Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes

5-nm size gold nanoparticles wrap around the perimeter of a DNA nanotube in a spiral pattern. The 3-D structures have been recreated from cryoelectron tomographic imaging.
5-nm size gold nanoparticles wrap around the perimeter of a DNA nanotube in a spiral pattern. The 3-D structures have been recreated from cryoelectron tomographic imaging.

Abstract:
DNA nanotubes may soon find their way into a new generation of ultra-tiny electronic and biomedical innovations

The gold standard: Biodesign Institute researchers use nanoparticles to make 3-D DNA nanotubes

Tempe, AZ | Posted on January 1st, 2009

Arizona State University researchers Hao Yan and Yan Liu imagine and assemble intricate structures on a scale almost unfathomably small. Their medium is the double-helical DNA molecule, a versatile building material offering near limitless construction potential.

In the January 2, 2009 issue of Science, Yan and Liu, researchers at ASU's Biodesign Institute and faculty in the Department of Chemistry and Biochemistry, reveal for the first time the three-dimensional character of DNA nanotubules, rings and spirals, each a few hundred thousandths the diameter of a human hair. These DNA nanotubes and other synthetic nanostructures may soon find their way into a new generation of ultra-tiny electronic and biomedical innovations.

Yan and Liu are working in the rapidly proliferating field of structural DNA nanotechnology. By copying a page from nature's guidebook, they capitalize on the DNA molecule's remarkable properties of self-assembly. When ribbonlike strands of the molecule are brought together, they fasten to each other like strips of Velcro, according to simple rules governing the pairing of their four chemical bases, (labeled A, C, T and G). From this meager alphabet, nature has wrung a mind-bending multiplicity of forms. DNA accomplishes this through the cellular synthesis of structural proteins, coded for by specific sequences of the bases. Such proteins are fundamental constituents of living matter, forming cell walls, vessels, tissues and organs. But DNA itself can also form stable architectural structures, and may be artificially cajoled into doing so.

In his research, Yan has been much inspired by nanoscale ingenuity in the natural world: "Unicellular creatures like oceanic diatoms," he points out, "contain self-assembled protein architectures." These diverse forms of enormous delicacy and organismic practicality are frequently the result of the orchestrated self-assembly of both organic and inorganic material.

Scientists in the field of structural DNA nanotechnology, including Dr. Yan's team, have previously demonstrated that pre-fab DNA elements could be induced to self-assemble, forming useful nanostructural platforms or "tiles." Such tiles are able to snap together—with jigsaw puzzle-piece specificity—through base pairing, forming larger arrays.

Yan and Liu's work in Science responds to one of the fundamental challenges in nanotechnology and materials science, the construction of molecular-level forms in three dimensions. To do so, the team uses gold nanoparticles, which can be placed on single-stranded DNA, compelling these flexible molecular tile arrays to bend away from the nanoparticles, curling into closed loops or forming spring-like spirals or nested rings, roughly 30 to 180 nanometers in diameter.

The gold nanoparticles, which coerce DNA strands to arc back on themselves, produce a force known as "steric hindrance," whose magnitude depends on the size of particle used. Using this steric hindrance, Yan and Liu have shown for the first time that DNA nanotubules can be specifically directed to curl into closed rings with high yield.

When 5 nanometer gold particles were used, a milder steric hindrance directed the DNA tiles to curl up and join complementary neighboring segments, often forming spirals of varying diameter in addition to closed rings. A 10 nanometer gold particle however, exerted greater steric hindrance, directing a more tightly constrained curling which, produced mostly closed tubules. Yan stresses that the particle not only participates in the self-assembly process as the directed material, but also as an active agent, inducing and guiding formation of the nanotube.

With the assistance of Anchi Cheng and Jonanthan Brownell at the Scripps Research Institute, they have used an imaging technique known as electron cryotomography to provide the first glimpses of the elusive 3-D architecture of DNA nanotubules. "You quickly freeze the sample in vitreous ice," he explains, describing the process. "This will preserve the native conformation of the structure." Subsequent imaging at various tilted angles allows the reconstruction of the three-dimensional nanostructure, with the gold particles providing enough electron density for crisp visualization. (see movies)

DNA nanotubules will soon be ready to join their carbon nanotube cousins, providing flexible, resilient and manipulatable structures at the molecular level. Extending control over 3-D architectures will lay the foundation for future applications in photometry, photovoltaics, touch screen and flexible displays, as well as for far-reaching biomedical advancements.

"The ability to build three-dimensional structures through self-assembly is really exciting, " Yan says. "It's massively parallel. You can simultaneously produce millions or trillions of copies."

