Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoshells could deliver more chemo with fewer side effects: In vitro study verifies method for remotely triggering release of cancer drugs

Researchers from Rice University and Northwestern University loaded light-activated nanoshells (gold and light blue) with the anticancer drug lapatinib (yellow) by encasing the drug in an envelope of albumin (blue). Light from a near-infrared laser (center) was used to remotely trigger the release of the drug (right) after the nanoshells were taken up by cancer cells. (Image courtesy of A. Goodman/Rice University)
Researchers from Rice University and Northwestern University loaded light-activated nanoshells (gold and light blue) with the anticancer drug lapatinib (yellow) by encasing the drug in an envelope of albumin (blue). Light from a near-infrared laser (center) was used to remotely trigger the release of the drug (right) after the nanoshells were taken up by cancer cells. (Image courtesy of A. Goodman/Rice University)

Abstract:
Researchers investigating ways to deliver high doses of cancer-killing drugs inside tumors have shown they can use a laser and light-activated gold nanoparticles to remotely trigger the release of approved cancer drugs inside cancer cells in laboratory cultures.

Nanoshells could deliver more chemo with fewer side effects: In vitro study verifies method for remotely triggering release of cancer drugs

Houston, TX | Posted on November 8th, 2017

The study by researchers at Rice University and Northwestern University Feinberg School of Medicine appears in this week's online Early Edition of the Proceedings of the National Academy of Sciences. It employed gold nanoshells to deliver toxic doses of two drugs -- lapatinib and docetaxel -- inside breast cancer cells. The researchers showed they could use a laser to remotely trigger the particles to release the drugs after they entered the cells.

Though the tests were conducted with cell cultures in a lab, the research was designed to demonstrate clinical applicability: The nanoparticles are nontoxic, the drugs are widely used and the low-power, infrared laser can noninvasively shine through tissue and reach tumors several inches below the skin.

"In future studies, we plan to use a Trojan-horse strategy to get the drug-laden nanoshells inside tumors," said Naomi Halas, an engineer, chemist and physicist at Rice University who invented gold nanoshells and has spent more than 15 years researching their anticancer potential. "Macrophages, a type of white blood cell that's been shown to penetrate tumors, will carry the drug-particle complexes into tumors, and once there we use a laser to release the drugs."

Co-author Susan Clare, a research associate professor of surgery at the Northwestern University Feinberg School of Medicine, said the PNAS study was designed to demonstrate the feasibility of the Trojan-horse approach. In addition to demonstrating that drugs could be released inside cancer cells, the study also showed that in macrophages, the drugs did not detach prior to triggering.

"Getting chemotherapeutic drugs to penetrate tumors is very challenging," said Clare, also a Northwestern Medicine breast cancer surgeon. "Drugs tend to get pushed out of tumors rather than drawn in. To get an effective dose at the tumor, patients often have to take so much of the drug that nausea and other side effects become severe. Our hope is that the combination of macrophages and triggered drug-release will boost the effective dose of drugs within tumors so that patients can take less rather than more."

If the approach works, Clare said, it could result in fewer side effects and potentially be used to treat many kinds of cancer. For example, one of the drugs in the study, lapatinib, is part of a broad class of chemotherapies called tyrosine kinase inhibitors that target specific proteins linked to different types of cancer. Other Federal Drug Administration-approved drugs in the class include imatinib (leukemia), gefitinib (breast, lung), erlotinib (lung, pancreatic), sunitinib (stomach, kidney) and sorafenib (liver, thyroid and kidney).

"All the tyrosine kinase inhibitors are notoriously insoluble in water," said Amanda Goodman, a Rice alumna and lead author of the PNAS study. "As a drug class, they have poor bioavailability, which means that a relatively small proportion of the drug in each pill is actually killing cancer cells. If our method works for lapatinib and breast cancer, it may also work for the other drugs in the class."

Halas invented nanoshells at Rice in the 1990s. About 20 times smaller than a red blood cell, they are made of a sphere of glass covered by a thin layer of gold. Nanoshells can be tuned to capture energy from specific wavelengths of light, including near-infrared (near-IR), a nonvisible wavelength that passes through most tissues in the body. Nanospectra Biosciences, a licensee of this technology, has performed several clinical trials over the past decade using nanoshells as photothermal agents that destroy tumors with infrared light.

Clare and Halas' collaboration on nanoshell-based drug delivery began more than 10 years ago. In earlier work, they showed that a near-IR continuous-wave laser -- the same kind that produces heat in the photothermal applications of nanoshells -- could be used to trigger the release of drugs from nanoshells.

In the latest study, Goodman contrasted the use of continuous-wave laser triggering and triggering with a low-power pulse laser. Using each type of laser, she demonstrated the remotely triggered release of drugs from two types of nanoshell-drug conjugates. One type used a DNA linker and the drug docetaxel, and the other employed a coating of the blood protein albumin to trap and hold lapatinib. In each case, Goodman found she could trigger the release of the drug after the nanoshells were taken up inside cancer cells. She also found no measureable premature release of drugs in macrophages in either case.

Halas and Clare said they hope to begin animal tests of the technology soon and have an established mouse model that could be used for the testing.

"I'm particularly excited about the potential for lapatinib," Clare said. "The first time I heard about Naomi's work, I wondered if it might be the answer to delivering drugs into the anoxic (depleted of oxygen) interior of tumors where some of the most aggressive cancer cells lurk. As clinicians, we're always looking for ways to keep cancer from coming back months or years later, and I am hopeful this can do that."

Additional co-authors include Oara Neumann and Luke Henderson, both of Rice, Mi-Ran Choi of Northwestern and Kamilla Nørregaard of the University of Copenhagen. The research was supported by the Department of Defense Breast Cancer Research Program, the Welch Foundation and the National Science Foundation.

####

About Rice University
Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,879 undergraduates and 2,861 graduate students, Rice’s undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for quality of life and for lots of race/class interaction and No. 2 for happiest students by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go to http://tinyurl.com/RiceUniversityoverview .

Follow Rice News and Media Relations on Twitter @RiceUNews

For more information, please click here

Contacts:
David Ruth
713-348-6327


Jade Boyd
713-348-6778

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

A copy of the paper is available at:

Related News Press

News and information

Arrowhead Pharmaceuticals Presents Late-Breaking Clinical Data on ARO-AAT at Liver Meeting® 2018 November 9th, 2018

Arrowhead Pharmaceuticals Presents Late-Breaking Preliminary Clinical Data on ARO-HBV at Liver Meeting® 2018 November 9th, 2018

Unlocking the Secrets of Metal-Insulator Transitions: X-ray photon correlation spectroscopy at NSLS-II's CSX beamline used to understand electrical conductivity transitions in magnetite November 8th, 2018

IEDM - CEA-Leti Will Present 11 Papers and Host Workshop on Disruptive Technologies for Data Management November 7th, 2018

Mode-Changing MEMS Accelerometer from STMicroelectronics Combines High Measurement Resolution and Ultra-Low Power for Industrial Applications November 7th, 2018

Cancer

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

New platform based on biology and nanotechnology carries mRNA directly to target cells: Combined platform provides safe, effective passage for therapies treating cancer and other diseases, Tel Aviv University researchers say October 29th, 2018

Govt.-Legislation/Regulation/Funding/Policy

Unlocking the Secrets of Metal-Insulator Transitions: X-ray photon correlation spectroscopy at NSLS-II's CSX beamline used to understand electrical conductivity transitions in magnetite November 8th, 2018

Physicists name and codify new field in nanotechnology: ‘electron quantum metamaterials:’ UC Riverside’s Nathaniel Gabor and colleague formulate a vision for the field in a perspective article November 5th, 2018

Nanotech Artisans Sculpt with DNA November 5th, 2018

Cerion Advanced Materials Invited by the National Nanotechnology Initiative to Discuss their Expertise in Commercialization: Webinar transcription with key takeaways available on the National Nanotechnology Initiative website November 2nd, 2018

Possible Futures

Arrowhead Pharmaceuticals Presents Late-Breaking Preliminary Clinical Data on ARO-HBV at Liver Meeting® 2018 November 9th, 2018

Unlocking the Secrets of Metal-Insulator Transitions: X-ray photon correlation spectroscopy at NSLS-II's CSX beamline used to understand electrical conductivity transitions in magnetite November 8th, 2018

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

The National Graphene Association Is Excited To Announce A New Affiliate Partnership With Graphene Engineering Innovation Centre (GEIC) November 7th, 2018

Nanomedicine

Arrowhead Pharmaceuticals Presents Late-Breaking Clinical Data on ARO-AAT at Liver Meeting® 2018 November 9th, 2018

Arrowhead Pharmaceuticals Presents Late-Breaking Preliminary Clinical Data on ARO-HBV at Liver Meeting® 2018 November 9th, 2018

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

A record-long polymer DNA negative November 6th, 2018

Discoveries

Unlocking the Secrets of Metal-Insulator Transitions: X-ray photon correlation spectroscopy at NSLS-II's CSX beamline used to understand electrical conductivity transitions in magnetite November 8th, 2018

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

A record-long polymer DNA negative November 6th, 2018

Nanotech Artisans Sculpt with DNA November 5th, 2018

Announcements

Arrowhead Pharmaceuticals Presents Late-Breaking Clinical Data on ARO-AAT at Liver Meeting® 2018 November 9th, 2018

Arrowhead Pharmaceuticals Presents Late-Breaking Preliminary Clinical Data on ARO-HBV at Liver Meeting® 2018 November 9th, 2018

Unlocking the Secrets of Metal-Insulator Transitions: X-ray photon correlation spectroscopy at NSLS-II's CSX beamline used to understand electrical conductivity transitions in magnetite November 8th, 2018

IEDM - CEA-Leti Will Present 11 Papers and Host Workshop on Disruptive Technologies for Data Management November 7th, 2018

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

Unlocking the Secrets of Metal-Insulator Transitions: X-ray photon correlation spectroscopy at NSLS-II's CSX beamline used to understand electrical conductivity transitions in magnetite November 8th, 2018

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

IEDM - CEA-Leti Will Present 11 Papers and Host Workshop on Disruptive Technologies for Data Management November 7th, 2018

A record-long polymer DNA negative November 6th, 2018

Military

Unlocking the Secrets of Metal-Insulator Transitions: X-ray photon correlation spectroscopy at NSLS-II's CSX beamline used to understand electrical conductivity transitions in magnetite November 8th, 2018

Physicists name and codify new field in nanotechnology: ‘electron quantum metamaterials:’ UC Riverside’s Nathaniel Gabor and colleague formulate a vision for the field in a perspective article November 5th, 2018

A bullet-proof heating pad November 2nd, 2018

Tiny light detectors work like gecko ears October 30th, 2018

Grants/Sponsored Research/Awards/Scholarships/Gifts/Contests/Honors/Records

Physicists name and codify new field in nanotechnology: ‘electron quantum metamaterials:’ UC Riverside’s Nathaniel Gabor and colleague formulate a vision for the field in a perspective article November 5th, 2018

Eco-friendly waterproof polymer films synthesized using novel method October 31st, 2018

Rice U. scientists form flat tellurium: Two-dimensional element shows promise for solar cells and other optoelectronics October 26th, 2018

Iran World’s Second Largest Producer of Nano-Catalysts October 17th, 2018

Nanobiotechnology

Arrowhead Pharmaceuticals Presents Late-Breaking Clinical Data on ARO-AAT at Liver Meeting® 2018 November 9th, 2018

Arrowhead Pharmaceuticals Presents Late-Breaking Preliminary Clinical Data on ARO-HBV at Liver Meeting® 2018 November 9th, 2018

WSU researchers develop new technique to understand biology at the nanoscale November 7th, 2018

A record-long polymer DNA negative November 6th, 2018

Research partnerships

The National Graphene Association Is Excited To Announce A New Affiliate Partnership With Graphene Engineering Innovation Centre (GEIC) November 7th, 2018

2-D magnetism: Atom-thick platforms for energy, information and computing research: Scientists say the tiny 'spins' of electrons show potential to one day support next-generation innovations in many fields October 31st, 2018

Tiny light detectors work like gecko ears October 30th, 2018

Leti Middleware Will Be Core of Fog Platform for Decentralized Cloud-to-Edge AI: DECENTER Project to Integrate IoT, AI, the Cloud, Edge, Fog Computing and Smart Contracts Tied Together with Secure Blockchain in ‘New Ecosystem’ for On-Demand Edge Computing October 26th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project