Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International



Home > Press > Nanospheres shield chemo drugs, safely release high doses in response to tumor secretions

Abstract:
Scientists have designed nanoparticles that release drugs in the presence of a class of proteins that enable cancers to metastasize. That is, they have engineered a drug delivery system so that the very enzymes that make cancers dangerous could instead guide their destruction.

Nanospheres shield chemo drugs, safely release high doses in response to tumor secretions

San Diego, CA | Posted on July 14th, 2015

"We can start with a small molecule and build that into a nanoscale carrier that can seek out a tumor and deliver a payload of drug," said Cassandra Callmann, a graduate student in chemistry and biochemistry at the University of California, San Diego, and first author of the report published in the journal Advanced Materials July 14.

The system takes advantage of a class enzymes called matrix metalloproteinases that many cancers make in abundance. MMPs chew through membranes, allowing cancer cells to escape to colonize other regions of the body, often with deadly consequences.

Callmann created tiny spheres packed with the anti-cancer drug paclitaxel (also known by the trade names Taxol and Onxal) and coated with a peptide shell. MMPs tear up that shell, releasing the drug. The shell fragments form a ragged mesh that holds the drug molecules near the tumor.

The work, led by Nathan Gianneschi a professor of chemistry and biochemisty at UC San Diego, builds on his group's earlier sucess using a similar strategy to mark tumors for both diagnosis and precise surgical removal.

To package the drug into the spheres, Callmann had to add chemical handles. As it turns out, a group of atoms essential to the drug molecule's effectiveness, and also toxicity, made for a good attachment point. That means the drug was inactivated as it flowed through the circulatory system until it reached the tumor.

The protection allowed the researchers to safely give a dose 16 times higher than they could with the formulation now used in cancer clinics, in a test in mice with grafted in fibrosarcoma tumors.

In additional preliminary tests, Callmann and colleagues were able to halt the growth of the tumors for a least two weeks, using a single lower dose of the drug. In mice treated with the nanoparticles coated with peptides that are impervious to MMPs or given saline, the tumors grew to lethal sizes within that time.

Gianneschi says they will broaden their approach to create delivery systems for other diagnostic and therapeutic molecules. "This kind of platform is not specific to paclitaxel. We'll test this in other models - with other classes of drug and in mice with a cancer that mimics metastatic breast cancer, for example."

They'll also continue to modify the shell, to provide even greater protection and avoid uptake by organs such as liver, spleen and kidneys, he said. "We want to open up this therapeutic window."

###

Additional authors include Matthew Thompson in Gianneschi's chemistry research group and Christopher Barback, David Hall and Robert Mattrey in UC San Diego's Moores Cancer Center. All animal procedures were approved by UC San Diego's institution animal care and use committee. Callmann holds a fellowship through the Cancer Researchers in Nanotechnology Program at UC San Diego. The National Institute of Biomedical Imaging and Bioengineering provided financial support.

This novel approach to using enzyme-directed assembly of particle theranostics (EDAPT) is patent pending. Skip Cynar, , in UC San Diego's technology transfer office can provide information about commercial development.

####

For more information, please click here

Contacts:
Susan Brown

858-246-0161

Copyright © University of California - San Diego

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Cancer

How different cancer cells respond to drug-delivering nanoparticles: The findings of a large-scale screen could help researchers design nanoparticles that target specific types of cancer July 22nd, 2022

News and information

Biology’s hardest working pigments and ‘MOFs’ might just save the climate: A range of processes that currently depend on fossil fuels but are really hard to electrify will depend on the development of genuinely clean fuels, and for that to happen, much more efficient catalysts wi July 22nd, 2022

Generating power where seawater and river water meet July 22nd, 2022

First electric nanomotor made from DNA material: Synthetic rotary motors at the nanoscale perform mechanical work July 22nd, 2022

At the water’s edge: Self-assembling 2D materials at a liquid–liquid interface: Scientists find a simple way to produce heterolayer coordination nanosheets, expanding the diversity of 2D materials July 22nd, 2022

Govt.-Legislation/Regulation/Funding/Policy

UNC Charlotte-led team invents new anticoagulant platform, offering hope for advances for heart surgery, dialysis, other procedures July 15th, 2022

Strain-sensing smart skin ready to deploy: Nanotube-embedded coating detects threats from wear and tear in large structures July 15th, 2022

Rensselaer researchers learn to control electron spin at room temperature to make devices more efficient and faster: Electron spin, rather than charge, holds the key July 15th, 2022

Crystal phase engineering offers glimpse of future potential, researchers say July 15th, 2022

Nanomedicine

How different cancer cells respond to drug-delivering nanoparticles: The findings of a large-scale screen could help researchers design nanoparticles that target specific types of cancer July 22nd, 2022

Biology’s hardest working pigments and ‘MOFs’ might just save the climate: A range of processes that currently depend on fossil fuels but are really hard to electrify will depend on the development of genuinely clean fuels, and for that to happen, much more efficient catalysts wi July 22nd, 2022

Study reveals new mode of triggering immune responses July 15th, 2022

UNC Charlotte-led team invents new anticoagulant platform, offering hope for advances for heart surgery, dialysis, other procedures July 15th, 2022

Discoveries

HKU physicists found signatures of highly entangled quantum matter July 22nd, 2022

How different cancer cells respond to drug-delivering nanoparticles: The findings of a large-scale screen could help researchers design nanoparticles that target specific types of cancer July 22nd, 2022

The best semiconductor of them all? Researchers have found a material that can perform much better than silicon. The next step is finding practical and economic ways to make it July 22nd, 2022

Buckyballs on gold are less exotic than graphene July 22nd, 2022

Announcements

Quantum computer works with more than zero and one: Quantum digits unlock more computational power with fewer quantum particles July 22nd, 2022

Biology’s hardest working pigments and ‘MOFs’ might just save the climate: A range of processes that currently depend on fossil fuels but are really hard to electrify will depend on the development of genuinely clean fuels, and for that to happen, much more efficient catalysts wi July 22nd, 2022

Generating power where seawater and river water meet July 22nd, 2022

First electric nanomotor made from DNA material: Synthetic rotary motors at the nanoscale perform mechanical work July 22nd, 2022

Interviews/Book Reviews/Essays/Reports/Podcasts/Journals/White papers/Posters

Buckyballs on gold are less exotic than graphene July 22nd, 2022

Quantum computer works with more than zero and one: Quantum digits unlock more computational power with fewer quantum particles July 22nd, 2022

Biology’s hardest working pigments and ‘MOFs’ might just save the climate: A range of processes that currently depend on fossil fuels but are really hard to electrify will depend on the development of genuinely clean fuels, and for that to happen, much more efficient catalysts wi July 22nd, 2022

Generating power where seawater and river water meet July 22nd, 2022

Patents/IP/Tech Transfer/Licensing

Study finds nanomedicine targeting lymph nodes key to triple negative breast cancer treatment: In mice, nanomedicine can remodel the immune microenvironment in lymph node and tumor tissue for long-term remission and lung tumor elimination in this form of metastasized breast cance May 13th, 2022

Metasurfaces control polarized light at will: New research unlocks the hidden potential of metasurfaces August 13th, 2021

Arrowhead Pharmaceuticals Announces Closing of Agreement with Takeda November 27th, 2020

HORIBA Medical and CEA-Leti Strengthen Their Partnership to Develop Tomorrow’s Diagnostics at the Point of Care July 21st, 2020

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project