Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Using injectable self-assembled nanomaterials for sustained delivery of drugs: New injectable delivery system can slowly release drug carriers for months

Evan Scott's hydrogel network functions as a drug depot that slowly degrades by breaking down into micelles.
Evan Scott's hydrogel network functions as a drug depot that slowly degrades by breaking down into micelles.

Abstract:
Because they can be programmed to travel the body and selectively target cancer and other sites of disease, nanometer-scale vehicles called nanocarriers can deliver higher concentrations of drugs to bombard specific areas of the body while minimizing systemic side effects. Nanocarriers can also deliver drugs and diagnostic agents that are typically not soluble in water or blood as well as significantly decrease the effective dosage.

Using injectable self-assembled nanomaterials for sustained delivery of drugs: New injectable delivery system can slowly release drug carriers for months

Evanston, IL | Posted on February 12th, 2018

Although this method might seem ideal for treating diseases, nanocarriers are not without their challenges.

"Controlled, sustained delivery is advantageous for treating many chronic disorders, but this is difficult to achieve with nanomaterials without inducing undesirable local inflammation," said Northwestern University's Evan Scott. "Instead, nanomaterials are typically administered as multiple separate injections or as a transfusion that can take longer than an hour. It would be great if physicians could give one injection, which continuously released nanomaterials over a controlled period of time."

Now Scott, an assistant professor of biomedical engineering in Northwestern's McCormick School of Engineering, has developed a new mechanism that makes that controlled, sustained delivery possible.

Scott's team designed a nanocarrier formulation that -- after quickly forming into a gel inside the body at the site of injection -- can continuously release nanoscale drug-loaded vehicles for months. The gel itself re-assembles into the nanocarriers, so after all of the drug has been delivered, no residual material is left to induce inflammation or fibrous tissue formation. This system could, for example, enable single-administration vaccines that do not require boosters as well as a new way to deliver chemotherapy, hormone therapy, or drugs that facilitate wound healing.

Supported by the National Science Foundation and National Institutes of Health, the research was published online today, February 12 in the journal Nature Communications. Nicholas Karabin, a graduate student in Scott's laboratory, was the paper's first author. Northwestern Engineering's Kenneth Shull, professor of materials science and engineering, also contributed to the work. A member of Northwestern's Simpson Querrey Institute for BioNanotechnology and Chemistry of Life Processes Institute, Scott was corresponding author and led the nanoparticle development and in vivo validation.

Currently, the most common sustained nanocarrier delivery systems hold nanomaterials within polymer matrices. These networks are implanted into the body, where they slowly release the trapped drug carriers over a period of time. The problem lies after the delivery is complete: the networks remain inside the body, often eliciting a foreign-body response. The leftover network can cause discomfort and chronic inflammation in the patient.

To bypass this issue, Scott developed a nanocarrier using self-assembled, filament-shaped nanomaterials, which are loaded with a drug or imaging agent. When crosslinked together, the filaments form a hydrogel network that is similar to structural tissue in the human body. After the filaments are injected into the body, the resulting hydrogel network functions as a drug depot that slowly degrades by breaking down into spherical nanomaterials called micelles, which are programmed to travel to specific targets. Because the network morphs into the drug-delivery system, nothing is less behind to cause inflammation.

"All of the material holds the drug and then delivers the drug," Scott explained. "It degrades in a controlled fashion, resulting in nanomaterials that are of equal shape and size. If we load a drug into the filaments, the micelles take the drug and leave with it."

After testing the system both in vitro and in vivo in an animal model, Scott's team demonstrated they could administer a subcutaneous injection that slowly delivered nanomaterials to cells in lymph nodes for over a month in a controlled fashion.

Scott said the system can be used for other nanostructures in addition to micelles. For example, the system could include vesicle-shaped nanoparticles, such as liposomes or polyersomes, that have drugs, proteins, or antibodies trapped inside. Different vesicles could carry different drugs and release them at different rates once inside the body.

"Next we are looking for ways to tailor the system to the needs of specific diseases and therapies," Scott said. "We're currently working to find ways to deliver chemotherapeutics and vaccines. Chemotherapy usually requires the delivery of multiple toxic drugs at high concentrations, and we could deliver all of these drugs in one injection at much lower dosages. For immunization, these injectable hydrogels could be administered like standard vaccines, but stimulate specific cells of the immune system for longer, controlled periods of time and potentially avoid the need for boosters."

####

For more information, please click here

Contacts:
Megan Fellman

847-491-3115

Copyright © Northwestern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

RELATED JOURNAL ARTICLE:

Related News Press

News and information

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Leti & EFI Aim to Dramatically Improve Reliability & Speed of Low-Cost Electronic Devices for Autos: Project Will Extend Model Predictive Control Technique to Microcontrollers, Digital Signal Processors and Other Devices that Lack Powerful Computation Capabilities September 18th, 2018

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

Cancer

Rice U. lab probes molecular limit of plasmonics: Optical effect detailed in organic molecules with fewer than 50 atoms September 5th, 2018

Polymer antibodies efficiently target and eliminate cancer cells August 27th, 2018

New technology can detect hundreds of proteins in a single sample: Improvement of barcoding technique offers cost-effective alternative to current technology August 13th, 2018

Camouflaged nanoparticles used to deliver killer protein to cancer June 17th, 2018

Hydrogels

DNA triggers shape-shifting in hydrogels, opening a new way to make 'soft robots' September 21st, 2017

Transparent gel-based robots can catch and release live fish: Made from hydrogel, robots may one day assist in surgical operations, evade underwater detection February 2nd, 2017

Researchers reduce expensive noble metals for fuel cell reactions August 22nd, 2016

New remote-controlled microrobots for medical operations July 23rd, 2016

Govt.-Legislation/Regulation/Funding/Policy

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Could a demon help to create a quantum computer? Physicists implement a version of Maxwell's famous thought experiment for reducing entropy September 5th, 2018

Ultracold atoms used to verify 1963 prediction about 1D electrons: Rice University, University of Geneva study focuses on theory that's increasingly relevant to chipmakers September 5th, 2018

Possible Futures

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Leti & EFI Aim to Dramatically Improve Reliability & Speed of Low-Cost Electronic Devices for Autos: Project Will Extend Model Predictive Control Technique to Microcontrollers, Digital Signal Processors and Other Devices that Lack Powerful Computation Capabilities September 18th, 2018

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

Nanomedicine

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

A Comprehensive Guide: The Future of Nanotechnology September 13th, 2018

Carbon nanodots do an ultrafine job with in vitro lung tissue: New experiments highlight the role of charge and size when it comes to carbon nanodots that mimic the effect of nanoscale pollution particles on the human lung. September 12th, 2018

Rice U. lab probes molecular limit of plasmonics: Optical effect detailed in organic molecules with fewer than 50 atoms September 5th, 2018

Announcements

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Leti & EFI Aim to Dramatically Improve Reliability & Speed of Low-Cost Electronic Devices for Autos: Project Will Extend Model Predictive Control Technique to Microcontrollers, Digital Signal Processors and Other Devices that Lack Powerful Computation Capabilities September 18th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

New photonic chip promises more robust quantum computers September 14th, 2018

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Researchers managed to prevent the disappearing of quantum information September 14th, 2018

Tiny camera lens may help link quantum computers to network September 14th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

How a tetrahedral substance can be more symmetrical than a spherical atom: A new type of symmetry September 14th, 2018

Nanobiotechnology

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

Neutrophil nanosponges soak up proteins that promote rheumatoid arthritis September 3rd, 2018

Arrowhead Pharmaceuticals to Present at Upcoming September 2018 Conferences August 31st, 2018

A human enzyme can biodegrade graphene August 28th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project