Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Platinum nanoparticles for selective treatment of liver cancer cells

Non-oxidised platinum nanoparticles have virtually no toxic effect on normal cells (bottom left). Once inside liver cancer cells (top right), the platinum is oxidised, releasing its toxic effect.

CREDIT
ETH Zurich / Helma Wennemers
Non-oxidised platinum nanoparticles have virtually no toxic effect on normal cells (bottom left). Once inside liver cancer cells (top right), the platinum is oxidised, releasing its toxic effect. CREDIT ETH Zurich / Helma Wennemers

Abstract:
In recent years, the number of targeted cancer drugs has continued to rise. However, conventional chemotherapeutic agents still play an important role in cancer treatment. These include platinum-based cytotoxic agents that attack and kill cancer cells. But these agents also damage healthy tissue and cause severe side effects. Researchers at ETH Zurich have now identified an approach that allows for a more selective cancer treatment with drugs of this kind.

Platinum nanoparticles for selective treatment of liver cancer cells

Zurich, Switzerland | Posted on February 21st, 2019

Platinum can be cytotoxic when oxidised to platinum(II) and occurs in this form in conventional platinum-based chemotherapeutics. Non-oxidised platinum(0), however, is far less toxic to cells. Based on this knowledge, a team led by Helma Wennemers, Professor at the Laboratory of Organic Chemistry, and Michal Shoshan, a postdoc in her group, looked for a way to introduce platinum(0) into the target cells, and only then for it to be oxidised to platinum(II). To this end, they used non-oxidised platinum nanoparticles, which first had to be stabilized with a peptide. They screened a library containing thousands of peptides to identify a peptide suitable for producing platinum nanoparticles (2.5 nanometres in diameter) that are stable for years.

Oxidised inside the cell

Tests with cancer cell cultures revealed that the platinum(0) nanoparticles penetrate into cells. Once inside the specific environment of liver cancer cells, they become oxidised, triggering the cytotoxic effect of platinum(II).

Studies with ten different types of human cells also showed that the toxicity of the peptide-coated nanoparticles was highly selective to liver cancer cells. They have the same toxic effect as Sorafenib, the most common drug used to treat primary liver tumours today. However, the nanoparticles are more selective than Sorafenib and significantly more so than the well-known chemotherapeutic Cisplatin. It is therefore conceivable that the nanoparticles will have fewer side effects than conventional medication.

Joining forces with ETH Professor Detlef GŁnther and his research group, Wennemers and her team were able to determine the platinum content inside the cells and their nuclei using special mass spectrometry. They concluded that the platinum content in the nuclei of liver cancer cells was significantly higher than, for instance, in colorectal cancer cells. The authors believe that the platinum(II) ions - produced by oxidation of the platinum nanoparticles in the liver cancer cells - enter the nucleus, and there release their toxicity.

"We are still a very long and uncertain way away from a new drug, but the research introduced a new approach to improve the selectivity of drugs for certain types of cancer - by using a selective activation process specific to a given cell type," Wennemers says. Future research will expand the chemical properties of the nanoparticles to allow for greater control over their biological effects.

####

For more information, please click here

Contacts:
Helma Wennemers

41-446-333-777

Copyright © ETH Zurich

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Reference

Related News Press

News and information

Machine learning speeds modeling of experiments aimed at capturing fusion energy on Earth May 17th, 2019

Manipulating atoms one at a time with an electron beam: New method could be useful for building quantum sensors and computers May 17th, 2019

New surface treatment could improve refrigeration efficiency: A slippery surface for liquids with very low surface tension promotes droplet formation, facilitating heat transfer May 17th, 2019

Generating high-quality single photons for quantum computing: New dual-cavity design emits more single photons that can carry quantum information at room temperature May 17th, 2019

Cancer

New efficient way to engineer nanostructures mimicking natural immune response complexes: Novel method to engineer large multi-antibody-like nanostructures using DNA nanotechnology; the results demonstrate the potential for assembly of multiple proteins and also other materials t May 10th, 2019

A cautionary tale for researchers working on selective drug delivery May 9th, 2019

Vaccine design can dramatically improve cancer immunotherapies: Effectiveness depends on molecular architecture and 3D presentation of components May 6th, 2019

Scientists explore the unknown behaviour of gold nanoparticles with neutrons April 23rd, 2019

Possible Futures

Machine learning speeds modeling of experiments aimed at capturing fusion energy on Earth May 17th, 2019

Manipulating atoms one at a time with an electron beam: New method could be useful for building quantum sensors and computers May 17th, 2019

New surface treatment could improve refrigeration efficiency: A slippery surface for liquids with very low surface tension promotes droplet formation, facilitating heat transfer May 17th, 2019

Generating high-quality single photons for quantum computing: New dual-cavity design emits more single photons that can carry quantum information at room temperature May 17th, 2019

Nanomedicine

Better microring sensors for optical applications May 10th, 2019

New efficient way to engineer nanostructures mimicking natural immune response complexes: Novel method to engineer large multi-antibody-like nanostructures using DNA nanotechnology; the results demonstrate the potential for assembly of multiple proteins and also other materials t May 10th, 2019

Nanotubes enable travel of Huntington's protein: Rhes protein makes its own road to convey disease drivers May 10th, 2019

A cautionary tale for researchers working on selective drug delivery May 9th, 2019

Discoveries

Manipulating atoms one at a time with an electron beam: New method could be useful for building quantum sensors and computers May 17th, 2019

New surface treatment could improve refrigeration efficiency: A slippery surface for liquids with very low surface tension promotes droplet formation, facilitating heat transfer May 17th, 2019

Generating high-quality single photons for quantum computing: New dual-cavity design emits more single photons that can carry quantum information at room temperature May 17th, 2019

CEA-Leti Develops CMOS Process for High-Performance MicroLEDs That Could Overcome Display-Size Obstacles: New Concept Creates All-in-One RGB MicroLEDs, Eliminates Several Transfer Steps to Receiving Substrate & Boosts Performance May 16th, 2019

Announcements

Machine learning speeds modeling of experiments aimed at capturing fusion energy on Earth May 17th, 2019

Manipulating atoms one at a time with an electron beam: New method could be useful for building quantum sensors and computers May 17th, 2019

New surface treatment could improve refrigeration efficiency: A slippery surface for liquids with very low surface tension promotes droplet formation, facilitating heat transfer May 17th, 2019

Generating high-quality single photons for quantum computing: New dual-cavity design emits more single photons that can carry quantum information at room temperature May 17th, 2019

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Machine learning speeds modeling of experiments aimed at capturing fusion energy on Earth May 17th, 2019

Manipulating atoms one at a time with an electron beam: New method could be useful for building quantum sensors and computers May 17th, 2019

Generating high-quality single photons for quantum computing: New dual-cavity design emits more single photons that can carry quantum information at room temperature May 17th, 2019

New way to beat the heat in electronics: Rice University lab's flexible insulator offers high strength and superior thermal conduction May 16th, 2019

Nanobiotechnology

New efficient way to engineer nanostructures mimicking natural immune response complexes: Novel method to engineer large multi-antibody-like nanostructures using DNA nanotechnology; the results demonstrate the potential for assembly of multiple proteins and also other materials t May 10th, 2019

Nanotubes enable travel of Huntington's protein: Rhes protein makes its own road to convey disease drivers May 10th, 2019

A cautionary tale for researchers working on selective drug delivery May 9th, 2019

Vaccine design can dramatically improve cancer immunotherapies: Effectiveness depends on molecular architecture and 3D presentation of components May 6th, 2019

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project