduction September 17th, 2021

Scientists demonstrate pathway to forerunner of nanotubes that could lead to widespread industrial fabrication September 17th, 2021

Silver nanoparticles boost performance of microbial fuel cells September 17th, 2021

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Getting to the root of tooth replantation challenges: Researchers from Tokyo Medical and Dental University (TMDU) report a delivery system that promotes healing in tooth replantation in rats September 17th, 2021

Researchers reveal multi-path mechanism in electrochemical CO2 reduction September 17th, 2021

Scientists demonstrate pathway to forerunner of nanotubes that could lead to widespread industrial fabrication September 17th, 2021

Silver nanoparticles boost performance of microbial fuel cells September 17th, 2021

Homeland Security

Sensors developed at URI can identify threats at the molecular level: More sensitive than a dog's nose and the sensors don't get tired May 21st, 2021

UCF researchers generate attosecond light from industrial laser: The ultrafast measurement of the motion of electrons inside atoms, molecules and solids at their natural time scale is known as attosecond science and could have important implications in power generation, chemical- August 25th, 2020

RIT researchers build micro-device to detect bacteria, viruses: New process improves lab-on-chip devices to isolate drug-resistant strains of bacterial infection, viruses April 17th, 2020

Nanomaterial fabric destroys nerve agents in battlefield-relevant conditions: Metal-organic framework-based composites don’t need liquid water to work January 14th, 2020

Military

Scientists demonstrate pathway to forerunner of nanotubes that could lead to widespread industrial fabrication September 17th, 2021

Putting a new theory of many-particle quantum systems to the test: Experiments show that generalized hydrodynamics accurately simulates an out-of-equilibrium quantum system September 3rd, 2021

NIST’s quantum crystal could be a new dark matter sensor Peer-Reviewed Publication August 6th, 2021

UVA Engineering researchers join quest to demonstrate photonic systems-on-chip: Future applications include faster, more efficient data centers and next-generation millimeter-wave wireless communication July 30th, 2021

Environment

Good for groundwater – bad for crops? Plastic particles release pollutants in upper soil layers: The environmental geoscientists at the Centre for Microbiology and Environmental Systems Science (CMESS) focused on a variety of parameters that contribute to plastic pollution in far September 17th, 2021

Researchers reveal multi-path mechanism in electrochemical CO2 reduction September 17th, 2021

Enhanced ambient ammonia photosynthesis by Mo-doped Bi5O7Br nanosheets with light-switchable oxygen vacancies September 3rd, 2021

Light-harvesting nanoparticle catalysts show promise in quest for renewable carbon-based fuels June 25th, 2021

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Lehigh University to lead ‘integrative partnerships’ for multi-university research collaboration in advanced optoelectronic material development: 5-year, $25 million NSF investment in IMOD, a revolutionary center for optoelectronic, quantum technologies September 10th, 2021

Leibniz Prize winner Professor Dr. Oliver G. Schmidt moves to Chemnitz University of Technology: President Professor Dr. Gerd Strohmeier refers to an 'absolute top transfer' September 10th, 2021

New molecular device has unprecedented reconfigurability reminiscent of brain plasticity: Device can be reconfigured multiple times simply by changing applied voltage September 3rd, 2021

Rice physicists find 'magnon' origins in 2D magnet: Topological feature could prove useful for encoding information in electron spins September 3rd, 2021

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project