- About Us
- Career Center
- Nano-Social Network
- Nano Consulting
- My Account
The futuristic technology of the Six Million Dollar Man -specifically a part metal and part flesh human being - won't be exclusive to Hollywood anymore. While the main character in the Six Million Dollar Man was outfitted with metals to enhance his performance, a multidisciplinary team of scientists led by the Université de Montréal has discovered a process to produce new metal surfaces that promise to lead to superior medical implants that will improve healing and allow the human body to better accept metal prostheses.
According to new research published in Nano Letters , the scientists capitalized on recent advances in nanotechnology to change how metals can influence cell growth and development in the body. A critical aspect of the finding is that the surfaces can directly stimulate cells - thereby eliminating the need for pharmaceuticals and resulting side-effects. The study is a collaboration between the Université de Montréal, McGill University, the Institut National de la Recherche Scientifique (INRS-EMT), Plasmionique Inc and the Universidade de São Paulo.
"Using chemical modification, we have produced metals with intelligent surfaces that positively interact with cells and help control the biological healing response," says Antonio Nanci, the study's senior author and a professor at the Université de Montréal's Faculty of Dentistry. "These will be the building-blocks of new and improved metal implants that are expected to significantly affect the success of orthopedic, dental and cardiovascular prostheses."
Etching produces nanoporous surfaces
Dr. Nanci and colleagues applied chemical compounds to modify the surface of the common biomedical metals such as titanium. Exposing these metals to selected etching mixtures of acids and oxidants results in surfaces with a sponge-like pattern of nano (ultra small) pits. "We demonstrated that some cells stick better to these surfaces than they do to the traditional smooth ones," says Dr. Nanci. "This is already an improvement to the standard available biomaterial."
The researchers then tested the effects of the chemically-produced nanoporous titanium surfaces on cell growth and development. They showed that the treated surfaces increased growth of bone cells, decreased growth of unwanted cells and stimulated stem cells, relative to untreated smooth ones. In addition, expression of genes required for cell adhesion and growth were increased in contact with the nanoporous surfaces.
Different etchants have different effects
Uncontrolled growth of cells on an implant is not ideal. For example, when using cardiovascular stents, it is important to limit the growth of certain cells in order not interfere with blood flow. Also, in some cases, cells can form an undesirable capsule around dental implants causing them to fall. The scientists demonstrated that treatment with specific etchants reduced the growth of unwanted cells.
"An important element of this study is how we demonstrated the selective cellular effects of etching," says Dr. Nanci. "With subtle changes in chemical composition of etching mixtures, we can alter the nanopatterns that are created on the metal surface and control consequent cellular responses."
"Our study is groundbreaking," adds Dr. Nanci. "We use simple yet very efficient chemical treatments to alter metals commonly used in the operating room. This innovative approach may ultimately hold the key to developing intelligent materials that are not only easily accepted by the human body but that can actively respond to the surrounding biological environment."
About the study:
The article "Nanoscale Oxidative Patterning of Metallic Surfaces to Modulate Cell Activity and Fate" was published in Nano Letters and was authored by Antonio Nanci (Université de Montreal), Fiorenzo Vetrone (Université de Montreal and INRS-EMT), Fabio Variola (Université de Montreal and INRS-EMT), Paulo Tambasco de Oliveira (Universidade de São Paulo), Sylvia Francis Zalzal (Université de Montreal), Ji-Hyun Yi (Université de Montreal), Johannes Sam (Université de Montreal), Karina F. Bombonato-Prado (Universide de São Paulo), Andranik Sarkissian (Plasmionique Inc. Varennes), Dmitrii F. Perepichka (McGill University), Federico Rosei (INRS-EMT) and James D. Wuest (Université de Montreal).
Partners in research:
This study was funded by the Canadian Institutes of Health Research, the Natural Science and Engineering Research Council of Canada, the Canada Foundation for Innovation, the Fonds québécois de la recherche sur la nature et les technologies, the São Paulo State Research Foundation and the Canadian Bureau for International Education.
For more information, please click here
International press attaché
Université de Montréal
Copyright © University of MontrealIf you have a comment, please Contact us.
Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
|Related News Press|
News and information
A nano-roundabout for light December 10th, 2016
Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016
Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016
Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016
UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016
A nano-roundabout for light December 10th, 2016
Chemical trickery corrals 'hyperactive' metal-oxide cluster December 8th, 2016
STMicroelectronics’ Semiconductor Chips Contribute to Connected Toothbrush from Oral-B That Sees What You Don’t: Microcontroller and Accelerometer help brushers clean their teeth more effectively October 4th, 2016
Iran to hold intl. school on application of nanomaterials in medicine September 20th, 2016
Tooth decay -- drilling down to the nanoscale: Researchers from the University of Sydney believe they have identified some nanoscale elements that govern the behavior of our teeth September 11th, 2016