Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > News > Alzheimer's intermediate characterised by SS NMR

January 1st, 2008

Alzheimer's intermediate characterised by SS NMR

Abstract:
A team of chemists at the University of Illinois Chicago has characterized the molecular structure of a molecular intermediate in the development of Alzheimer's disease. Using NMR the team has identified a precursor to the misfolded proteins known as plaque-forming amyloid, which is involved in Alzheimer's disease. The same results may also provide clues to understanding and treating Parkinson's and Creutzfeldt-Jakob disease which also involve protein misfolding.

Effective treatment for Alzheimer's remains elusive despite the best efforts of biomedical researchers and drug discovery teams the world over. One of the problems facing drug developers is how to explain the role of amyloid plaques. Whether or not they are a cause or a symptom of the disease is not yet known for sure, although they are certainly a hallmark of this debilitating and lethal disease. Amyloid fibrils are clumps of a fibre-like protein material that is misfolded and is present at nerve cells damaged in this devastating and tragic neurodegenerative diseases.

Now, Yoshitaka Ishii and his colleagues, Sandra Chimon, Medhat Shaibat, Christopher Jones, Diana Calero, and Buzulagu Aizezi, have trapped and characterized a crucial intermediate in the formation of amyloid plaque fibres, or fibrils, showing tiny spheres averaging just twenty nanometres in diameter assembling into sheet-like structures comparable to that seen in the formation of fibrils.

Source:
University of Illinois Chicago

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Oxford Instruments commissions high field outsert magnet system for the National High Magnetic Field Laboratory 32 Tesla magnet program April 17th, 2015

QD Vision Expands Product Line with Two-Millimeter Color LCD Display Optic: Color IQ™ Optic Enables Full-Color Gamut for Ultra-Thin Displays and All-in-One Computers April 16th, 2015

The National Science Foundation names engineering researcher Andrea Alú its Alan T. Waterman awardee for 2015: Alú is a pioneer in the field of metamaterials who has developed "cloaking" technology to make objects invisible to sensors April 16th, 2015

Molecular Machines

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Tiny bio-robot is a germ suited-up with graphene quantum dots March 24th, 2015

New remote control for molecular motors: It is now theoretically possible to remotely control the direction in which magnetic molecules spin, which opens the door to designing applications based on molecular motors March 16th, 2015

Monitoring the real-time deformation of carbon nanocoils under axial loading February 18th, 2015

Discoveries

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Major advance in artificial photosynthesis poses win/win for the environment: Berkeley Lab researchers perform solar-powered green chemistry with captured CO2 April 16th, 2015

Newly-Developed Nanocatalysts Increase Performance of Fuel Cells April 16th, 2015

Lanthanide-Organic Framework Nanothermometers Prepared by Spray-Drying April 16th, 2015

Announcements

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Oxford Instruments commissions high field outsert magnet system for the National High Magnetic Field Laboratory 32 Tesla magnet program April 17th, 2015

Newly-Developed Nanocatalysts Increase Performance of Fuel Cells April 16th, 2015

Lanthanide-Organic Framework Nanothermometers Prepared by Spray-Drying April 16th, 2015

Nanobiotechnology

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Study shows novel pattern of electrical charge movement through DNA April 14th, 2015

UAB researchers develop a harmless artificial virus for gene therapy April 8th, 2015

Pavel Levkin Is Granted Heinz Maier-Leibnitz Prize April 8th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE