Nanotechnology Now





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Feds fund study of drug that may prevent radiation injury

Abstract:
Defense department funds study of nanotube-based drug made at Rice

Feds fund study of drug that may prevent radiation injury

Houston, TX | Posted on January 27th, 2008

The Department of Defense has commissioned a nine-month study from Rice University chemists and scientists in the Texas Medical Center to determine whether a new drug based on carbon nanotubes can help prevent people from dying of acute radiation injury following radiation exposure. The new study was commissioned after preliminary tests found the drug was greater than 5,000 times more effective at reducing the effects of acute radiation injury than the most effective drugs currently available.

"More than half of those who suffer acute radiation injury die within 30 days, not from the initial radioactive particles themselves but from the devastation they cause in the immune system, the gastrointestinal tract and other parts of the body," said James Tour, Rice's Chao Professor of Chemistry, director of Rice's Carbon Nanotechnology Laboratory (CNL) and principal investigator on the grant. "Ideally, we'd like to develop a drug that can be administered within 12 hours of exposure and prevent deaths from what are currently fatal exposure doses of ionizing radiation."

The Defense Advanced Research Projects Agency (DARPA) has awarded Tour and co-principal investigators J. Conyers and Valerie Moore at the University of Texas Health Science Center at Houston (UT-Houston) and Luka Milas, Kathy Mason and Jeffrey Myers at the University of Texas M.D. Anderson Cancer Center a $540,000 grant for a nine-month study of an experimental drug that the investigators have named Nanovector Trojan Horses (NTH).

NTH is made at Rice's Chemistry Department and Carbon Nanotechnology Laboratory in the Richard E. Smalley Institute for Nanoscale Science and Technology. The drug is based on single-walled carbon nanotubes, hollow cylinders of pure carbon that are about as wide as a strand of DNA. To form NTH, Rice scientists coat nanotubes with two common food preservatives -- the antioxidant compounds butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) -- and derivatives of those compounds.

"The same properties that make BHA and BHT good food preservatives, namely their ability to scavenge free radicals, also make them good candidates for mitigating the biological affects that are induced through the initial ionizing radiation event," Tour said.

In preliminary tests at M.D. Anderson in July 2007, mice showed enhanced protection when exposed to lethal doses of ionizing radiation when they were given first-generation NTH drugs prior to exposure.

"Our preliminary results are remarkable, and that's why DARPA awarded us this grant with a very compressed timeline for delivery: nine months, which is almost unheard of for an academic study of this type," Tour said. "They are very interested in finding out whether this will work in a post-exposure delivery, and they don't want to waste any time."

Ionizing radiation is any form of radioactive particle or energy that converts an atom or molecule into an ion by altering the balance between the number of protons and electrons. In living organisms, ionization often results in the creation of free radicals -- highly reactive molecules that can wreak havoc by disrupting healthy physiological processes. These free radicals induce a cascade of deleterious biological events that cause further destruction to the organism in the days and weeks after initial radiation exposure event. NTH is designed to terminate the destructive biological cascade.

Tour said the researchers are also interested in finding out whether the new drugs can prevent the unwanted side effects that cancer patients suffer after undergoing radiation therapy.

####

About Rice University
Rice University is consistently ranked one of America’s best teaching and research universities. It is distinguished by its: size—2,850 undergraduates and 1,950 graduate students; selectivity—10 applicants for each place in the freshman class; resources—an undergraduate student-to-faculty ratio of 6-to-1, and the fifth largest endowment per student among American universities; residential college system, which builds communities that are both close-knit and diverse; and collaborative culture, which crosses disciplines, integrates teaching and research, and intermingles undergraduate and graduate work. Rice’s wooded campus is located in the nation’s fourth largest city and on America’s South Coast.

For more information, please click here

Contacts:
David Ruth

713-348-6327

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

Nanospiked bacteria are the brightest hard X-ray emitters July 2nd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Producing spin-entangled electrons July 2nd, 2015

Govt.-Legislation/Regulation/Funding/Policy

New technology using silver may hold key to electronics advances July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

NIST ‘How-To’ Website Documents Procedures for Nano-EHS Research and Testing July 1st, 2015

Ultra-stable JILA microscopy technique tracks tiny objects for hours July 1st, 2015

Nanotubes/Buckyballs/Fullerenes

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

NIST ‘How-To’ Website Documents Procedures for Nano-EHS Research and Testing July 1st, 2015

Cellulose from wood can be printed in 3-D June 17th, 2015

Nanomedicine

Iranian Scientists Find Simple, Economic Method to Synthesize Antibacterial Nanoparticles July 2nd, 2015

Leti Announces Launch of First European Nanomedicine Characterisation Laboratory: Project Combines Expertise of 9 Partners in 8 Countries to Foster Nanomedicine Innovation and Facilitate Regulatory Approval July 1st, 2015

Carnegie Mellon chemists characterize 3-D macroporous hydrogels: Methods will allow researchers to develop new 'smart' materials June 30th, 2015

Chitosan coated, chemotherapy packed nanoparticles may target cancer stem cells June 30th, 2015

Discoveries

The quantum middle man July 2nd, 2015

Freezing single atoms to absolute zero with microwaves brings quantum technology closer: Atoms frozen to absolute zero using microwaves July 2nd, 2015

Producing spin-entangled electrons July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Announcements

Nanospiked bacteria are the brightest hard X-ray emitters July 2nd, 2015

Engineering the world’s smallest nanocrystal July 2nd, 2015

Producing spin-entangled electrons July 2nd, 2015

NIST Group Maps Distribution of Carbon Nanotubes in Composite Materials July 2nd, 2015

Homeland Security

Iranian Scientists Design Nano Device to Detect Cyanogen Toxic Gas June 23rd, 2015

New sensing tech could help detect diseases, fraudulent art, chemical weapons June 1st, 2015

UCLA nanoscientists are first to model atomic structures of three bacterial nanomachines: Cryo electron microscope enables scientists to explore the frontiers of targeted antibiotics April 21st, 2015

Optics, nanotechnology combined to create low-cost sensor for gases April 3rd, 2015

Military

Graphene flexes its electronic muscles: Rice-led researchers calculate electrical properties of carbon cones, other shapes June 30th, 2015

The peaks and valleys of silicon: Team of USC Viterbi School of Engineering Researchers introduce new layered semiconducting materials as silicon alternative June 27th, 2015

Opening a new route to photonics Berkeley lab researchers find way to control light in densely packed nanowaveguides June 27th, 2015

World’s 1st Full-Color, Flexible, Skin-Like Display Developed at UCF June 24th, 2015

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Discovery of nanotubes offers new clues about cell-to-cell communication July 2nd, 2015

World’s 1st Full-Color, Flexible, Skin-Like Display Developed at UCF June 24th, 2015

Physicists fine-tune control of agile exotic materials: Tunable hybrid polaritons realized with graphene layer on hexagonal boron nitride June 24th, 2015

Robust new process forms 3-D shapes from flat sheets of graphene June 23rd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project