Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Near Infrared Nanoparticles Shine a Bright Light on Cancer

A live mouse model showing the accumulation of near infrared fluorescent nanoparticles in breast cancer tumors for enhanced imaging.
A live mouse model showing the accumulation of near infrared fluorescent nanoparticles in breast cancer tumors for enhanced imaging.

Abstract:
A new imaging method for breast cancer has been developed by a team of scientists from Penn State utilizing encapsulated fluorescent molecules in calcium phosphate nanoparticles and non-toxic near infrared imaging.

Near Infrared Nanoparticles Shine a Bright Light on Cancer

University Park, PA | Posted on September 25th, 2008

A new imaging method for breast cancer has been developed by a team of scientists from Penn State Milton S. Hershey Medical Center and Penn State College of Medicine and the departments of Materials Science and Engineering and Physics at Penn State. Their research, utilizing encapsulated fluorescent molecules in calcium phosphate nanoparticles and non-toxic near infrared imaging (NIR), appears in the Sept. 19 on-line issue of ACS Nano.

More effective early detection of diseases is one of the promises of nanotechnology. Current imaging methods, such as x-rays and magnetic resonance imaging, are limited in the size of tumors they can detect, the depth they can penetrate the body, and by their potential side effects. Another promising imaging technique, near infrared bioimaging, is a noninvasive, painless, and non-ionizing form of radiation that operates at wavelengths just above that of visible light. By combining NIR imaging with nanoparticles containing a NIR fluorescing dye, indocyanine green, the researchers were able to detect 5mm diameter breast cancer tumors in a live mouse model over a period of four or more days.

Indocyanine green is the only NIR organic dye approved by the Food and Drug Administration (FDA) for use in the human body. The nanoparticles, which are around 20 nm in diameter—one five thousandth the diameter of a human hair—are made of calcium phosphate, a biocompatible material that has long been used as a bone replacement. Unlike other nanoparticles considered for imaging and drug delivery, e.g., semiconductor quantum dots, the biodegradable components of calcium phosphate nanoparticles are already widely present in the bloodstream.

In addition to the combination of near infrared imaging and nanoparticles, a second innovation is the development of a fundamentally new method for processing nanoparticulates. The process is called van der Waals HPLC, which stands for high performance liquid chromatography. Materials scientist Jim Adair, whose team synthesized the particles, says "Our technique takes advantage of the large van der Waals forces associated with particles, as opposed to the small van der Waals forces associated with molecules, atoms, and ions. The hard part in the synthesis was making sure the particles did not clump together. The critical stage was the laundering of all the nonessential byproducts associated with the synthesis. By the end, we had a very clean suspension of particles in which all the spectator ions, molecules, and atoms had been washed away from the basic nanoparticles."

The Hershey group, led by pharmacologist Mark Kester, showed that their nanoparticles provide the fluorescent dye with 200% greater photoefficiency compared to indocynine green injected into the bloodstream, with a 500% greater photostability. In a separate experiment discussed in the paper, the researchers were able to image through 3cm of dense pig muscle tissue, which should correlate to at least 10 cm, and likely much deeper, in patients, according to Adair.

Support for this research was provided by the Penn State Materials Research Institute and Penn State Hershey Medical Center, Penn State College of Medicine. Partial support was also provided by Keystone Nano, Inc. Contributing to the ACS Nano article were Erhan I. Altinoglu, graduate student in materials science and engineering; Timothy J. Russin, graduate student in physics; James M. Kaiser, graduate student in pharmacology at Penn State College of Medicine; Brian M. Barth, a research associate in the Kester group; Peter Eklund, Distinguished Professor of Physics and Materials Science and Engineering; Mark Kester, G. Thomas Passananti Professor of Pharmacology; and Jim Adair, professor of materials science and engineering.

####

For more information, please click here

Contacts:
Prof. Jim Adair
(814)863-6047

Copyright © Newswise

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Graphene holds up under high pressure: Used in filtration membranes, ultrathin material could help make desalination more productive April 24th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Russian scientists create new system of concrete building structures: Sientists of Peter the Great Saint-Petersburg Polytechnic University developed a new construction technology April 24th, 2017

Nanomechanics, Inc. Unveils New Product at ICMCTF Show April 25th: Nanoindentation experts will launch the new Gemini that measures the interaction of two objects that are sliding across each other – not merely making contact April 21st, 2017

Imaging

Nanoparticles open new window for biological imaging: “Quantum dots” that emit infrared light enable highly detailed images of internal body structures April 10th, 2017

The Catholic University of Rome uses the JPK NanoWizard® AFM & CellHesion® systems to understand how cells sense and respond to mechanical stimuli April 5th, 2017

Tiny sensor lays groundwork for precision X-rays detection via endoscopy:Nanoscale fiber-integrated X-ray sensor opens new doors for medical imaging and radiotherapy March 29th, 2017

“Cysteine Rose” Wins 2016 Thermo Fisher Scientific Electron Microscopy Image Contest: Thermo Fisher honors Andrea Jacassi of the Italian Institute of Technology for image of cysteine crystals using focused ion beam techniques March 27th, 2017

Nanomedicine

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Arrowhead Presents ARC-520 and ARC-521 Clinical Data at The International Liver Congress(TM) April 20th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Nanotubes that build themselves April 14th, 2017

Announcements

Graphene holds up under high pressure: Used in filtration membranes, ultrathin material could help make desalination more productive April 24th, 2017

Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types April 24th, 2017

Russian scientists create new system of concrete building structures: Sientists of Peter the Great Saint-Petersburg Polytechnic University developed a new construction technology April 24th, 2017

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project