Home > Press > Iron Nanoparticles Spot Tumor Spread in Patients With Kidney Cancer
![]() |
Abstract:
Iron nanoparticles designed to collect in lymph nodes containing metastatic cancer cells have proven that they can help physicians detect metastatic spread of prostate cancer. Now, a team of investigators at Harvard Medical School has pilot phase data showing that these nanoparticles can detect lymph node metastases in a highly sensitive and specific manner in patients with renal cell carcinoma, which accounts for some 20% of kidney cancers.
Reporting its work in the journal Oncology, a team of researchers headed by Alexander Guimaraes, M.D., Ph.D., Mukesh Harisinghani, M.D., and Ralph Weissleder, M.D., who is the principal investigator of the MIT-Harvard Center for Cancer Nanotechnology Excellence, showed that dextran-coated iron oxide administered to nine patients with kidney tumors could clearly identify lymph node metastases and distinguish them from benign lesions using magnetic resonance (MR) imaging. These results were confirmed by traditional histopathology techniques, revealing one false-positive among the MR imaging results. MR imaging of lymph nodes did not miss detecting any metastases later identified by histopathology. The researchers conclude that these studies warrant a larger, prospective clinical trial to prove that iron oxide nanoparticles can serve as a noninvasive diagnostic for metastatic disease.
####
About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.
Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.
For more information, please click here
Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580
Copyright © National Cancer Institute
If you have a comment, please Contact us.Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
Related Links |
Related News Press |
News and information
New organic molecule shatters phosphorescence efficiency records and paves way for rare metal-free applications July 5th, 2024
Single atoms show their true color July 5th, 2024
New method cracked for high-capacity, secure quantum communication July 5th, 2024
Searching for dark matter with the coldest quantum detectors in the world July 5th, 2024
Nanomedicine
The mechanism of a novel circular RNA circZFR that promotes colorectal cancer progression July 5th, 2024
Diamond glitter: A play of colors with artificial DNA crystals May 17th, 2024
Advances in priming B cell immunity against HIV pave the way to future HIV vaccines, shows quartet of new studies May 17th, 2024
Discoveries
Efficient and stable hybrid perovskite-organic light-emitting diodes with external quantum efficiency exceeding 40 per cent July 5th, 2024
A New Blue: Mysterious origin of the ribbontail ray’s electric blue spots revealed July 5th, 2024
New organic molecule shatters phosphorescence efficiency records and paves way for rare metal-free applications July 5th, 2024
Single atoms show their true color July 5th, 2024
Announcements
New organic molecule shatters phosphorescence efficiency records and paves way for rare metal-free applications July 5th, 2024
Single atoms show their true color July 5th, 2024
New method cracked for high-capacity, secure quantum communication July 5th, 2024
Searching for dark matter with the coldest quantum detectors in the world July 5th, 2024
![]() |
||
![]() |
||
The latest news from around the world, FREE | ||
![]() |
![]() |
||
Premium Products | ||
![]() |
||
Only the news you want to read!
Learn More |
||
![]() |
||
Full-service, expert consulting
Learn More |
||
![]() |