Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > News > Alzheimer's intermediate characterised by SS NMR

January 1st, 2008

Alzheimer's intermediate characterised by SS NMR

Abstract:
A team of chemists at the University of Illinois Chicago has characterized the molecular structure of a molecular intermediate in the development of Alzheimer's disease. Using NMR the team has identified a precursor to the misfolded proteins known as plaque-forming amyloid, which is involved in Alzheimer's disease. The same results may also provide clues to understanding and treating Parkinson's and Creutzfeldt-Jakob disease which also involve protein misfolding.

Effective treatment for Alzheimer's remains elusive despite the best efforts of biomedical researchers and drug discovery teams the world over. One of the problems facing drug developers is how to explain the role of amyloid plaques. Whether or not they are a cause or a symptom of the disease is not yet known for sure, although they are certainly a hallmark of this debilitating and lethal disease. Amyloid fibrils are clumps of a fibre-like protein material that is misfolded and is present at nerve cells damaged in this devastating and tragic neurodegenerative diseases.

Now, Yoshitaka Ishii and his colleagues, Sandra Chimon, Medhat Shaibat, Christopher Jones, Diana Calero, and Buzulagu Aizezi, have trapped and characterized a crucial intermediate in the formation of amyloid plaque fibres, or fibrils, showing tiny spheres averaging just twenty nanometres in diameter assembling into sheet-like structures comparable to that seen in the formation of fibrils.

Source:
University of Illinois Chicago

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Harris & Harris Group to Host Conference Call on Second-Quarter 2014 Financial Results on August 15, 2014 July 23rd, 2014

UCF Nanotech Spinout Developing Revolutionary Battery Technology: Power the Next Generation of Electronics with Carbon July 23rd, 2014

Deadline Announced for Registration in 7th Int'l Nanotechnology Festival in Iran July 23rd, 2014

A Crystal Wedding in the Nanocosmos July 23rd, 2014

Molecular Machines

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

University of Illinois researchers demonstrate novel, tunable nanoantennas July 14th, 2014

Ribosome Research in Atomic Detail Offers Potential Insights into Cancer, Anemia, Alzheimer’s: New movement during decoding occurs in humans, not in bacteria July 3rd, 2014

Nanoscale velcro used for molecule transport June 25th, 2014

Discoveries

UCF Nanotech Spinout Developing Revolutionary Battery Technology: Power the Next Generation of Electronics with Carbon July 23rd, 2014

A Crystal Wedding in the Nanocosmos July 23rd, 2014

Nano-sized Chip "Sniffs Out" Explosives Far Better than Trained Dogs: TAU researcher's groundbreaking sensor detects miniscule concentrations of hazardous materials in the air July 23rd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Announcements

Harris & Harris Group to Host Conference Call on Second-Quarter 2014 Financial Results on August 15, 2014 July 23rd, 2014

UCF Nanotech Spinout Developing Revolutionary Battery Technology: Power the Next Generation of Electronics with Carbon July 23rd, 2014

Deadline Announced for Registration in 7th Int'l Nanotechnology Festival in Iran July 23rd, 2014

A Crystal Wedding in the Nanocosmos July 23rd, 2014

Nanobiotechnology

Production of Non-Virus Nanocarriers with Highest Amount of Gene Delivery July 17th, 2014

Physicists Use Computer Models to Reveal Quantum Effects in Biological Oxygen Transport: The team solved a long-standing question by explaining why oxygen – and not deadly carbon monoxide – preferably binds to the proteins that transport it around the body. July 17th, 2014

Tiny DNA pyramids enter bacteria easily -- and deliver a deadly payload July 9th, 2014

Artificial cilia: Scientists from Kiel University develop nano-structured transportation system July 4th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE