Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Fetal risk of nanoparticle exposure assessed

Abstract:
A recent collaborative venture between Chinese scientists from National Center for Nanoscience and Technology, China, and Australian scientists from University of Western Australia and Queensland Institute of Medical Research have uncovered the major factors that govern the materno-fetal transfer of nanoparticles.

Fetal risk of nanoparticle exposure assessed

Germany | Posted on November 29th, 2012

With the accelerating development and use of nanomaterials in cosmetic, medical and pharmaceutical applications, the importance of assessing the potential risks of nanomaterials to human health is growing. As the risk of exposure to nanomaterials in pregnancy increases, so does the opportunity for exposure to the developing fetus - one of the most vulnerable subgroups of society. Accordingly, the materno-fetal transfer of nano-scale substances has become of great interest in assessing the safety of nanomaterials in pregnancy for medical purposesand the associated risk of growth and developmental defects in the fetus. However, there is considerable uncertainty regarding the mechanism, extent and consequence of materno-fetal transfer of nanoparticles.

The research team designed and synthesized a series of 13 nm gold nanoparticles with different surface modifications, either citrate, polymer (PEG) or protein (ferritin protein cage). They then assessed the effect of gestational age and nanoparticle composition on fetal accumulation of maternally-administered nanomaterials in mice. Interestingly, their results showed that a critical time window exists: in early pregnancy, prior to day 11.5 of pregnancy (about half way to term), all three types of nanoparticles could be visualized and detected in fetal tissues in significant amounts; however, after this point fetal gold levels declined dramatically, although placental accumulation continued to increase. Fetal and placental accumulation of ferritin- and PEG-modified nanoparticles was 10-fold greater than citrate-capped nanoparticles. Importantly, despite the significant accumulation of Au nanoparticles in the placenta and developing fetus, no signs of toxicity were observed.

The present study has addressed important issues relating to some of the factors governing placental uptake, passage and fetal exposure. The results suggest one can modify the nanoparticle surface as required to either increase the placental targeting of therapeutic nanoparticles or decrease/avoid unnecessary fetal nanoparticle exposure during development. These novel findings in murine pregnancy have significant biomedical and biosafety implications for nanoparticle administration in pregnancy in humans and may pave the way for developing effective and safe biomedical applications of nanoparticles in pregnancy. Nevertheless, further work is urgently required to assess the importance of species differences and define the mechanisms underlying the variable permeability of nanoparticles across the placental barrier.

####

For more information, please click here

Copyright © Wiley-VCH Materials Science Journals

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Link to the original paper:

Related News Press

News and information

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Gene therapy relieves back pain, repairs damaged disc in mice: Study suggests nanocarriers loaded with DNA could replace opioids May 17th, 2024

Shedding light on perovskite hydrides using a new deposition technique: Researchers develop a methodology to grow single-crystal perovskite hydrides, enabling accurate hydride conductivity measurements May 17th, 2024

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in cuprate superconductor May 17th, 2024

Discoveries

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Finding quantum order in chaos May 17th, 2024

Advances in priming B cell immunity against HIV pave the way to future HIV vaccines, shows quartet of new studies May 17th, 2024

Announcements

Virginia Tech physicists propose path to faster, more flexible robots: Virginia Tech physicists revealed a microscopic phenomenon that could greatly improve the performance of soft devices, such as agile flexible robots or microscopic capsules for drug delivery May 17th, 2024

Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024

Finding quantum order in chaos May 17th, 2024

Oscillating paramagnetic Meissner effect and Berezinskii-Kosterlitz-Thouless transition in cuprate superconductor May 17th, 2024

Safety-Nanoparticles/Risk management

First human trial shows ‘wonder’ material can be developed safely: A revolutionary nanomaterial with huge potential to tackle multiple global challenges could be developed further without acute risk to human health, research suggests February 16th, 2024

New research may make future design of nanotechnology safer with fewer side effects: Study shows a promising strategy to reduce adverse reactions to nanoparticles by using complement inhibitors October 6th, 2023

Tests find no free-standing nanotubes released from tire tread wear September 8th, 2023

Billions of nanoplastics released when microwaving baby food containers: Exposure to plastic particles kills up to 75% of cultured kidney cells July 21st, 2023

Research partnerships

Gene therapy relieves back pain, repairs damaged disc in mice: Study suggests nanocarriers loaded with DNA could replace opioids May 17th, 2024

Discovery points path to flash-like memory for storing qubits: Rice find could hasten development of nonvolatile quantum memory April 5th, 2024

Researchers’ approach may protect quantum computers from attacks March 8th, 2024

How surface roughness influences the adhesion of soft materials: Research team discovers universal mechanism that leads to adhesion hysteresis in soft materials March 8th, 2024

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project