Home > Press > The USTC realizes In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors
![]() |
experimental results CREDIT USTC |
Abstract:
Teams led by Prof. DU Jiangfeng, Prof. SHI Fazhan and Prof. KONG Fei from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) used the Nitrogen-Vacancy (NV) center inside a single nanodiamond for quantum sensing to overcome the problem of random particle rotation.
The study was published on Oct. 7th in Nature Communications.
It is an important goal to detect and analyze molecules under physiological in situ conditions in the field of life sciences. Only by observing biomolecules under this condition can we reveal conformation changes when they realize physiological functions.
Thanks to its high sensitivity, good biocompatibility, and the characteristics of magnetic resonance detection of single molecules at room temperature atmosphere, the NV center quantum sensor is rather suitable for physiological in situ detection than traditional magnetic spectrum resonance instruments.
However, the results of tracking the movement of nanodiamond in living cells show that it rotates randomly both inside the cell and on the cell membrane, making the current common magnetic resonance detection methods ineffective.
To solve this problem, the research team designed an amplitude-modulation sequence, which will generate a series of equally spaced energy levels on the NV center.
When the energy level of the NV center matches the energy level of the measured target, resonance will occur and the state of the NV center will change.
By scanning the modulation frequency, the electron paramagnetic resonance (EPR) spectroscopy of the target can be obtained, and the position of the spectral peak is no longer affected by the spatial orientation of the NV center.
In this work, the ions in the solution environment of nanodiamond were measured by EPR spectroscopy under the condition of in situ. The research team simulated the movement of nanodiamonds in the cell to detect the solution of oxygen vanadium ions.
When there is rotation of nanodiamond, it is difficult to conduct accurate quantum manipulation of NV centers, but zero-field EPR spectrum of oxo-vanadium ions can still be measured.
This result proves in principle that it is feasible to use NV center in nanodiamond to realize the detection of intracellular physiological in-situ magnetic resonance.
The oxygen vanadium ions detected in this work itself have biological functions. The ultra-fine constant of oxygen vanadium ions can be analyzed and obtained by the EPR spectrum measured by a single moving nanodiamond.
The research team has previously relaxed the detection conditions of single-molecular magnetic resonance detection from solid conditions to aqueous solution environment, and this work has further promoted it to the in situ environment.
####
For more information, please click here
Contacts:
Jane Fan
University of Science and Technology of China
Copyright © University of Science and Technology of China
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Related Links |
Related News Press |
Quantum Physics
New method cracked for high-capacity, secure quantum communication July 5th, 2024
News and information
New organic molecule shatters phosphorescence efficiency records and paves way for rare metal-free applications July 5th, 2024
Single atoms show their true color July 5th, 2024
New method cracked for high-capacity, secure quantum communication July 5th, 2024
Searching for dark matter with the coldest quantum detectors in the world July 5th, 2024
Imaging
Single atoms show their true color July 5th, 2024
Possible Futures
New method cracked for high-capacity, secure quantum communication July 5th, 2024
Searching for dark matter with the coldest quantum detectors in the world July 5th, 2024
Atomic force microscopy in 3D July 5th, 2024
Discoveries
Efficient and stable hybrid perovskite-organic light-emitting diodes with external quantum efficiency exceeding 40 per cent July 5th, 2024
A New Blue: Mysterious origin of the ribbontail ray’s electric blue spots revealed July 5th, 2024
New organic molecule shatters phosphorescence efficiency records and paves way for rare metal-free applications July 5th, 2024
Single atoms show their true color July 5th, 2024
Announcements
New organic molecule shatters phosphorescence efficiency records and paves way for rare metal-free applications July 5th, 2024
Single atoms show their true color July 5th, 2024
New method cracked for high-capacity, secure quantum communication July 5th, 2024
Searching for dark matter with the coldest quantum detectors in the world July 5th, 2024
Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters
Single atoms show their true color July 5th, 2024
New method cracked for high-capacity, secure quantum communication July 5th, 2024
Searching for dark matter with the coldest quantum detectors in the world July 5th, 2024
Atomic force microscopy in 3D July 5th, 2024
Tools
Single atoms show their true color July 5th, 2024
Atomic force microscopy in 3D July 5th, 2024
![]() |
||
![]() |
||
The latest news from around the world, FREE | ||
![]() |
![]() |
||
Premium Products | ||
![]() |
||
Only the news you want to read!
Learn More |
||
![]() |
||
Full-service, expert consulting
Learn More |
||
![]() |