Yan and Liu believe that controlled tubular nanostructures bearing nanoparticles may be applied to the design of electrical channels for cell-cell communication or used in the construction of various nanoelectrical devices.

####

About Arizona State University
The Biodesign Institute at Arizona State University pursues research to create personalized medical diagnostics and treatments, outpace infectious disease, clean the environment, develop alternative energy sources, and secure a safer world. Using a team approach that fuses the biosciences with nanoscale engineering and advanced computing, the Biodesign Institute collaborates with academic, industrial and governmental organizations globally to accelerate these discoveries to market. For more information, go to: www.biodesign.asu.edu

For more information, please click here

Contacts:
Joe Caspermeyer

480-313-2010

Written by Richard Harth
Science Writer
Biodesign Institute,
Arizona State University

Copyright © Arizona State University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

VIDEO: 5-nm size gold nanoparticles wrap around the perimeter of a DNA nanotube in a spiral pattern.

VIDEO: In this DNA nanotube configuration, again using 5-nm size gold nanoparticles, the nanoparticles form stacked rings around the DNA.

VIDEO: Using 10-nm-size gold nanoparticles, the DNA nanotubes form a split branch structure, with both the spiral tube splitting into two smaller stacked rings.

Related News Press

News and information

Detecting small metallic contaminants in food via magnetization: A practical metallic-contaminant detecting system using three high-Tc RF superconducting quantum interference devices (SQUIDs) July 29th, 2015

Controlling phase changes in solids: Controlling phase changes in solids July 29th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

Videos/Movies

Caught on camera: The first glimpse of powerful nanoparticles July 17th, 2015

A most singular nano-imaging technique: Berkeley Lab's SINGLE provides images of individual nanoparticles in solution July 16th, 2015

A 'movie' of ultrafast rotating molecules at a hundred billion per second: A quantum wave-like nature was successfully observed in rotating nitrogen molecules July 4th, 2015

Freezing single atoms to absolute zero with microwaves brings quantum technology closer: Atoms frozen to absolute zero using microwaves July 2nd, 2015

Chip Technology

Nanometrics Announces Upcoming Investor Events July 28th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

Quantum networks: Back and forth are not equal distances! July 28th, 2015

Superfast fluorescence sets new speed record: Plasmonic device has speed and efficiency to serve optical computers July 27th, 2015

Nanotubes/Buckyballs/Fullerenes

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

Nano-C Receives EPA Approvals for Single Walled Carbon Nanotubes July 21st, 2015

Nanomedicine

Stretching the limits on conducting wires July 25th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

Nanopaper as an optical sensing platform July 23rd, 2015

Albany College of Pharmacy and Health Sciences to Host One Week Symposium on Nanomedicine July 23rd, 2015

Nanoelectronics

Superfast fluorescence sets new speed record: Plasmonic device has speed and efficiency to serve optical computers July 27th, 2015

Spintronics: Molecules stabilizing magnetism: Organic molecules fixing the magnetic orientation of a cobalt surface/ building block for a compact and low-cost storage technology/ publication in Nature Materials July 25th, 2015

ORNL researchers make scalable arrays of 'building blocks' for ultrathin electronics July 22nd, 2015

An easy, scalable and direct method for synthesizing graphene in silicon microelectronics: Korean researchers grow 4-inch diameter, high-quality, multi-layer graphene on desired silicon substrates, an important step for harnessing graphene in commercial silicon microelectronics July 21st, 2015

Discoveries

Detecting small metallic contaminants in food via magnetization: A practical metallic-contaminant detecting system using three high-Tc RF superconducting quantum interference devices (SQUIDs) July 29th, 2015

Controlling phase changes in solids: Controlling phase changes in solids July 29th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

Announcements

Detecting small metallic contaminants in food via magnetization: A practical metallic-contaminant detecting system using three high-Tc RF superconducting quantum interference devices (SQUIDs) July 29th, 2015

Controlling phase changes in solids: Controlling phase changes in solids July 29th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

Nanobiotechnology

New computer model could explain how simple molecules took first step toward life: Two Brookhaven researchers developed theoretical model to explain the origins of self-replicating molecules July 28th, 2015

Spintronics: Molecules stabilizing magnetism: Organic molecules fixing the magnetic orientation of a cobalt surface/ building block for a compact and low-cost storage technology/ publication in Nature Materials July 25th, 2015

Programming adult stem cells to treat muscular dystrophy and more by mimicking nature July 22nd, 2015

Biophotonics - Global Strategic Business Report 2015 July 21st, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project