Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Magnetized viruses attack harmful bacteria: Rice, China team uses phage-enhanced nanoparticles to kill bacteria that foul water treatment systems

Clusters of nanoparticles with phage viruses attached find and kill Escherichia coli bacteria in a lab test at Rice University. Researchers at Rice and the University of Science and Technology of China have developed a combination of antibacterial phages and magnetic nanoparticle clusters that infect and destroy bacteria that are usually protected by biofilms in water treatment systems. (Credit: Alvarez Group/Rice University)
Clusters of nanoparticles with phage viruses attached find and kill Escherichia coli bacteria in a lab test at Rice University. Researchers at Rice and the University of Science and Technology of China have developed a combination of antibacterial phages and magnetic nanoparticle clusters that infect and destroy bacteria that are usually protected by biofilms in water treatment systems. (Credit: Alvarez Group/Rice University)

Abstract:
Magnetic nanoparticle clusters have the power to punch through biofilms to reach bacteria that can foul water treatment systems, according to scientists at Rice University and the University of Science and Technology of China.

Magnetized viruses attack harmful bacteria: Rice, China team uses phage-enhanced nanoparticles to kill bacteria that foul water treatment systems

Houston, TX | Posted on August 2nd, 2017

The nanoclusters developed through Rice's Nanotechnology-Enabled Water Treatment (NEWT) Engineering Research Center carry bacteriophages – viruses that infect and propagate in bacteria – and deliver them to targets that generally resist chemical disinfection.

Without the pull of a magnetic host, these "phages" disperse in solution, largely fail to penetrate biofilms and allow bacteria to grow in solution and even corrode metal, a costly problem for water distribution systems.

The Rice lab of environmental engineer Pedro Alvarez and colleagues in China developed and tested clusters that immobilize the phages. A weak magnetic field draws them into biofilms to their targets.

The research is detailed in the Royal Society of Chemistry's Environmental Science: Nano.

"This novel approach, which arises from the convergence of nanotechnology and virology, has a great potential to treat difficult-to-eradicate biofilms in an effective manner that does not generate harmful disinfection byproducts," Alvarez said.

Biofilms can be beneficial in some wastewater treatment or industrial fermentation reactors owing to their enhanced reaction rates and resistance to exogenous stresses, said Rice graduate student and co-lead author Pingfeng Yu. "However, biofilms can be very harmful in water distribution and storage systems since they can shelter pathogenic microorganisms that pose significant public health concerns and may also contribute to corrosion and associated economic losses," he said.

The lab used phages that are polyvalent – able to attack more than one type of bacteria – to target lab-grown films that contained strains of Escherichia coli associated with infectious diseases and Pseudomonas aeruginosa, which is prone to antibiotic resistance.

The phages were combined with nanoclusters of carbon, sulfur and iron oxide that were further modified with amino groups. The amino coating prompted the phages to bond with the clusters head-first, which left their infectious tails exposed and able to infect bacteria.

The researchers used a relatively weak magnetic field to push the nanoclusters into the film and disrupt it. Images showed they effectively killed E. coli and P. aeruginosa over around 90 percent of the film in a test 96-well plate versus less than 40 percent in a plate with phages alone.

The researchers noted bacteria may still develop resistance to phages, but the ability to quickly disrupt biofilms would make that more difficult. Alvarez said the lab is working on phage "cocktails" that would combine multiple types of phages and/or antibiotics with the particles to inhibit resistance.

Graduate student Ling-Li Li of the University of Science and Technology of China, Hefei, is co-lead author of the paper. Co-authors are graduate student Sheng-Song Yu and Han-Qing Yu, a professor at the University of Science and Technology of China, and graduate student Xifan Wang and temporary research scientist Jacques Mathieu of Rice.

The National Science Foundation and its Rice-based NEWT Engineering Research Center supported the research.

####

About Rice University
Located on a 300-acre forested campus in Houston, Rice University is consistently ranked among the nation’s top 20 universities by U.S. News & World Report. Rice has highly respected schools of Architecture, Business, Continuing Studies, Engineering, Humanities, Music, Natural Sciences and Social Sciences and is home to the Baker Institute for Public Policy. With 3,879 undergraduates and 2,861 graduate students, Rice’s undergraduate student-to-faculty ratio is 6-to-1. Its residential college system builds close-knit communities and lifelong friendships, just one reason why Rice is ranked No. 1 for happiest students and for lots of race/class interaction by the Princeton Review. Rice is also rated as a best value among private universities by Kiplinger’s Personal Finance. To read “What they’re saying about Rice,” go to http://tinyurl.com/RiceUniversityoverview .

Follow Rice News and Media Relations via Twitter @RiceUNews

For more information, please click here

Contacts:
David Ruth
713-348-6327


Mike Williams
713-348-6728

Copyright © Rice University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Read the abstract at:

Pedro Alvarez bio:

Nanotechnology-Enabled Water Treatment (NEWT):

George R. Brown School of Engineering

Related News Press

News and information

A New Way to Measure Nearly Nothing: NIST prototype design uses ultracold trapped atoms to measure pressure October 22nd, 2018

Shape-shifting sensors could catch early signs of cancer October 19th, 2018

Study provides insight into how nanoparticles interact with biological systems: Findings can help scientists engineer nanoparticles that are ‘benign by design’ October 18th, 2018

Fat-Repellent Nanolayers Can Make Oven Cleaning Easier October 17th, 2018

Magnetism

Graphene controls surface magnetism at room temperature October 8th, 2018

The nanoscience of ferroelectric and ferromagnetic domains converges on Barcelona September 27th, 2018

New devices based on rust could reduce excess heat in computers: Physicists explore long-distance information transmission in antiferromagnetic iron oxide September 14th, 2018

How a tetrahedral substance can be more symmetrical than a spherical atom: A new type of symmetry September 14th, 2018

Govt.-Legislation/Regulation/Funding/Policy

A New Way to Measure Nearly Nothing: NIST prototype design uses ultracold trapped atoms to measure pressure October 22nd, 2018

Shape-shifting sensors could catch early signs of cancer October 19th, 2018

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1 Study of ARO-ANG3 October 15th, 2018

High-performance self-assembled catalyst for SOFC October 12th, 2018

Possible Futures

A New Way to Measure Nearly Nothing: NIST prototype design uses ultracold trapped atoms to measure pressure October 22nd, 2018

Shape-shifting sensors could catch early signs of cancer October 19th, 2018

Study provides insight into how nanoparticles interact with biological systems: Findings can help scientists engineer nanoparticles that are ‘benign by design’ October 18th, 2018

Iran Unveils Its First Homegrown 3D Nano Printer October 17th, 2018

Discoveries

A New Way to Measure Nearly Nothing: NIST prototype design uses ultracold trapped atoms to measure pressure October 22nd, 2018

Shape-shifting sensors could catch early signs of cancer October 19th, 2018

Study provides insight into how nanoparticles interact with biological systems: Findings can help scientists engineer nanoparticles that are ‘benign by design’ October 18th, 2018

High-performance self-assembled catalyst for SOFC October 12th, 2018

Materials/Metamaterials

Aculon, Inc. Enters into Strategic Partnership Agreement with Henkel Corporation to Supply Key Mobile Device Manufacturers with NanoProof® PCB Waterproof Technology October 17th, 2018

Big award enables study of small surfaces: Rice U.'s Matt Jones wins Packard Fellowship to view nanoscale chemical reactions October 15th, 2018

Graphene controls surface magnetism at room temperature October 8th, 2018

Unmasking corrosion to design better protective thin films for metals: Researchers from three universities team up to analyze oxide films at atomic level October 3rd, 2018

Announcements

A New Way to Measure Nearly Nothing: NIST prototype design uses ultracold trapped atoms to measure pressure October 22nd, 2018

Shape-shifting sensors could catch early signs of cancer October 19th, 2018

Study provides insight into how nanoparticles interact with biological systems: Findings can help scientists engineer nanoparticles that are ‘benign by design’ October 18th, 2018

Arrowhead Pharmaceuticals Hosts R&D Day on Pipeline of RNAi Therapeutics October 17th, 2018

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers

A New Way to Measure Nearly Nothing: NIST prototype design uses ultracold trapped atoms to measure pressure October 22nd, 2018

Study provides insight into how nanoparticles interact with biological systems: Findings can help scientists engineer nanoparticles that are ‘benign by design’ October 18th, 2018

Big award enables study of small surfaces: Rice U.'s Matt Jones wins Packard Fellowship to view nanoscale chemical reactions October 15th, 2018

High-performance self-assembled catalyst for SOFC October 12th, 2018

Environment

Study provides insight into how nanoparticles interact with biological systems: Findings can help scientists engineer nanoparticles that are ‘benign by design’ October 18th, 2018

Silver nanoparticles are toxic for aquatic organisms: A research team at the UPV/EHU-University of the Basque Country has analysed how zebrafish are affected in the long term by exposure to silver particles September 19th, 2018

Carbon nanodots do an ultrafine job with in vitro lung tissue: New experiments highlight the role of charge and size when it comes to carbon nanodots that mimic the effect of nanoscale pollution particles on the human lung. September 12th, 2018

A human enzyme can biodegrade graphene August 28th, 2018

Water

Aculon, Inc. Enters into Strategic Partnership Agreement with Henkel Corporation to Supply Key Mobile Device Manufacturers with NanoProof® PCB Waterproof Technology October 17th, 2018

Silver nanoparticles are toxic for aquatic organisms: A research team at the UPV/EHU-University of the Basque Country has analysed how zebrafish are affected in the long term by exposure to silver particles September 19th, 2018

Halas wins American Chemical Society Award in Colloid Chemistry: Rice University nanophotonics pioneer honored for colloid research September 18th, 2018

S, N co-doped carbon nanotube-encapsulated CoS2@Co: Efficient and stable catalysts for water splitting September 10th, 2018

Industrial

A New Way to Measure Nearly Nothing: NIST prototype design uses ultracold trapped atoms to measure pressure October 22nd, 2018

Graphene nanotubes outperform ammonium salts and carbon black in PU applications September 11th, 2018

Carbon in color: First-ever colored thin films of nanotubes created: A method developed at Aalto University, Finland, can produce large quantities of pristine single-walled carbon nanotubes in select shades of the rainbow; the secret is a fine-tuned fabrication process -- and a s August 29th, 2018

Connecting the (Nano) Dots: NIST Says Big-Picture Thinking Can Advance Nanoparticle Manufacturing August 22nd, 2018

Research partnerships

Tracking a Killer: UCSB, UCSD and SBP researchers trace the complex and variable pathways to the deadly condition known as sepsis October 12th, 2018

Columbia Engineers Build Smallest Integrated Kerr Frequency Comb Generator October 9th, 2018

Leti Announces EU Project to Develop Powerful, Inexpensive Sensors with Photonic Integrated Circuits: REDFINCH Members Initially Targeting Applications for Gas Detection and Analysis For Refineries & Petrochemical Industry and Protein Analysis for Dairy Industry September 19th, 2018

Researchers develop microbubble scrubber to destroy dangerous biofilms September 19th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project