Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > News > Alzheimer's intermediate characterised by SS NMR

January 1st, 2008

Alzheimer's intermediate characterised by SS NMR

Abstract:
A team of chemists at the University of Illinois Chicago has characterized the molecular structure of a molecular intermediate in the development of Alzheimer's disease. Using NMR the team has identified a precursor to the misfolded proteins known as plaque-forming amyloid, which is involved in Alzheimer's disease. The same results may also provide clues to understanding and treating Parkinson's and Creutzfeldt-Jakob disease which also involve protein misfolding.

Effective treatment for Alzheimer's remains elusive despite the best efforts of biomedical researchers and drug discovery teams the world over. One of the problems facing drug developers is how to explain the role of amyloid plaques. Whether or not they are a cause or a symptom of the disease is not yet known for sure, although they are certainly a hallmark of this debilitating and lethal disease. Amyloid fibrils are clumps of a fibre-like protein material that is misfolded and is present at nerve cells damaged in this devastating and tragic neurodegenerative diseases.

Now, Yoshitaka Ishii and his colleagues, Sandra Chimon, Medhat Shaibat, Christopher Jones, Diana Calero, and Buzulagu Aizezi, have trapped and characterized a crucial intermediate in the formation of amyloid plaque fibres, or fibrils, showing tiny spheres averaging just twenty nanometres in diameter assembling into sheet-like structures comparable to that seen in the formation of fibrils.

Source:
University of Illinois Chicago

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Blu-ray disc can be used to improve solar cell performance: Data storage pattern transferred to solar cell increases light absorption November 25th, 2014

A*STAR SIMTech wins international award for breaking new ground in actuators: SIMTech invention can be used in an array of industries, and is critical for next generation ultra-precision systems November 24th, 2014

Molecular Machines

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster: University of Leicester research team unlocks insights into creation of new nano-materials July 25th, 2014

Discoveries

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Blu-ray disc can be used to improve solar cell performance: Data storage pattern transferred to solar cell increases light absorption November 25th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Announcements

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Blu-ray disc can be used to improve solar cell performance: Data storage pattern transferred to solar cell increases light absorption November 25th, 2014

Cooling with the coldest matter in the world November 24th, 2014

Nanobiotechnology

Quantum mechanical calculations reveal the hidden states of enzyme active sites November 20th, 2014

Tokyo Institute of Technology research: Protein-engineered cages aid studies of cell functions November 19th, 2014

A novel method for identifying the body’s ‘noisiest’ networks November 19th, 2014

Implementation of DNA Chains in Designing Nanospin Pieces November 9th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE